Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Bioengineering--Materials."”.
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Assessment of the biocompatibility, stability, and suitability of novel thermoresponsive films for the rapid generation of cellular constructs
… polymers (SRP) are of great interest in the bioengineering community due to their use in applications such as drug delivery and tissue engineering. One example of an SRP is poly(N-isopropyl acrylamide) or pNIPAM. This SRP has the capability of changing its conformation with a slight …
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
<p>Lung cancers are leading cause of cancer death for both men and women in the world. Lungs are also one of the primary organs to which almost all cancer can spread. Chemothepray plays a crucial role in the fight against both primary lung cancers and lung metastases. Doxorubicin (DOX) is a potent …
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Development And Application Of Biomimetic Electrospun Nanofibers In Total Joint Replacement
… PCL/PVA electrospun nanofibers as promising biomaterials that can be applied on joint replacement prosthesis to improve osseointegration and prevent osteomyelitis.</p>
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Nanoscale Enhancement of Photosensitized Radionuclide Stimulated Therapy
… with a reduction in metastasis. However, these materials had previously been limited by their dependence upon external light sources, allowing treatment of only laser-accessible malignancy. With the recent development of photosensitized radiation stimulated therapy (PRaST) this depth dependence …
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Modeling the Effects of Mechanical Loading on Hypertrophic Cardiomyopathy Pathogenesis in Human Induced Pluripotent Stem Cell derived Micro Heart Muscle
<p>Sudden cardiac death in the young is devastating. Advances in genetics have associated mutations in the contractile sarcomere apparatus of cardiomyocytes with hypertrophic cardiomyopathy, the most frequent cause of sudden cardiac death in the young. Currently, it is challenging to predict …
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Supercritical carbon dioxide-processed resorbable polymer nanocomposites for bone graft substitute applications
… situations necessitate the use of bone graft materials to enhance bone formation. While autologous and allogenic materials are considered the gold standards in the setting of fracture healing and spine fusion, their disadvantages, which include donor site morbidity and finite supply have …
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Shape dependent iron oxide nanoparticles for simultaneous imaging and therapy
The primary focus of this dissertation is to explore the use of shape dependent iron oxide nanoparticles as magnetic resonance imaging contrast agents. In addition to biocompatibility, nanoparticles provide a foundation for implementing imaging guided drug delivery systems. We begin with the …
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Development Of Scaffold Architectures And Heterotypic Cell Systems For Hepatocyte Transplantation
<p>In vitro assembly of functional liver tissue is needed to enable the transplantation of tissue-engineered livers. In addition, there is an increasing demand for in vitro models that replicate complex events occurring in the liver. However, tissue engineering of sizable implantable liver systems …
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Mechanical Property and Phenotype Characterization of an in vitro Model for Afterload-triggered Cardiac Hypertrophy
<p>Hypertrophic Cardiomyopathy (HCM) is an inherited cardiomyopathy disease that affects approximately 1 in 500 to 1 in 200 people. Although abundant evidence has shown that HCM is related to sarcomere genetic mutations, recent research has also revealed that conditions that increase cardiac …
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Surface modification of traditional and bioresorbable metallic implant materials for improved biocompatibility
… metals have been preferred. These permanent materials can cause negative systemic and local tissue effects in the long-term. Permanent stenting can lead to late-stent thrombosis and in-stent restenosis. Metallic pins and screws for fracture fixation can corrode and fail, cause loss of bone …