Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 864 for “"Bioengineering"”.
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Bioengineering-enhanced neurosurgical solutions
… upon the window of opportunity to exploit bioengineering techniques in three subspecialties of this vast discipline: neuro-oncology, radiosurgery and neuro-traumatology. After a thorough identification of some unresolved clinical problems and the limits of current management strategies in …
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Bioengineering of Heterogenous Glioblastoma Multiforme Microenvironment
Glioblastoma (GBM) is the most aggressive brain tumor that originates from glioblastoma stem cells (GSCs). In the brain, GSCs are supported by a tumor microenvironment (TME) wherein the perivascular niche and hypoxic region are present. The glioblastoma microenvironment (GBME) exhibits high …
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Bioengineering Analysis of Traumatic Brain Injury
Traumatic brain injury (TBI) is a serious health concern affecting over a million people in the UK. Brain shift and herniation, which are closely related to severe disability or death, are important signs of abnormally elevated intracranial pressure (ICP) or space-occupying intracranial mass after …
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A bioengineering roadmap for negative emissions technologies
… global temperature rise and ocean acidification. Bioengineering capabilities have not been sufficiently assessed or utilized for the development of negative emissions technologies. Bioengineering holds the potential to improve the efficiency of some existing technologies and to create new methods …
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BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE
The gastrointestinal (GI) tract is a hollow muscular tubular organ that extends from the mouth down to the rectum. Different high pressure zones exist along the tract and are referred to as sphincters. Sphincters maintain a closure tone and relax upon receiving the appropriate signal to allow …
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Bioengineering strategies to improve functional qualities of nisin
… compared to that of wild-type nisin A. Peptide bioengineering approaches were also implemented to obtain additional novel derivatives of nisin. The generation of “S5X” and “S33X” banks (representing a change of natural serines at positions 5 and 33 to all possible alternative residues) by a …
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Supporting mental health and wellness of bioengineering students
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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Bioengineering of nisin to enhance functionality against dairy pathogens
The bacteriocin class of antimicrobial peptides have emerged as a viable alternative to at least partially fill the void created by the end of the golden age of antibiotic discovery. Along with this potential use in a clinical setting, bacteriocins also play an important role as bio-preservatives …
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The structure, biophysics and bioengineering of secretory immunoglobin A
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Model-based scientific discovery--a study in space bioengineering
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, 1992
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Bioengineering functional polymer systems for glycan-based targeting and drug release
Bioengineering drug delivery facilitates re-potentiation of existing drugs and drug candidates, bypassing hurdles in novel drug development and accelerating the advance of medicine. Drug delivery strategies aim to enhance therapeutic effect by enhancing delivery to the target cells or tissues, …
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Frankenfoods: Are We Bioengineering Our Children and What Can Curriculum Do?
<p>In this dissertation I explore the effect of biotechnology and food production on children’s physical and mental health. What we eat affects our well-being and unknowingly, we have little control of what exactly we are consuming. Children have even less control and feel the effects of additives …
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Application of a substrate-tolerant lanthipeptide synthetase in bioengineering peptide natural products
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Exploration of helicase mechanisms at single molecule level: answering decades old questions and bioengineering super proteins
In the last 15 years, single molecule techniques have allowed us to observe the transient, heterogeneous, and multi‐step behavior of biomolecules often averaged out and lost in ensemble assays. Helicases form a ubiquitous class of enzymes that function in many aspects of nucleic acid metabolism …
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Exploration of helicase mechanisms at single molecule level: answering decades old questions and bioengineering super proteins
In the last 15 years, single molecule techniques have allowed us to observe the transient, heterogeneous, and multi‐step behavior of biomolecules often averaged out and lost in ensemble assays. Helicases form a ubiquitous class of enzymes that function in many aspects of nucleic acid metabolism …
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Harnessing Systems Bioengineering Approaches to Study Microbe-Microbe and Host-Microbe Interactions in Health and Disease
… lies in developing two novel systems bioengineering approaches, a synthetic Escherichia coli killer-prey microecology, and a combined infection-inflammation NET-array system, to investigate the role of the mechanochemical complexity of the microenvironment in driving the …
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Bioengineering the Expression of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, and C-Reactive Protein in Yeast
<p>The yeasts Pichia pastoris and Kluyveromyces lactis were used to express several recombinant human proteins for further biochemical characterization. Two substitution variants of recombinant human enteropeptidase light chain (rhEPL) were engineered to modify the extended substrate specificity of …
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Bioengineering Microporous Annealed Particle Scaffolds to Recruit Neural Progenitor Stem Cells and Promote Angiogenesis in the Stroke Core
<p>There remains a significant gap in the need for regenerative therapies for stroke compared to what is currently available. An ideal therapy would be one that stimulates the formation of new tissue with the ability to regain any function previously lost due to stroke. Therefore, methods …
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