Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Biodefense"”.
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New forces yet undetermined : the challenge of biodefense
This dissertation finds that the full implementation of the traditional security approaches of prevention, deterrence and defense would not be effective at protecting the United States from a catastrophic biological attack. The traditional approaches would not merely fail but would be …
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Maximum containment : the most controversial labs in the world
… weapons, and to contribute to the nation's biodefense. These labs were not the first dramatic reaction to the threat of biowarfare and are in fact, one product of a long history of the country's contentious relationship with biological weapons. Of the two labs created, Boston University …
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A Recombinant Vesicular Stomatitis Virus Expressing the Junin Virus Glycoprotein for Arenavirus Countermeasure Development
Arenaviruses are pathogens of biodefense importance due to their potential for aerosol transmission and mortality rates reaching 30%. Here, we evaluated the use of a recombinant vesicular stomatitis virus expressing the Junin virus glycoprotein (rVSVΔG-JUNVGP) for the development of countermeasures …
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Deadly Science: Biological Weapons and the Threat to America
… This thesis will also examine America’s current biodefense strategy and preparedness and uncover vulnerabilities that might exist, making recommendations to what needs to be done to insure that America is prepared to deal with and defend against any possible biological attack scenario. Lastly, …
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Development of a High Sensitivity, Multiplex Vertical Flow Immunoassay System for the Detection of Biothreat Agents
Effective biodefense requires diagnostic technologies capable of rapidly screening potentially contaminant materials and individuals to safeguard public health. The historical reliance on centralized laboratory networks, with their delayed turnaround times, has motivated a shift toward developing …
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A Structural Basis for Host Cytoskeletal Disruption and Virulence by Yersinia Protein Kinase A
… pathogens that are currently an important biodefense and antibiotic resistance concern. Although several antibiotic therapies exist, the emergence of strains that have garnered multiple drug resistances in combination with the weaponization of Yersinia, make understanding the biology of …
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Identification of protective rickettsial antigens for vaccine development
… there is a need to develop countermeasures for biodefense, there are no commercially available vaccines. Resistance to rickettsial infections and cross-protective immunity between typhus and spotted fever group rickettsiae are attributed to the induction of antigen-specific T cells, particularly …
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The Electrochemistry of Ferrocenyl-thiolate Self-Assembled Monolayers for use in a Toll-like Receptor 4-based sensor
… time on-site analysis, which is imperative for biodefense applications. Unlike radiological and chemical warfare agents, sophisticated detection systems have not yet been designed for immediate sensing of biological agents. Development of field-deployable biosensors is a response to fulfill this …
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Sensitivity control of optical fiber biosensors utilizing turnaround point long period gratings with self-assembled polymer coatings
… in basic research, environmental monitoring, biodefense, and medicine. This research aims to show that Ionic Self-Assembled Multilayers (ISAMs) adsorbed on Long Period Gratings (LPGs) can serve as a highly sensitive, robust, inexpensive optical-based biosensor platform. The ISAM technique is a …
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Molecular design of nanoparticle-based delivery vehicles for pneumonic plague
… order to improve vaccination, specifically for biodefense-related applications. Chapter 1 is an introduction into the threat of bioterrorism, polymer-based controlled delivery systems and challenges associated with vaccine design.</p> <p>Chapter 2 is a detailed literature review of topics …
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A Review of the Government Sponsored Offensive Biological Programs, Weaponized Biological Pathogens and their Countermeasures
Since the beginning of the 20th century humanity’s capacity for warfare and death has evolved at an ever increasing rate. The horse was quickly replaced by the automobile and the rifle by the machine gun. The use of biological weapons (bioweapons) took the same leap forward from medics fighting …
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Bugs Dividing: The Impact of Synthetic Biology on the Proliferation of Biological Weapons
<p>One of the gravest threats facing the United States is the possible use of biological weapons by a near-peer state, rogue nation or terrorist organization. Currently there are an increasing number of pathogens suitable for biological weapons. This threat has increased due to the rapid advances …