Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Biochips"”.
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Herstellung von Biochips basierend auf selbstaggregierender Monolagen
… an die Entwicklung von sogenannten Biochips dar. Hierfür sind funktionalisierte Mikro- und Nanometer Strukturoberflächen mit sehr hoher Auflösung erforderlich. Ziel ist die Immobilisierung von Biomolekülen an wohl definierten funktionellen Positionen, um eine weitere detaillierte …
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Optimization, Testing and Design-for-Testability of Flow-Based Microfluidic Biochips
<p>Flow-based microfluidic biochips constitute an emerging technology for the automation of biochemical procedures. Recent advances in fabrication techniques have enabled the development of these devices. Increasing integration levels provide biochips with tremendous potential; a large number of …
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P450 biochips : development of a protein microarray platform for investigating cytochrome P450 clinical drug metabolism
This thesis describes the development of a novel cytochrome P450 array format, the P450 Biochip that allows quantitative and truly high-throughput measurement of cytochrome P450-mediated turnover reactions in sub-nanolitre volumes.
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Integration of tunneling magnetoresistive sensors for high resolutive magnetic particle detection
… diagnosis devices. Low cost production hand-held biochips are foreseen to be incorporated in the next generation of bionanodevices. Among them, tunneling magnetoresistive (TMR) biosensors are of great interest and their improvements constitute the subject of the present thesis.
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Large core polymer optical backplanes for fluorescence detection
… utilizes the same polymer materials used for biochips to create optical components. By combining elements such as waveguides and mirror couplers, arrays of small devices capable of out-of-plane detection are possible, decoupling the biochip design from the transducer design while still …
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Preparation and characterization of functionalized surfaces for desorption-ionization mass spectrometry
… MALDI mass spectrometry-compatible proteolytic biochips and their application in structural proteomics. These functionalized surfaces allow both the cleavage of the studied protein and the MALDI matrix crystallization followed by a mass spectrometric analysis to be performed within a single …
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Polyol- und Azlacton-Makromonomere für Netzwerksysteme, neue Werkstoffe und biomedizinische Anwendungen
… mit Azlactonen wurde zur Entwicklung eines Biochips zum Nachweis von hereditärer Hämochromatose genutzt.
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Micro and Nano patterns for Biosensing: from enzymatic assays to single cells interaction arrays
… for the creation of complex protein biochips on modified glass surfaces displaying spots of cell-specific ligands with lateral dimensions minor than one single cell. In a first application the epidermal growth factor (EFG) protein arrays were realized to display specific single cell …
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Controlling the assembly of proteins and cells on SiO₂ surfaces
A variety of devices -- biochips, implants, and membrane filters among them -- are challenged in their operation by having to contact biological solutions. An ever-present problem for such devices is "biofouling," resulting from the nonspecific adsorption of proteins, cells, and other agents onto …
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Katalytische molekular geprägte Polymere : Herstellung und Anwendung in einem Thermistor
… sowie in Biosensoren und Biochips zu ersetzen. Trotz einiger publizierter Sensorkonfigurationen steht der große Durchbruch noch aus. Ein Hindernis für Routineanwendungen ist die Signalgenerierung bei Bindung des Analyten an das Polymer. Eine Möglichkeit für die markerfreie …
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Mesoscale simulation of the photoresist process and hydrogel biosensor array platform indexed by shape
… fields in the 1980s led to the development of biochips in the 1990s. These devices enable rapid and simultaneous screening of a large number of biological analytes in a compact space, for a variety of applications. Cancer diagnosis through DNA typing, public water systems testing, and airline …
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Printed electronics : the next inkjet revolution
… displays and low cost circuits to generation of biochips and fast-prototyping of 3-D objects. These new applications present existing inkjet players with exciting opportunities to leverage their knowledge and assets to exploit these new markets. This thesis explores the opportunities for inkjet …
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Fluorescence Resonance Energy Transfer (FRET) systems for biomedical sensor applications
… FRET platform that is compatible with optical biochips. The donor-acceptor pair used was a Ruthenium-complex/Cy5 system where the donor-acceptor separation was controlled using highly reproducible polyelectrolyte spacer layers, which were deposited using a layer-by-layer technique. The FRET …
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Development of low-cost and easy-to-use tools for multiplex pathogen detection
Thesis (Ph. D.)--Michigan State University. Environmental Engineering, 2010
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Elektrochemische Detektion von RNA mittels Nukleinsäurehybridisierung
… Goldelektrode eines elektrochemisch-auslesbaren Biochips immobilisiert und bindet die bakterielle 16S rRNA. Zeitgleich bindet ein kovalentes Konjugat aus Esterase 2 und Detektions-Oligodesoxynukleotid an einem konservierten Bereich der 16S rRNA. Nach Optimierung dieses Nachweissystems wurde eine …
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Integration von Rezeptoren in inerte Matrices zur markierungsfreien und quantitativen Detektion biospezifischer Wechselwirkungen mit LSPR-aktiven Nanopartikeloberflächen
… in hoch parallelisierten und miniaturisierten Biochips (DNA-, Peptid- und Protein-Arrays), in denen eine Vielzahl an Bin¬dungsereignissen ortsaufgelöst und simultan (bei Einsatz einer CCD-Kamera) bestimmt werden können. Zur Demonstration einer solchen Applikation wurden photochemisch …
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Über das Benetzungsverhalten polymermodifizierter Grenzflächen
… Möglichkeiten für das (mehrfache) Bedrucken von Biochips bietet und so gängige Probleme während des Herstellungsprozesses vermieden werden können. <br>Der dritte Teil der Arbeit umfasste Versuche zur Herstellung einer biomimetischen Frauenmanteloberfläche. Mittels eines doppelten Abformansatzes …
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BIOMOLECULAR PRINTING FOR ARTIFICIAL LIFE-INSPIRED COMPARTMENTS AND SINGLE-CELL ARRAYS
… micropatterns for applications as biosensors and biochips. A novel approach based on inkjet printing has been exploited to pattern cell-adhesive biomaterials for single-cell harvesting and manipulation. The chip was realized by a novel green chemistry approach that combines polymeric layer …