Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 61 for “"Biochemistry::Molecular biology"”.
-
A computational and experimental study of HER2-signaling effects on cellular migration and proliferation
… years of research in the related fields of biochemistry, molecular biology, and genetics have demonstrated that, in most cases, the cellular decision-making process cannot be described or predicted by regulation of only one gene or one protein alone. Instead, it has become clear that …
-
Informing Therapeutic Approaches For Infectious Disease And Heart Disease, Focusing On Cell-Free Synthesis Of Bacteriophages And Calcium Transport By Serca
… 1-3), followed by research in the Department of Biochemistry, Molecular Biology and Biophysics, advised by Dr. David Thomas (Ch. 4). In Chapter 1, I cover the functional scope and optimizations of the cell-free transcription and translation (TX-TL) platform developed in the Noireaux lab, as …
-
Advancing detection, genomics, and secretome analysis of oomycete pathogens Phytophthora capsici and Phytopythium vexans to explore mechanisms of pathogenesis and biocontrol solutions
… as significant threats. Understanding the molecular mechanisms underlying their pathogenicity is critical for developing informed, site-specific disease management strategies. This thesis integrates comparative genomics, effector biology, and molecular diagnostics to enhance our …
-
Binding Determinants of HIV-1 REV RNA to the Pokeweed Antiviral Protein
The pokeweed antiviral protein (PAP) is an N-glycosidase that removes an adenine residue from the sarcin/ricin loop (SRL) of rRNA through a process called depurination. PAP has also been shown to depurinate the ORF of Rev RNA of HIV-1 in vivo without causing toxicity. The sequence and structure of …
-
Green tea antioxidants inhibition of oxidation and mutation
Green tea is a complex mixture containing several major potent antioxidants e.g., flavins and/or polyphenols. These antioxidants in green tea may react directly or indirectly with strong oxidizers e.g. peroxynitrite or its constituents (superoxide or nitric oxide). Green tea antioxidants can …
-
A Structural Basis for Neuropathic Pain Syndromes Associated with Mutations in Nav1.7
Voltage-gated sodium channels (Navs) are responsible for the upstroke of action potentials in electrically excitable cells. Transmission of nociceptive information from the body periphery to the central nervous system is mediated by specific isoforms of Navs present in dorsal root ganglion (DRG) …
-
Characterization of cpeY and cpeZ mutants in Fremyella diplosiphon strain UTEX 481
<p>Phycoerythrin (PE) present on the outer phycobilisome (PBS) rods in <em>Fremyella diplosiphon</em> contains covalently attached phycoerythrobilin (PEB) chromophores for efficient photosynthetic light capture. Chromophore ligation on phycobiliprotein subunits occurs through bilin lyase catalyzed …
-
Characterization of Endothelial Nitric Oxide Synthase Serine-600 Phosphorylation
<p>Endothelial nitric oxide synthase (eNOS) is part of a family of three nitric oxide synthase (NOS) enzymes that catalyze the production of nitric oxide (NO). NO is a gaseous, free-radical signaling molecule that has a variety of cellular and physiological functions that range from maintaining …
-
Virus-Host Interactions during Epstein-Barr virus Latent Infection of B cells
<p>Epstein-Barr virus latently infects over 90% of the adult global population. While it generally results in a completely asymptomatic lifelong infection, EBV is associated with and the causative agent of several human malignancies, particularly in cases of immune suppression. There is extensive …
-
Effect of Quantum Dots, Novel Biological Imaging Agents, in Liver Cells in Vitro
The use of Quantum dots (QDs) coated with polymer and functionalized with carboxylic acid groups in medical applications are explored. Their water solubility and exceptional stability in aqueous environments make them potentially useful for such applications as imaging and ligand attachments. …
-
Geometric Build-up Solutions for Protein Determination via Distance Geometry
… methods. Another problem that often arises in molecular modeling is referred to as the Molecular Distance Geometry Problem (MDGP). This problem seeks to find coordinates for the atoms of a protein or molecule when given only a set of pair-wise distances between atoms. To introduce the …
-
Production of Copper-Complexing Ligands in Response to Elevated Concentrations of Copper in Marine <i>Synechococcus</i> spp.
… copper binding component (CBC) of low molecular weight (Synechococcus PCC 73109 produced an intracellular CBC after exposure to [special characters omitted]8 μM CuSO<sub>4</sub> for 2 hr. The intracellular CBC was shown not to be MT, phytochelatin or a siderophore. It is not a peptide; …
-
A Critical Role Of Cxcr2 Pdz Motif-Mediated Interactions In Endothelial Progenitor Cell Homing And Angiogenesis
… affect the functions of EPCs. Moreover, biochemistry study suggested that NHERF1, a PDZ domain containing scaffolding protein, preferred to interact with CXCR2 and its downstream effector, PLC-β3 in EPCs. Taken together, the data has demonstrated the role of CXCR2 PDZ motif-mediated …
Page 1 of 4