Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Biochemistry, Molecular Bio, and Biophysics"”.
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Conformational changes in actinin-type actin binding domains: probing actin-induced structural dynamics in dystrophin and utrophin using EPR spectroscopy.
The underlying cause of Duchenne and Becker muscular dystrophies is a lack of functional dystrophin, a large multidomain protein. Dystrophin is normally expressed in muscle, where it links the extracellular matrix to the cortical actin cytoskeleton via a complex of associated proteins. Dystrophin, …
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Structural studies of the deaminase domain of the human HIV-1 restriction protein APOBEC3G
… HIV can lead to AIDS, which is a set of symptoms and infections resulting from the damage to the human immune system. However, due to the rapid mutability and productivity of the HIV, identifying treatments and therapeutic intervention remains challenging and has seen limited progress. In the past …
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Mcm10 regulates the turnover of DNA polymerase alpha.
Accurate and efficient duplication of the genome exactly once per cell cycle is crucial for prolonged health of an organism. Minichromosome maintenance (Mcm) 10 is an essential, highly conserved replication factor with multiple functions at the fork. Critical for Mcm10's role at the fork is its DNA …
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Beyond the allosteric role of Fructose-2,6-bisphosphate: exploring its effects on gene expression and signal transduction.
… ameliorates the diabetic phenotype in type 1 and type 2 diabetic mouse models (WU et al. 2001b; WU et al. 2002). This is attributed to the well characterized allosteric effects F26BP has on glucose metabolism enzymes. Recent studies have determined that raising F26BP levels has an additional …