Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 290 for “"Biochemistry, Biophysics, and Structural Biology"”.
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MOLECULAR MECHANISMS OF THE FORMATION OF ENDOCYTIC PATCHES AND THE INITIATION OF ACTIN POLYMERIZATION IN FAST ENDOPHILIN MEDIATED ENDOCYTOSIS
… of a varietyof cargo including macronutrients and transmembrane receptors. Fast endophilin mediated endocytosis (FEME) is a clathrin independent endocytic pathway that is responsible for the uptake of numerous receptors, many of which are major drug targets, including the exclusive uptake of …
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SORTASE AND CHEMICAL BIOLOGY AS TOOLS TO STUDY UBIQUITINATION
… protein trafficking, cell signaling cascades, and gene expression. Despite nearly 50 years’ worth of scientific research, many questions still surround the impacts and roles of protein ubiquitination due to limitations in the current technologies available to study the role of this common …
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MOLECULAR MECHANISMS OF ACTIN FILAMENT ASSEMBLY AND TURNOVER
… locomotion, endocytosis, mechano-transduction, and many other essential cellular functions. This versatility stems primarily from the myriads of actin binding proteins (ABPs) that bind to and regulate actin. A substantial proportion of these proteins modify actin turnover at filament ends, …
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DROSOPHILA CLASS-I MYOSINS THAT CAN IMPACT LEFT-RIGHT ASYMMETRY HAVE DISTINCT ATPASE KINETICS
… dysregulation can lead to development defects and diseases. In this dissertation, we focus on unraveling the molecular mechanisms of two class-I myosin paralogs, myosin-1C (myo1C) and myosin-1D (myo1D), that can impact Drosophila Left-Right asymmetry. De novo overexpression of either paralog in …
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MOLECULAR REGULATION OF ATP-CITRATE LYASE
… acetyl-CoA outside the mitochondria and is an attractive therapeutic target for metabolic disorders and cancer. In the cytosol, acetyl-CoA is used for lipid synthesis and is also the essential substrate for protein acetylation. In the nucleus, acetyl-CoA is used for histone …
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MULTIPLE STRATEGIES IN COMPUTATIONAL PROTEIN DESIGN: STRUCTURAL INTUITION, PROBABILISTIC INVERSE FOLDING, AND GENERATIVE APPROACHES
Designing proteins with specific structural and functional features has become increasingly feasible through the integration of physics-based modeling, statistical inference, and generative algorithms. This work presents conceptual, methodological, and applied examples spanning multiple stages of …
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UNDERSTANDING HEPATIC REV-ERBa INTERACTING PARTNERS AS IT PEAKS AND TROUGHS THROUGH THE CIRCADIAN DAY
… will find a body of work that describes new and exciting data about the nuclear receptors REV-ERBa and REV-ERBREV-ERBs are interesting proteins to understand because they play important roles in the circadian clock and in the regulation of metabolism on a variety of tissues. Understanding …
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Structural and Dynamic Proximal Proteomic Analysis of TRPV2 Ion Channel Activation
… such as immune response, neuronal development, and multiple cancers. Despite the impact of TRPV2 on varying physiologies, there is still much to be resolved about the ion channel. One key aspect of understanding the channel’s function is to establish a structural basis for TRPV2 pharmacological …
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Newly Synthesized Pyroglutamate Amide and its Neuroprotective Effect Against Neurotoxicity Induced Cell Death in Alzheimer's Disease
… disease (AD), which represents 60 – 70% of cases and it ranked fourth cause of mortality in the USA. In Alzheimer’s disease, glutamate released from astrocytes and activates extrasynaptic N-methyl-D-aspartate (NMDA) receptors and triggers pro-apoptotic signaling that overcomes synaptic NMDA …
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A Phytochemical Analysis of Secondary Metabolites in Eupatorium Serotinum
… in medicinal research due to the distinctive and unique properties of natural compounds. All metabolites are produced from the metabolic cycle, which is a pathway that provides energy for the organism. These metabolic compounds vary greatly and are classified based on their function within the …
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REGULATION OF YKL-40 IN STERILE INFLAMMATION AND ITS ROLE IN GLIOBLASTOMA IN VIVO
… is a shared biomarker of chronic inflammation and oncogenic transformation. Indeed, YKL-40 expression is up-regulated in many diseases including multiple sclerosis, Alzheimer disease, viral encephalitis, HIV-associated dementia, brain infarction, and traumatic brain injury. YKL-40 is also …
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MECHANISMS BY WHICH XRCC3 MEDIATES BREAST CANCER CELL INVASION VIA CYCLOPHILIN A
… invasive T4-2 cells enhances cell invasiveness and increases FAK activation and signaling. This effect is abolished by EGF or TGFβ suggesting that XRCC3 is upstream of these factors. Conditioned media (CM) from XRCC3-downregulated T4-2 cells enhances the invasion of naïve pre-invasive and …
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DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS
… is present at elevated levels in the blood and ascites of ovarian cancer patients. LPA is a ligand of seven cell surface G protein-coupled receptors. It has been known as an oncogenic growth factor in ovarian cancer and other types of human malignancies. However, the precise biological …
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THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… an immune response that recognizes, sequesters and eradicates invading infectious agents. Critical to this safeguard is the receptor-mediated detection of pathogens. Pathogen recognition then initiates a variety of signaling cascades that lead to the modulation of genes orchestrating an immune …
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Determining the mechanism of double-stranded RNA-induced cell death in ovarian cancer.
… ovarian cancer drug regimens, including taxanes and platinum-based agents, are susceptible to chemoresistance necessitating the development of novel chemotherapeutics. Within tumors pathogen-derived ligands, such as dsRNA, can activate pattern recognition receptors (PRRs) that are capable of …
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
… differentiation, survival, apoptosis and immune responses. Aberrant activation of this pathway mediates neoplastic transformation and abnormal growth of many malignancies including breast cancer, the most common cancer among women, and the second leading cause of cancer deaths in women …
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CBL and CBL-B Dictate CSF-1R Endocytic Traffic and Signaling in Macrophages
… tyrosine kinase essential for the growth and function of macrophages. Understanding the mechanisms that regulate CSF-1R activation and deactivation will provide insights to clinical treatment of macrophage related diseases including chronic inflammation and cancer. Previously, our …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
Matrix stiffening and external mechanical stress have been linked to disease and cancer development in multiple tissues, including the liver, where cirrhosis (which increases stiffness markedly) is the major risk factor for hepatocellular carcinoma (HCC). Stiffness is correlated with cancer …
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