Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Biochemical recurrence"”.
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Diagnostic and Prognostic Biomarkers for Early Prostate Cancer
… associated with prostate cancer grade group and biochemical recurrence. Loss of the PTEN tumor suppressor is a powerful prognostic biomarker in prostate cancer. However, the significance of tumour heterogeneity and partial PTEN loss are not clearly defined, nor are interactions between PTEN loss …
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Imunologiniai atvirų ir laparoskopinių prostatos vėžio operacijų skirtumai /
… lympho-node status) as well as the risk of biochemical recurrence. We found, that Laparoscopic Radical Prostatectomy (LPR) technique resulted in complete restoration of T cell, NK, CTL. Also the immunosuppressive compartment (MDSC) did not reveal any upregulation in the postoperative period …
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SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1
… diagnosis and decreased time to metastasis after biochemical recurrence. Previously, SOX2 was found to promote lineage plasticity and resistance to AR-targeted therapies in prostate cancer. Further, the SOX2 protein is either present or absent in a prostate cancer tumor, making it an ideal …
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IDENTIFICATION OF NCAM1 AS A NOVEL PROGNOSTIC PROSTATE CANCER STEM CELL BIOMARKER
… marker for predicting distant metastasis and biochemical recurrence and its expression in radical prostatectomy biopsies concurred with diagnostic biopsies (concordance 87.6%). Using the human cell lines, LNCaP (androgen-sensitive) and DU145 (androgen-insensitive), we found that NCAM1, but not …
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Cirkuliuojančių prostatos vėžio imuninių veiksnių prognostinis vaidmuo /
… of sPD-L1 and sPD-L1 molecules on disease recurrence and tumour aggressiveness, to determine the relationship between sPD-1 and immune parameters, and to analyze the association between sPD-L1 and immune parameters in patients with favourable and unfavourable prognosis. sPD-1 and sPD-L1 …
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Detecting prostate cancer metastases - PET/CT and the sentinel node technique
… of early choline PET/CT in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) was evaluated in Study III. SN detection was prospectively evaluated and compared with ePLND in Study IV. The main results were: 1) A fifth of patients with high-risk prostate cancer and …
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Role of Wnt5a in Prostate Cancer
… of Wnt5a protein in tumor cells had longer biochemical recurrence free time compared to patients with low Wnt5a protein expression. We demonstrated that this effect may be explained by the ability of Wnt5a to impair invasion in prostate cancer cells as recombinant Wnt5a treatment decreased …
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The identification of prostate cancer associated tumour antigens and biomarkers
… enolase may serve as a potential indicator of biochemical recurrence in PCa. PROTEOMEX represents a valuable approach for the identification of tumour biomarkers which may have diagnostic and/or prognostic value in PCa. Further work should identifiy more TAAs and autoantibodies associated with …
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Examining the Role and Regulation of Cell-Cell Adhesion in Aggressive Prostate Cancer
… was found to be significantly associated with biochemical recurrence demonstrating their potential utility as prognostic markers of aggressive prostate cancer.
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A PHASE III PROSPECTIVE RANDOMIZED TRIAL TO EVALUATE THE IMPACT OF AUGMENTED REALITY DURING ROBOT-ASSISTED RADICAL PROSTATECTOMY ON THE RATES OF POSTOPERATIVE SURGICAL MARGINS
… between the two groups. No differences in biochemical recurrence (BCR) or erectile function recovery over time were recorded. At ex-vivo FCM, the inter-observer agreement between pathologists ranged from moderate (k=0.74) to almost perfect (k=0.90). For a highly experienced pathologist, a …
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Clinical and biological validation of hyperpolarised MRI of prostate cancer
… 13C label between pyruvate and lactate, a biochemical reaction traditionally viewed as the metabolic hallmark of aggressive cancers. The first-in-man study of the technique showed increased [1-13C]lactate labelling in PCa areas compared to the benign prostate, with more recent studies …
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Development of a standardized functional soy product for cancer prevention trials:Phase II evaluation of isoflavone bioavailability in men with asymptomatic prostate cancer
<p>Soy isoflavones have generated substantial interest in the last few decades. However, bioavailability, metabolism, bioactivity and structural fate of isoflavones have been the subject of much stimulating discussion. Of the many dietary variables of interest, diets rich in soy foods are …
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The role of tomato and lycopene consumption on prostate carcinogenesis and prostate cancer treatment
… PCa and treatment-associated outcomes (such as biochemical recurrence and cachexia). In summary, this dissertation has contributed novel findings to our understanding of the interactions between tomato products and PCa.