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Showing 1 to 20 of 22 for “"Biochemical pathway"”.

  1. The Biochemical Pathway Leading to Lpa Generation Upon Blood Coagulation

    Bolen, Alyssa Lynn Jefferson2016

    … 20:4 lysophosphatidic acid (LPA) production. The biochemical pathway responsible for LPA production during blood clotting is not fully understood. We have purified a phospholipase A<sub>1</sub> (PLA<sub>1</sub>) from thrombin-activated human platelets using sequential chromatographic steps …

    tenn-hsc Repository record

  2. Engineering a Reverse C4 Photosynthetic Pathway in C3 species Arabidopsis thaliana

    Di, ZhengaoUniversity of Cambridge2022

    … to replicate the spatial patterning of the C4 biochemical pathway but make use of the native leaf anatomy of C3 species. The main objective of this thesis was to test if introducing a reverse C4 photosynthetic pathway in C3 Arabidopsis thaliana could improve its photosynthetic efficiency. Two …

    cambridge Repository record

  3. Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes

    Dean, Pamela MaryDepartment of Chemistry2004

    … symptoms are brought about by the action of biochemicals such as prostoglandins, which result from the conversion of a fatty acid, known as arachidonic acid, by the enzyme cyclooxygenase (COX) in the presence of oxygen. NSAIDs act on this biochemical pathway by inhibiting the COX enzyme, …

    cape-town Repository record

  4. Prorenin, its maturation and the (pro)renin receptor

    L'Huillier, NathalieThe University of Edinburgh2007

    The renin-angiotensin system (RAS) is a key biochemical pathway controlling homeostasis and blood pressure. The initial step of the RAS is carried out by renin to produce angiotensin (Ang) I which is converted to Angll by the angiotensin-converting enzyme (ACE). Renin is synthesized as a pro-enzyme …

    edinburgh Repository record

  5. Mathematical modelling of autophagy pathway.

    Zebrowska, MagdalenaNational University of Ireland Maynooth2010

    … Current understanding of each step in this biochemical pathway is limited. The study of this mechanism is interesting in several aspects: autophagy plays an important role in physiological cellular processes, is a survival mechanism under external stress and is also connected with cancer and …

    maynooth Repository record

  6. Improved tracking of phosphorus in wastewater treatment works through anaerobic digestion of p-rich sludge

    Quevauvilliers, MatthieuDepartment of Civil Engineering2021

    … but was unable to conclusively identify a single biochemical pathway for PAO processes.

    cape-town Repository record

  7. Comparison of optical density, total cell protein, and number of viable cells (via fluorescent straining) as measures of microbial growth kinetics in suspended and biofilm cultures during biodegradation of naphthalene

    Shim, Jeong Seop

    … require more detailed kinetics of the actual biochemical pathway.

    njit Repository record

  8. Silencing the host : the role of intronic microRNAs

    Hinske, Ludwig Christian GiuseppeMassachusetts Institute of Technology2009

    … information to target prediction, with biochemical pathway information and publicly available expression data to investigate functional properties of intragenic miRNAs and their relationship to their host genes. To the best of our knowledge, we are the first to show in a large-scale …

    mit Repository record

  9. Changes in Kinetochore Structure and Molecular Composition in Response to Mis-attachment

    Shen, MuyaoVirginia Tech2011

    … MTs from opposite spindle poles) attachments. A biochemical pathway named the Spindle Assembly Checkpoint (SAC) is responsible for delaying anaphase onset to allow correction of KT mis-attachments. SAC activation is believed to occur due to KT localization of certain SAC proteins and/or lack of …

    vt Repository record

  10. Novel extracellular products of Mycobacterium tuberculosis: composition, synthesis, and relevance to disease

    Obregón-Henao, Andrés, author, Belisle, John T., advisor, Brennan, Patrick J., committee member, Curthoys, Norman P., committee member, Dow, Steven W., committee memberColorado State University. Libraries2013

    … III and IV were devoted to identifying the biochemical pathway involved in &alpha;-L-polyGlutamine (&alpha;-L-polyGln) biosynthesis and determining its role in pathogenesis in the murine model of TB. &alpha;-L-polyGln is an Mtband Mycobacterium bovis (M. bovis) specific product and its …

    colostate Repository record

  11. Investigating the role of ALDH3B2 and FUT2 as potential risk genes to colorectal cancer through computational analysis and gene expression study of colonic cells, and utilizing colorectal cancer cell lines to explore gene-environment interactions

    Medema, Alexis MarieThe University of Edinburgh2019

    … a fucosyltransferase that is central to the biochemical pathway responsible for the expression of the A and B antigens in non-blood bodily fluids. At least three transcript forms of FUT2 were identified in CRC cell lines. Differences in allele-specific expression of the well-documented …

    edinburgh Repository record

  12. Identifying and dissecting novel QTL regulating seed fatty acid composition in Arabidopsis thaliana for the improvement of rapeseed oil

    Hattori, ChieUniversity of East Anglia2012

    … in the polyunsaturated fatty acid (PUFA) biochemical pathway have been identified by mutation analyses and utilized in oilseed rape (Brassica napus) breeding programs. However the regulation mechanisms of these genes are as yet unknown and pursued by the oil industry for further …

    east-anglia Repository record

  13. Genomic Organization of Fatty Acid Desaturase-2 (Fad2 ) and Fatty Acid Desaturase-6 (Fad6) ESTs in Maize

    Mikkilineni, VenugopalUniversity of Illinois at Urbana-Champaign2015

    … and functional value of corn oil. The biochemical pathway for fatty acid biosynthesis indicates that a single enzyme, the delta12 desaturase, converts oleic (18: 1) to linoleic (18:2) by inserting a double bond at the delta-12 position. Fatty acid desaturase-2 (fad2) converts the oleic …

    uiuc Repository record

  14. The Differential Contribution of Striatonigral and Striatopallidal Neurons in Mediating Responses to Therapeutic Agents and Drugs of Abuse: A Dual Role for DARPP-32

    Bateup, Helen S

    … sends projections to the output nuclei via two pathways, the direct striatonigral pathway and the indirect striatopallidal pathway. These two pathways work together to modulate behavior and imbalance of these pathways can have profound physiological consequences. DARPP-32 is a dual function …

    rockefeller Repository record

  15. Computational analysis of biochemical networks for drug target identification and therapeutic intervention design

    Paudel, NirmalaMassachusetts Institute of Technology2014

    … to exhaustively evaluate target behaviors in biochemical network, either as single agent or combination therapies. We present our single target therapy work as a problem of identifying good places to intervene in a network. We quantify a relationship between how interventions at different …

    mit Repository record

  16. Biochemistry and genetics of the pathway for the anaerobic degradation of aromatic compounds by Eubacterium oxidoreducens

    Haddock, John DavidVirginia Tech1990

    The biochemical pathway for the anaerobic degradation of gallate, pyrogallol and phloroglucinol by Eubacterium oxidoreducens was investigated. Phloroglucinol reductase was purified 90-fold, from the soluble fraction of cell extract, to electrophoretic homogeneity. The enzyme was an α₂ homodimer …

    vt Repository record

  17. The Functions of Autophagy Genes in Lymphocytes and Osteoclasts

    Miller, Brian2010

    … proteins and organelles. The autophagy pathway and autophagy genes have been implicated in many functions in the cell such as protecting against metabolic stress, degrading damaged organelles, and regulating vesicular trafficking. To study the role of autophagy in primary cells with …

    wustl Repository record

  18. Manipulation of ascorbic acid levels in Arabidopsis thaliana

    Radzio, Jessica A.Virginia Tech2003

    … and fatty acids from oxidation. Although the biochemical pathway in animals has been known since the 1950's (Jackel et al., 1950), the exact process by which ascorbic acid is made in plants has eluded scientists. It was shown in 1963 that the inversion of the hexose carbon chain, which occurs …

    vt Repository record

  19. Structurally coloured bacterial colonies

    van de Kerkhof, GerdaUniversity of Cambridge2021

    … all from the same taxonomic class, and the biochemical pathways that regulate these colours remain completely unknown. Here, several open questions regarding structural colour in bacterial colonies have been explored. First, a combination of an experimental and theoretical toolset that …

    cambridge Repository record

  20. Structural studies of Burkholderia pseudomallei invasion protein D (BipD), 2,4'-dihydroxyacetophenone dioxygenase (DAD) and L-threonine dehydrogenase (TDH)

    Bowyer, AlexandraUniversity of Southampton2008

    … about the enzymes involved in aromatic catabolic pathways will result in a better understanding of the whole system and therefore present opportunities for manipulation for bioremediation purposes.<br/><br/>Knowledge of a protein’s structure can also help identify how specific properties are …

    soton Repository record

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