Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"Biochemical Phenomena, Metabolism, and Nutrition"”.
-
Novel Therapeutic Targets Identified By High-Throughput Technologies For Triple-Negative Breast Cancer
… lack of or reduced expression of the estrogen and progesterone receptors, and normal expression of the human epidermal growth factor receptor 2. The lack of a well-characterized target for treatment leaves only systemic chemotherapy as the mainstay of treatment. Approximately 60-70% of patients …
-
The Role of the Parotid Salivary Glands in the Regulation of Insulin Secretion
<p>Stress of handling, partial or complete sialoadenectomy, and the administration of parotid hormone (PH), sodium fluoride (NaF), or guanidino-succinic acid (GSA) were examined for effects on fasting plasma glucose and insulin or effects on intravenous glucose tolerance in male Sprague-Dawley …
-
The Effect of Exercise on Metabolic Rate with Time in Overweight and Normal Weight Subjects
… study was designed to investigate changes in BMR and metabolic rate with time for normal weight and overweight subjects involved in a practical exercise program. The relationship of changes in BMR and metabolic rate in coping with the problems of obesity were also studied.</p> <p>Fifteen subjects, …
-
The Effect of a PUFA Diet on Human Red Blood Cell Levels of 2, 3-DPG
… blood was collected at weekly intervals and the level of 2,3-DPG of the red blood cell was determined in 15 male subjects age 28 to 57 with serum cholesterol levels greater than 250 mg%. A lactovegetarian diet containing no cholesterol, a high level of dietary fiber and a P/S ratio of 4.0 …
-
Some Aspects of Carbohydrate Metabolism in the Cercariae of SCHISTOSOMA MANSONI Sambon, 1907
… glucose from solution, lactic acid production, and respiration.</p> <p>Using the anthrone method of determination of carbohydrate, the amount of glycogen used by a single cercaria in 4 hours is determined as 43.2 x 10<sup>-4</sup> μg ± 6.6 x 10<sup>-4</sup> μg.</p> <p>Glucose was not observed to …
-
Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… by increasing its reliance on glucose and structurally by increasing the size of myocytes. Whether changes in metabolism regulate the structural remodeling process is unknown. A likely candidate for a link between metabolism and growth in the heart is the mammalian target of rapamycin …
-
The Tca Cycle As A Nexus of Metabolic Vulnerabilities In Cancer
… of metabolic pathways to meet biosynthetic and bioenergetic demands of proliferation and fortify redox homeostasis. An increasing body of literature suggests that mitochondrial metabolism (tricarboxylic acid cycle (TCA) and oxidative phosphorylation) is imperative for cancer cell growth and …
-
Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… was confirmed by direct metabolite analysis and [U-<sup>13</sup>C]-glucose tracing analysis. Together, these studies indicate that the brain TME mediates OXPHOS enrichment in MBMs.</p> <p>The functional significance of OXPHOS in MBM pathogenesis was tested using IACS-010759, a potent OXPHOS …
-
Pam2ODN-Induced Epithelial Resistance Against Influenza A Requires STAT3 Activation
… (LRTIs) remain a leading cause of morbidity and mortality worldwide, with the immunocompromised patient population at greatest risk. In the setting of emerging infections and escalating antimicrobial resistance, there is an urgent need for novel strategies to protect susceptible patients …
-
An Interface of the Taste and Reward Systems in the Brainstem and Its Role in Feeding
… (e.g., vegetables) are often less appetizing, and the tastiest (e.g., fast food, ice cream) may be the least healthy. Despite the former, we may also have a lower limit of what we accept at which point nutrition becomes irrelevant (e.g., “spinach is just too yucky”). Further, we may eat …
-
Effect of Isocaloric Unsaturated Fats on Serum Cholesterol of Patients Treated with Hypocholesterolemic Agents
… acid (Diac), dextrothyroxine (d-T<sub>4</sub>) and 3-methoxy-16, alpha-methyl-1,3,5, (10)-estratriene-16 beta, 17 beta-diol (Manvene or Anvene).</p> <p>Fifteen hypercholesterolemic patients, eleven of whom were diabetic, were placed on diets with prescribed amounts of unsaturated fat. The …
-
The New Role of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, and Autophagy
… gene, playing an important role in LDL metabolism. Gain-of-function mutations of <em>PCSK9</em> lead to hypercholesterolemia and loss-of-function mutations of <em>PCSK9</em> are associated with decrease of LDL cholesterol. The effects of PCSK9 on cholesterol levels are the consequence of …
-
Targeting Metabolic Adaptations to Anti-Angiogenic Therapy In Ovarian Cancer
… adaptive resistance is nearly ubiquitous and additional therapeutic options are limited. A dependence on glutamine metabolism, <em>via </em>the enzyme glutaminase (GLS), is a known mechanism of adaptive resistance.</p> <p><strong>Purpose: </strong>To assess the efficacy of a glutaminase …
-
Effect of Monounsaturated Fat Rich Almonds on Hemostatic and Inflammatory Factors in Healthy Adults
… cardiovascular disease by reducing serum total and low-density lipoprotein (LDL) cholesterol. Markers of inflammation including C-reactive protein, E-selectin and interleukin-6 have been proposed to be newer risk factors for cardiovascular disease. However, the influence of nuts such as almonds …
-
The Effects of Curcumin On Body Composition of Patients With Advanced Pancreatic Cancer
… among patients with advanced pancreatic cancer and is a marker of poor prognosis. Weight loss in cachexia is due to both adipose and muscle compartments, and sarcopenia (severe muscle depletion) is associated with worse outcomes. Curcumin has shown a myriad of biological effects, including …
Page 1 of 2