Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 86 for “"Biocatalysis"”.
-
ACCELERATING WHOLE-CELL BIOCATALYSIS BY ENHANCING OUTER MEMBRANE PERMEABILITY
Whole-cell biocatalysts are preferred in many biocatalysis applications. However, cell envelope often represents a formidable permeability barrier. As a result, reactions catalyzed by whole-cells are reportedly orders of magnitude slower than those of by their free enzyme counterparts. The present …
-
Toward a General Dehydrogenase Enzymatic Scaffold for Industrial Biocatalysis
Enzymes catalyze a wide range of reactions with high efficiency and exquisite specificity. As such, they lend themselves well for use in a myriad of applications from the production of fine chemicals to use in biofuel cells. Demand for enzymes with novel specificities has risen in recent years, as …
-
Intensified biocatalysis for production of fuel and chemicals from lipids.
Triglycerides are abundant biorenewable resources found in vegetable oils and fats. The effective utilization of triglycerides is one of the key interests in developing renewable fuels and products. However, triglycerides are difficult and inefficient to be used as fuels directly in regular …
-
Production of bio-active compounds from ferulic acid using biocatalysis
Includes bibliographical references (p. [181]-203).
-
A Strategic Framework for Evaluating Next-Generation Technologies in Biocatalysis
The emergence of a new wave of biocatalysis innovation is rapidly transforming the pharmaceutical industry. This next generation of techniques, characterized by metagenomics, artificial intelligence, and computational modeling, is reshaping approaches to process development for companies operating …
-
Directed evolution of amino acid dehydrogenases for biocatalysis of chiral amines
… the engineering of amino acid dehydrogenases for biocatalysis of chiral amines, focusing on two crucial features for successful directed evolution experiments. A first key aspect is the development of technologies allowing the screening of large libraries of enzyme variants to explore sequence …
-
The design and synthesis of a novel thiamine cofactor for potential biocatalysis
The design and application of enzyme mimics has received more attention due to requirement of green chemistry applications within industry and academia. One way of introducing these modifications is via a cofactor, due to their location within an enzyme’s active site. A number of crucial …
-
Exploiting yeast diversity in whisky fermentations for biocatalysis of desirable flavour compounds
Yeast is an important component in producing flavourful fermented products. The Scotch Whisky industry currently only uses four different yeast strains all belonging to <i>Saccharomyces cerevisiae</i>. In recent years, the brewing and wine industries have proven that a variety of yeasts can impart …
-
Stereoselectivity, kinetics, and engineering of flavin/deazaflavin oxidoreductases for use in industrial biocatalysis
… challenging in chemosynthesis, find relevance in biocatalysis. Moreover, traditional chemical synthesis continues to face concerns about environmental costs and viability. Biocatalysts, such as enzymes, can address both concerns due to their high specificity and inherent renewability, as well as …
-
Stereoselectivity, kinetics, and engineering of flavin/deazaflavin oxidoreductases for use in industrial biocatalysis
… challenging in chemosynthesis, find relevance in biocatalysis. Moreover, traditional chemical synthesis continues to face concerns about environmental costs and viability. Biocatalysts, such as enzymes, can address both concerns due to their high specificity and inherent renewability, as well as …
-
OPPORTUNITIES AND CHALLENGES OF BIOCATALYSIS IN PHARMACEUTICAL SCIENCES: DEVELOPING TAILORED BIOCATALYSTS FOR SYNTHETIC APPLICATIONS
Biocatalysis has emerged as a powerful and sustainable alternative to traditional chemical synthesis, particularly in the preparation of stereochemically complex pharmaceutical intermediates. This doctoral research focuses on the development of tailored biocatalysts, specifically amine …
-
Biocatalysis on nanostructured surfaces : investigation and application of redox proteins using spectro-electrochemical methods
In this thesis, different aspects within the research field of protein spectro- and electro-chemistry on nanostructured materials are addressed. On the one hand, this work is related to the investigation of nanostructured transparent and conductive metal oxides as platform for the immobilization of …
-
Beyond bottlenecks: expression of complementary enzymes and permeabilization of cell membranes to improve performance of CYP153A6 in Escherichia coli whole cell biocatalysis
… of hydrocarbons emerged as the key limitation in biocatalysis by CYP153A6 in whole cells. This limitation could be alleviated by permeabilising the cell. Mechanical breakage of the cell envelope was particularly effective, but this in turn impacted negatively on the cell's ability to maintain its …
-
The development and improvement of biocatalytic reactions
… for 'green', environmentally friendly processes. Biocatalysis, using enzymes to catalyse a chemical reaction, is emerging as an economical and ecological production route for a wide range of fine chemicals, pharmaceuticals and food ingredients. In addition to biocatalysis, miniaturised chemistry …
-
FROM AGRI-FOOD WASTE TO HIGH-VALUE COMPOUNDS VIA GREEN TECHNOLOGY APPROACHES
In the framework of sustainable biocatalysis and circular bioeconomy, this thesis explores the development of innova:ve enzyma:c strategies for the valoriza:on of agri-food by- products into high-value compounds. Four complementary approaches were pursued, each focusing on process intensifica:on, …
-
Engineering outer-membrane electron transfer proteins for modular biotic-abiotic interfacing with living cells
… biofilms, and redox enzymes for biosensing or biocatalysis. Furthermore, I demonstrate that the N-terminus of MtrA can be modified without disrupting EET. Fusion of a P450 heme domain to MtrA facilitated microbial electrosynthesis driven by EEU from an extracellular cathode. This intracellular …
-
Upgrading alcohols with bio-oxidation and chemo-catalysis in single-flask processes
Biocatalysis provides exquisite chemo-, regio-, and stereo-control, built-in co-factor regeneration, and can upgrade renewable feedstocks through multi-step transformations, all while avoiding high temperatures, organic solvents, and metal catalysts. Despite these marked advantages over …
-
Engineering novel tandem reactions using organometallic catalysts and (metallo)enzymes
… organometallic catalysis, organoca-talysis and biocatalysis. Over the years, catalysts of these three classes have enabled ground-breaking chemical transformations. The application of chemocatalysis to the manufacturing of chemicals is widespread, and biocatalysis is increasingly being used …
Page 1 of 5