Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"Biobank"”.
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Biobank for America
… dollars into patented pharmaceuticals. The Biobank for America does just that by making transparent the collection and storage of biometric information on a national scale and finally collating it into a comprehensive, searchable archive.
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A contemporary history of the origins and development of UK Biobank, 1998-2005
… examines the origins and early development of UK Biobank. This is a resource funded in 2002 by the Medical Research Council, the Wellcome Trust, the Department of Health and the Scottish Executive to gather genetic and lifestyle information from half a million participants aged 4069 years old in …
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A Genome-Wide Association Study on Widespread Pain using the UK Biobank Cohort
… with widespread pain in a cohort of UK Biobank participants who had completed a pain phenotyping questionnaire.<br/><br/><b>Method</b>: Cases and controls were determined by a question answered by UK Biobank participants. The question contained 10 selections to identify different pain …
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Pilot-scale production and physicochemical properties of mycelium-based materials and diversity assessment of a fungal biobank
… the mycelium bricks. We also characterized our biobank of commercial and locally sourced wild fungal cultures in terms of species diversity to inform future testing for mycelium-based material production. Species boundaries were delineated using ITS sequences, providing a foundation for …
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Genetic Determinants of Human Susceptibility to Infections: A Multi-faceted Exome-based Analysis in the UK Biobank
… three interconnected studies utilising UK Biobank datasets. These studies investigate the relationships between genetics, exomes, and immune responses, focusing on serological antibody responses to common pathogens, broader phenotypic effects of infection-related genetic variants, and …
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CHARACTERISTICS OF CLINICAL NONTYPHOIDAL SALMONELLA ISOLATES FROM A HISTORICAL BIOBANK WITH A FOCUS ON THE INVASIVE SEROTYPE CHOLERAESUIS, LOMBARDY REGION (2001-2016)
… control. In this context, analyses of historical biobanks of clinical Salmonella strains represent an invaluable tool to improve knowledge of the biological, clinical, and epidemiological characteristics of the pathogen, as well as to investigate pathogenicity and antimicrobial resistance …
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Epidemiological investigations of liver cancer: biomarkers, reproductive factors and modifiable risk factors:
… Unit (PCCIU) and a cohort study using UK Biobank. We found an increased risk of liver cancer, especially of intrahepatic bile duct carcinoma in proton pump inhibitors users but not in histamine-2 receptor antagonists users. This novel association requires further research to determine …
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Clinical Drug-Gene and Drug-Drug-Gene Interactions for the Most Commonly Used Chronic Drugs in the UK
… Using the UK Biobank (cross-sectional) cohort and 3 other Scottish cohorts (longitudinal), I have studied the association of 162 genetic variants in important genes with three drug response phenotypes for the 50 selected drugs/combinations. This has generated a …
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Research biobanks: mixed consent as the prerequisite for the freedom of biomedical research /
The purpose of the research biobanks is to collect human biological samples and the related information important for biomedical research, which in the future can be used for comprehensive scientific research. Such research would assist in creating new medicine, acquiring knowledge on the …
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Environmental Toxins and Essential Trace Elements at Delivery and ADHD
… fetal growth and development. Register and biobank based case-control studies were conducted to investigate the relationship between prenatal exposure to these chemicals and attention deficit hyperactivity disorder (ADHD) in childhood. The study base comprised children born in Malmö, Sweden, …
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Investigating Inflammatory Pathways in Alcohol-Associated Liver Disease
… of drinking, liver iron and liver fat in a UK BioBank cohort. Results show 350 mM ethanol led to a 50% decrease (p<0.0001) in cell viability at 72 hrs and a significant increase in ROS at 30 mins (p=0.0027). At 72 hrs a substantial number of cells were late apoptosis (44%) (p=0.0153) as well as …
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Detection, causes and consequences of sex chromosome mosaicism
… 2, in genetic data derived from 205,604 UK Biobank males and 243,765 females, the new method improved the accuracy of LOY/LOX estimation as measured by the strength of association between LOY/LOX and age, smoking status, and polygenic risk of LOY/LOX derived from previous GWAS. In chapter 3, …
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Medications, sex hormones and reproductive factors in relation to gastro-oesophageal cancer risk and survival
… (PCCIU) database and a cohort study using the UK Biobank to assess the association between acid-suppression therapy and gastro-oesophageal cancer risk. The finding showed an increased risk of gastro-oesophageal cancer in patients using proton pump inhibitors and/or histamine-2 receptor antagonists …
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Study of prognostic markers in advanced cancer
… review, an analysis of a prospectively collected biobank of patients with lung cancer and finally a large de novo multi-centre (UK) observational cohort study (Inflammatory biomarkers in Prognosis in Advanced Cancer [IPAC] study), were undertaken. The latter examined prognostic factors and was …
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Integrative mathematical modelling of drug responses in breast cancer PDTXs and ex vivo PDTCs
… vivo PDTX-derived tumour cells (PDTCs). A robust biobank of over 100 PDTXs, encompassing diverse breast cancer subtypes, was expanded and genomically characterised. This collection captures the broad heterogeneity of breast cancer, facilitating pre-clinical studies into tumour biology and …
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GENOME-WIDE ASSOCIATION STUDY OF NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS IN MASLD: EVIDENCE FROM AN ITALIAN POPULATION
… using non-invasive fibrosis markers in a large biobank environment. The analysis was performed in the Milan Biobank, a multicenter cohort of 7,025 individuals encompassing healthy blood donors, metabolic dysfunction patients, and liver disease subjects across the MASLD spectrum. Clinical …
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Unravelling the Genetics of Cerebral Small Vessel Disease
… HTRA1 and COL4A1/2 variants in 454,756 UK Biobank participants. Thirdly, I perform a case-control comparison of genomes in 13,310 participants of the National Institute for Health Research BioResource Rare Disease (NBR-RD) study to identify likely causative variants for familial CSVD in …
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Inclusive and adaptive assessment of cardiorespiratory fitness for population health research
… adaptive, and robust research. In the UK Biobank study, I develop and validate a novel approach to estimate fitness in approximately 80,000 adults who performed a risk-stratified cycle ergometer test. I then apply this method to examine associations with mortality, cardiovascular disease, …
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The genetics of cognition in Schizophrenia
… with schizophrenia. Second, data from the UK Biobank was used to investigate the common genetic determinants of WIV. Third, genetically informed factors corresponding to broad cognitive abilities were used to explore the overlap between the latent cognitive factors, schizophrenia, and …
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