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Showing 1 to 6 of 6 for “"Bioavailability enhancement"”.
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Preparation and characterization of fast dissolving pullulan films containing griseofulvin nanoparticles for bioavailability enhancement
The aim of this study is to enhance the bioavailability of griseofulvin, a model poorly water-soluble drug, via increasing drug dissolution rate through preparation of drug nanoparticle-laden, pullulan-based strip films. The work entails (i) wet-milling griseofulvin in a stirred media mill using …
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Production of stable bcs class ii drug suspensions by melt emulsification and subsequent incorporation into polymer strip films
… surface area. This increase will lead to bioavailability enhancement. However, smaller drug particles are thermodynamically unstable and tend to aggregate or grow. Therefore, proper formulation and process parameters must be chosen to keep the particles small. In this study, fine drug …
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Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery
… widely adopted approach for solubility and bioavailability enhancement of hydrophobic drugs. Cellulose derivatives have strong potential as ASD polymers. We demonstrate herein design, synthesis and structure-property relationship characterization of a new series of organo-soluble cellulose …
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Solid Dispersions in Medium-Insoluble Hydrogels for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
… promise for tackling solubility related oral bioavailability problems. However, critical parameters important to the design of these ASDs have not been fully elucidated. Thus, the first part of the present study examines design factors for ASDs based on Poly(2-Hydroxyethyl methacrylate) …
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Evaluation and enhancement of physical stability of amorphous solid dispersions
… has been to enhance the dissolution rate and bioavailability of poorly water-soluble drugs.[1],[2] The amorphous forms of APIs have attracted considerable attention as the amorphous forms tend to exhibit significantly higher levels of supersaturation in aqueous media when compared to the …
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Assessment of nanocomposites vs. amorphous solid dispersions for dissolution enhancement of bcs class ii drugs
… formulation platforms used for the bioavailability enhancement of poorly water-soluble drugs. While they both have several advantages-disadvantages, a scientific comparative assessment of their drug release performance and dissolution mechanisms at different drug doses is not …