Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Bioadhesive"”.
-
Wet Adhesion and Bioadhesive Technology
… to address the challenges in wet adhesion and bioadhesive technology. The first part of this dissertation is focused on the mechanics of wet adhesion. In particular, we will systematically discuss the mechanical design principles for achieving fast tough adhesion on wet surfaces covered by …
-
SPRAY-DRIED BIOADHESIVE FORMULATIONS FOR PULMONARY DELIVERY
… delivery to the lung via dry powder inhalers. Bioadhesive formulations such as prochitosome or chitosome powders have been introduced to overcome the drawbacks of liposome instability and potentially provide significant increase in the residence time of drug in the lung. Mannitol or lactose …
-
Elucidating bioadhesive processes in nasal drug delivery systems
Mucoadhesive formulations have been used to increase the residence time and improve bioavailability of nasal dosage forms. The exact nature of the interplay between formulations and the mucus layer has not been defined, although theories have been proposed suggesting that certain characteristics …
-
The effect of precipitation techniques on bioadhesive microparticle characteristics
… technique was developed for preparing bioadhesive HPMC microparticles for nasal delivery. Aqueous gels of lactose:HPMC (1:1) were used as a model formulation, added to a precipitating solvent, and the effect of processing parameters such as stirring speed (1000-2000 rpm), needle gauge …
-
Self-assembling biomimetic hydrogels with bioadhesive properties for tissue engineering applications
… The objective of this work is to generate a bioadhesive polymer that, in addition to bonding with tissue, can support encapsulated cell survival post-adhesion. Thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) was grafted with chondroitin sulfate (CS) (PNIPAAm-g-CS) and blended with …
-
THE SYNTHESIS AND CHARACTERIZATION OF DUAL-MODIFIED CARBOXYMETHYLCELLULOSE FOR BIOADHESIVE APPLICATIONS
… motivated the development of an injectable bioadhesive system containing CMC modified with functional methacrylate and aldehyde groups that could potentially be used as an annulus fibrosus sealant or as a supplement to existing wound closure materials. After modification, the polymer was …
-
Bioadhesive Microparticles and Liposomes of Anti-Parkinson Drugs for Nasal Delivery
… drugs could be overcome by the inclusion of bioadhesive agents into formulation. The main objective of this study was to develop novel bioadhesive microspheres and liposomes entrapping the anti-Parkinson drugs ropinirole hydrochloride (RH). The microspheres were prepared via spray drying in …
-
Multiscale design of bioadhesive platforms for next-generation applications in surgery and healthcare
Bioadhesives—materials capable of adhering to biological tissues—hold significant promise as transformative tools in healthcare, offering the ability to repair tissues with ease and minimal damage. These materials present numerous opportunities in surgery and human-machine interfaces, creating a …
-
A Multifunctional Patch for Minimally Invasive Tissue Sealing: Design Strategies and Applications
Bioadhesive materials have garnered great attention due to their potential to replace sutures and staples during surgical procedures. Compared to the traditional mechanical sealing modalities, bioadhesive materials are generally associated with short application times and reduced tissue damage. …
-
Geotechnical Investigation and Characterization of Bivalve-Sediment Interactions
… strong attachment capabilities from the bioadhesives they secrete that act as a strong underwater glue, adhering their shells to granular substrate. Some species of mussels have been shown to withstand water flow velocities greater than 6 m/s without detaching. For reference, riprap with …
-
Orb weaver capture thread biomechanics and evolution
Orb weavers intercept insects using non-hardening bioadhesive droplets, supported by two flagelliform fibers. Droplets contain an adhesive glycoprotein core and aqueous layer that confers hygroscopicity. The first study investigates the durability of these droplets to cycling, or repeatedly …
-
Design and Development of Solid Lipid Nanoparticles for Ocular Delivery of Acyclovir
… were coated with the biodegradable, cationic and bioadhesive polymer, chitosan and were characterised for cytotoxicity, cellular uptake, antiviral efficiency and stability. Finally, the chosen chitosan coated NLCs formulation was subjected to an in vivo animal ocular pharmacokinetic study. …
-
Device-Enabled Biomechanical Modulation of the Infarcted Heart
… the heart. First, the in vivo performance of a bioadhesive hydrogel is optimized to allow for atraumatic coupling and facilitate minimally invasive deployment of the patches. Then, I realize a patch design and fabrication workflow that allows for custom, tunable mechanical behavior of patches …
-
Comparison of conjunctival pedicle flap to corneal adhesion achieved by Tisseel® fibrin glue, ethyl cyanoacrylate adhesive, ReSure® hydrogel sealant, and conventional suturing with 8-0 VICRYL® suture
… approaches include synthetic tissue adhesives, bioadhesives, and hydrogel sealants. The proposed advantages of adhesives over suture, include reduced operative times, watertight seals, decreased foreign-body sensation and inflammation, faster healing times and tissue regeneration with original …
-
Development of a platform for nasal delivery of peptides and vaccines using powder carriers based on starch/poly(acrylic) acid
… influenza. It was demonstrated that the use of bioadhesive carriers based on Amioca® starch and poly(acrylic acid) facilitates the induction of a systemic anti-HA antibody response after intranasal vaccination with a whole virus influenza vaccine.
-
A Novel IN SITU Gel for Sustained Drug Delivery and Targeting
… unique property of GMO is responsible for its bioadhesive property along with its ability to serve as a sustained release carrier for drug delivery. The objective of this study was to develop an in situ chitosan-GMO gel delivery system for sustained drug delivery. The good mucoadhesive property …
-
Characterisation of marama bean protein
… protein nanoparticles may also be used as a bioadhesive due to its high adhesiveness compared to soya protein and even gluten.
-
Sillica Nanoporous Materials Adsorption and Release Study
… matrix as pH stimuli because it is a well-know bioadhesive hydrogel and often used in drug formulation.</p> <p>Among mesoporous materials, SBA-15 has large surface area, large pore size, and thick walls. It possesses a hexagonal array of mesopores 6.0-20 nm in diameter, which is much larger than …
Page 1 of 2