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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Bioactives"”.
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Dietary bioactives and cardiovascular health
The primary objective of this thesis was to investigate the efficacy of dietary bioactive compounds on cardiovascular disease (CVD) risk markers in adults with mildly elevated blood pressure (BP) through the implementation of two human dietary intervention studies: the Cardio-Rubus …
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Sugar matrices in stabilization of bioactives by dehydration
… sugars. Dehydrated amorphous structures with bioactives were produced by freezing and freeze-drying. Experimental results indicated that: (i) lactose and trehalose showed similar water sorption and glass transition but very different crystallization behavior as pure sugars; (ii) the glass …
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DIETARY BIOACTIVES IN THE MODULATION OF METABOLIC, FUNCTIONAL AND AGING BIOMARKERS
… Ph.D. thesis investigates the role of dietary bioactives and bioactives-rich foods in modulating functional biomarkers of human health, with a focus on the mechanisms involving lipid metabolism, oxidative stress and inflammation, intestinal permeability, and telomere integrity. The research was …
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Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
Osteoarthritis (OA) is a disease that affects the whole joint, with progressive articular cartilage loss. Healthy cartilage must maintain a balance between extracellular matrix synthesis and degradation. Metalloproteinases (Matrix metalloproteinases, MMPs and a disintegrin and metalloproteinase …
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Reducing the risk of prostate cancer with tomato and soy bioactives
… that consuming fruits and vegetables containing bioactives such as carotenoids or isoflavones may be beneficial in reducing PCa incidence. The co-consumption of fat with carotenoids can increase their bioavailability and tissue biodistribution. Lifelong consumption of carotenoid-containing fruits …
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Effect of broccoli bioactives on prostate cancer cell invasion in vitro
Previous studies have shown that broccoli bioactives may have anti-cancer activity. In this work, we hypothesized that broccoli bioactive components inhibit invasion of human prostate cancer cell line, DU145, in an in vitro model system. DU145 cells were plated into Matrigel invasion chambers …
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Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth
Estrogen-associated cancers are a leading cause of mortality and morbidity in U.S. men and women. Consumption of cruciferous vegetables, such as broccoli, cauliflower and cabbage, is associated with reduced risk for these and other cancers. The chemoprotective properties of crucifers are …
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Enabling the discovery of novel bioactives and enzymes from billions of protein sequences
… the rapid identification of potentially novel bioactives and enzymes within MGnify. I demonstrate the platform’s utility through a series of use cases focused on enzymes capable of degrading plastics. Based on this experience and additional use cases looking at CRIPSR- Cas systems, I extended …
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Enrichment of tomatoes and broccoli with specific bioactives for the reduction of prostate carcinogenesis
… cancer preventive potential of these individual bioactives, but few have examined them within the context of a whole food. In a pilot study to evaluate bioactivity of different tomato and broccoli powders, male Copenhagen rats were fed diets containing 10% standard tomato powder, tomato enriched …
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Exploiting Chemical Libraries to Identify and Characterize Novel Bioactives with Efficacy Against Pathogenic Candida Species
Candida species are amongst the most prevalent causes of systemic fungal infections, which account for over 1.5 million annual fatalities. Candida albicans represents the most common etiological agent; however, the rate of infections caused by non-albicans Candida species continues to rise. Here, I …
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BIOBASED APPROACHES AT MODULATING THE INTERACTION BETWEEN LEGUMES BIOPOLYMERS AND BIOACTIVES: A PERSPECTIVE FOR THE PRODUCTION OF BAKED GOODS
Nowadays, with the increasing consumer demand for healthy foods, legumes, pseudocereals like buckwheat, and cereals like sorghum, have gained popularity as a potential component of functional foods. These crops are characterized by well-balanced nutritional profile, made by proteins, carbohydrates, …
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Functional Studies of Novel Bioactives From Complex Host-Microbiomes as Drug Leads for Cancer, Infectious Disease, Depression and Pain
The drug discovery process has become increasingly complex in comparison to early efforts particularly those involving diseases or conditions that affect large numbers of the human population. It is difficult to point directly to one factor leading evolution of the process but the definition of a …
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A systematic study of the effect of ultrasound on food enzymes and bioactives in model and real food systems (strawberry puree)
Ultrasound (US) technology has become of great interest in the food industry, since it can be used as an alternative to conventional thermal methods. However, there is very limited information about the effect of high frequency US on inactivation of food enzymes responsible for food quality …
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Evaluation of hops essential oil cytotoxicity and anti-cryptosporidium activity
… with controls and different concentrations of bioactives of interest (i.e. HEO and myrcene) for 24 and 48 h (37℃ and 5% CO2). To determine the anti-Cryptosporidium effect of HEO, varying concentrations of HEO or myrcene alone below their IC50 values in HCT-8 cells at 48 h were used. The …
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… a source of natural products that are rich with bioactives and have been reported to modulate inflammation, blood pressure, glucose levels and lipid profiles in both humans and animals. Currently, several known bioactives including fibers, lignans, alpha-linolenic acid, and linoorbitides (LOBs) …
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Effects of dietary fiber components and gut microbiota products on the immune system: a focus on grape pomace as a novel source of fermentable substrates and bioactives
… gut microbiota-host interactions. Polyphenol bioactives are dietary-derived metabolites. Immunomodulatory and antioxidant mechanistic behaviour of phenolics extracted from grape pomace (GP), a novel source of dietary fiber (DF), were investigated using human and rat intestinal epithelial cell …
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The Development of a Novel Technique to Evaluate Binding Between Probiotic Bacteria and Phospholipids, and the Creation of a Dairy-Based Food Product Rich in Milk Bioactives
… containing ingredient sources rich in milk bioactives. A gel-type product was created using primarily colostrum, buttermilk powder, and whey protein isolate, as well as selected strains of <em>Lactobacillus</em>. With the inclusion of immunoglobulin-rich colostrum, the product was analyzed …
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Functional characterization of pH and ultrasound treated soy protein based nanoemulsions with lutein
Delivery of lipophilic bioactives such as lutein and vitamin D into food products is challenging due to their poor water solubility. In recent years, the use of nanoencapsulation to deliver similar fat soluble bioactives has gained more attention. It is important to find a suitable, easy and cost …
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Lipid-based nutrient supplement to address child undernutrition and enteric parasitic infections in India
… activity via added oregano essential oil (OEO) bioactives. LNS were formulated using Indian staple dairy ingredients, and optimized using Response Surface Methodology (RSM) via face centered composite design with four factors and three coded levels: antioxidant (ascorbyl palmitate; at 0.0, 0.01, …
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The impact of host-microbe interactions on murine colonic secretomotor function
… probiotics elicit their effects via secreted bioactives, therefore, I studied the effects of microbially produced GABA, contained in supernatants from the commensal microbe Lactobacillus brevis DPC6108, on colonic secretomotor function. In conclusion, I believe that commensal microbes have an …
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