Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Bioactive secondary metabolites"”.
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Isolation and structure elucidation of bioactive secondary metabolites from marine sponges and sponge-derived fungi
… medicinals and agrochemicals. In the search for bioactive compounds from marine sponges and sponge-associated fungi, this research work resulted to the isolation of twenty-six compounds, eight of which are new metabolites. The sponges were collected from the Indo-pacific regions, particularly …
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Marine microbial co-cultivation and the production of novel bioactive secondary metabolites for drug discovery
… to probe the depths of the oceans for new secondary metabolites. In a project led by the University of Strathclyde in conjunction with the EU funded project Seabiotech, a metabolomic-based approach to drug discovery was utilised, to analyse and scale up the production of bioactive …
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A metabolomics approach for targeted isolation and production of bioactive secondary metabolites in microbial isolates from extreme environments
Marine microorganisms produce unique secondary metabolites, which are responsible for a variety of biologically active molecules with a wide range of pharmaceutical properties. There is a lack of novel effective drugs for metabolic diseases, cancer and parasite infections as well as TNF-alpha …
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High Resolution Mass Spectrometry (HRMS) Based Investigation of Small Molecule, Bioactive Secondary Metabolites as Probes in the Examination of Bacterial Resistance and Virulence
<p>The widespread availability of antimicrobial chemotherapeutics over the last half of the twentieth century has offered dramatic increases in life expectancy. Unfortunately, many pathogenic agents are exhibiting ever increasing resistance to many frontline antibiotics. New chemotherapeutic agents …
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Ecology and Synthetic Biology as Tools for Natural Products Discovery From Marine Proteobacteria
… bacteria are prolific producers of fascinating bioactive secondary metabolites with structures and bioactivities that have recently attracted a lot of attention as leads for new pharmaceutical scaffolds. With recent advances in genomic sequencing, genomic analysis, and genetic engineering, it …
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A multilocus phylogeny of Hericium fungi in Canada and their production of Erinacine A
… contains species demonstrated to produce bioactive secondary metabolites with potential medical applications. Previous phylogenies of the genus Hericium based on the internal transcribed spacer (ITS) region struggle to support monophyly at the species level, hindering biochemical research …
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An ethnobotanical, phytochemical and metabolomics investigstion of plants from the Paulshoek Communal Area, Namaqualand
… and streamlined method for the discovery of bioactive secondary metabolites of plant origin. This will be done through a focused study of the traditionally used medicinal plants of the Paulshoek region of Namaqualand and a demographic study of the people who use them. Trends in traditional …
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A molecular characterization of the fungal endophytes within the needles of ponderosa pine (Pinus ponderosa)
… conifers host endophytes that produce important bioactive secondary metabolites. While the endophytes in Pinus ponderosa roots have been studied, the endophyte communities within the needles are not well characterized by molecular means: thus, the goal of this study was to do so. Needles were …
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Isolation, Structure Elucidation and Biological Evaluation of Natural Products From Plants and Fungi
… products or inspired by natural compounds. Bioactive secondary metabolites isolated from natural source, either fungal or terrestrial, are relatively safer for human health and the environment and can serve as drug or as drug leads for the development of synthetic or semi-synthetic analogs. …
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Natural Product Biosynthesis In Uncultured Bacteria
… microorganisms has provided access to numerous bioactive secondary metabolites, with these same methods it is not possible to characterize the natural products encoded by the uncultured majority. The heterologous expression of biosynthetic gene clusters cloned from DNA extracted directly from …
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Functional and mathematical analysis of the glyoxylate shunt in Streptomyces coelicolor
… for the genus Streptomyces, which produces many bioactive secondary metabolites with clinical applications. Based on work done in Escherichia coli, the glyoxylate shunt was thought to be the main anapleurotic pathway in S. coelicolor during growth on fatty acids and therefore an important pathway …
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Novel regulators of antibiotic biosynthesis in Serratia sp. ATCC 39006
… studies on the biosynthesis and regulation of bioactive secondary metabolites, particularly two antibiotics – prodigiosin and a carbapenem. Both compounds are tightly regulated in response to various physiological and environmental signals, including quorum sensing. This project aimed to …
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Antimicrobial activities and diversity of sponge derived microbes
… obtained from 12 sponge samples proved to be bioactive. One of the isolates, which was closely related to Fusarium oxysporum and showed activity against bacteria and fungi, was investigated for its secondary metabolite genes. At least 5 different NRPS genes, with a sequence similarity as low …
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Functional Studies of Novel Bioactives From Complex Host-Microbiomes as Drug Leads for Cancer, Infectious Disease, Depression and Pain
… the rate of isolating and elucidating new bioactive secondary metabolites. A cystine-rich peptide asteropusin A (ASPA) was isolated from the marine sponge Asteropus sp. and its structure determined by X-ray crystallography and NMR spectroscopy. Administration of ASPA to …