Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"Bioactive peptides"”.
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Discovery of bioactive peptides from amphibian skin secretion
… their unique defence mechanisms. Among these, bioactive peptides in special skin secretions produced by frogs have been considered to be one of the rich natural sources for developing new drugs in the future.<br/><br/>In this thesis, several bioactive peptides were identified from the skin …
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Bioactive Peptides as Antibacterial Agents and Visual Transduction
Bioactive peptides (BPs) are specific protein fragments which positively impact bodily functions and primary health conditions. BPs are formed from amino acids linked by amide bonds and classified by their mode of action in health-related applications. The amino acid composition and their secondary …
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Nutraceutical and functional food bioactive peptides in beef
… approaches has received considerable attention. Bioactive peptides which are released during the hydrolysis or fermentation of food proteins or following digestion may exert beneficial physiological effects in vivo. The aim of this work was to isolate, characterise and evaluate …
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CHARACTERIZATION OF BIOACTIVE PEPTIDES IDENTIFIED FROM GENETICALLY ENCODED LIBRARIES.
… insurgence. In this scenario, antimicrobial peptides (AMPs) can represent a solution as they show specificity, efficacy and rapid degradation, thus avoiding the long-term effects observed for chemical pesticides. During the last years, some AMPs have been successfully commercialized as plant …
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Bioactive peptides from the skin secretion of Kassina senegalensis
Bioactive peptides in amphibian skin have been reported to have various pharmacological activities. The discoveries of these peptides have become hot spots in the development of new drugs.<br/><br/>In Chapter 3, peptides QUB-1641, QUB-1746, Kassinakinin S and Senegalin were isolated from Kassina …
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Release of bioactive peptides from milk proteins by lactobacillus species
… by liberating a number of biologically active peptides. The main aim of this project was to determine the release of bioactive peptides from milk proteins by selected Lactobacillus species.
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Identification, characterisation and design of bioactive peptides from Chinese frogs
Antimicrobial peptides from amphibian skin secretions have become candidates as replacements for conventional antibiotic therapies. Temporin is an AMP type found in skin secretions of frogs from the family Ranidae, In Chapter 3, a novel temporin family peptide, QUB1434, was identified from …
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Functional genomic study and bioinformatic analysis on natural bioactive peptides
… multiple chemical compounds, among which, peptides are one of the major types of the constituents.This thesis is divided into six chapters. Chapter 1, as general introduction, describes the detailed background on peptide-based therapeutic agents, the promising therapeutic application of …
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Starch based systems for the colonic delivery of bioactive peptides
Bioactive peptides have numerous health benefits, although if taken orally they may be digested during gastrointestinal (GI) transit. Encapsulation is an established method for oral delivery of bioactives. However, many current approaches arise from pharmaceutical applications and may be unsuitable …
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A biosynthetic approach to the discovery of novel bioactive peptides
Peptides represent a source of novel therapeutics for recalcitrant human diseases, but screening for bioactivity from natural or synthetic sources can be uneconomic. In contrast, in vivo expression of peptides from DNA libraries in a heterologous host such as Escherichia coli may combine production …
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Discovery and design of novel bioactive peptides from amphibian skin secretion
… to obtain the sequences of natural antimicrobial peptides and their synthesis was achieved using solid-phase synthesis (SPPS). In addition, the peptides were purified and identified by high-performance liquid chromatography (HPLC) and MALDI-TOF MS, and their biological activity was …
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Novel bioactive peptides from the defensive skin secretion of Phyllomedusinae frogs
… contains a variety of bio-components, of which bioactive peptides are predominant. They produce such peptides to protect themselves from the threats in their environment like predatory attack and microorganism invasion. Antimicrobial peptides (AMPs) act as the first line of self-defence and …
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Discovery, structural characterisation and targeted engineering of bioactive peptides from amphibian skin secretion
… skin secretions are remarkable sources of novel bioactive peptides. Among these, the antimicrobial peptides (AMPs) have demonstrated an outstanding efficacy in killing microorganisms via a general membranolytic mechanism, which may offer a prospect of solving specific target driven …
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Bioactive peptides from the defensive skin secretions of selected American and Asian frogs
… biochemical/pharmaceutical components including peptides, proteins and nucleic acids, derived from amphibians, have been subjected to intensive studies. Original research work on these bioactive substances such as bradykinin-related peptides and antimicrobial peptides, indicates that they have …
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Molecular cloning, structural characterisation and functional study of bioactive peptides from amphibian skin secretion
… chemicals, including alkaloids, proteins and peptides. In recent years, research on peptides from the skin secretion of frogs has attracted much attention in the fields of protease inhibitor peptides and antimicrobial peptides. In this study, the skin secretion of two frogs, Amolops …
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Discovery and design of novel bioactive peptides from the skin secretion of Ranidae frogs
… helped here in the study of five novel peptides. In Chapter 3, a novel potent antimicrobial peptide QUB 2282 was found in the skin secretion of the Fujian Large-headed Frog (Limnonectes fujianensis), displaying differential growth-inhibiting activity on different microorganisms, even …
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Endothelial cell response to bioactive peptides and stiffened extracellular matrices: an investigation into atherogenic pathways
… (NO) which can be upregulated in the presence of bioactive milk peptides. An investigation into the NO liberating capacity of select bioactive peptides was performed on cultures of Human Umbilical Vein Endothelial Cells (HUVECs) and two tripeptides (VPP and IPP) were found to liberate ~50% more …
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Identification and evaluation of bioactive peptides from amphibian skin and rational design of new analogues
… remarkable antimicrobial capacity, antimicrobial peptides are at the forefront of new antibacterial drugs. In our research, we are working with the isolation and identification of small molecule peptides with potent bioactivity from frog skin secretions and performing functional experiments on …
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Identification, molecular cloning and modification of skin-derived bioactive peptides from selected Hylidae and Ranidae
… One of the greatest adaptations was the peptides secreted from the skin, which are of great importance to maintain their everyday life. Diverse bioactivities and potential pharmaceutical functions of peptides have been confirmed by researchers in recent years. Many peptides show …
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