Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Bioactive natural products"”.
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Discovery and Delivery of Bioactive Natural Products
As a part of search for bioactive natural products from the plants in collaboration with the Natural Products Discovery Institute (NPDI), ten plant extracts were investigated for their antiplasmodial activity against Plasmodium falciparum Dd2 strain. Twenty-eight compounds were isolated, and twelve …
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Structural and synthetic studies of bioactive natural products
… cujete resulted in the isolation of nine bioactive compounds, and detailed spectroscopic interpretation led to the assignment of their structures as (2S,3S)-3-hydroxy-5,6-dimethoxy dehydroiso-α-Iapachone [2.10], (2R)-5,6- dimethoxydehydroiso-α-Iapachone [2.11], (2R)-5-methoxy …
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Structural and Synthetic Studies of Bioactive Natural Products
… ongoing investigation for anticancer agents from natural resources, four plant extracts were determined to contain interesting bioactivity. These extracts were separated by chromatography to afford a number of bioactive compounds that were characterized by spectral analysis. Fractionation of the …
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Studies of Bioactive Natural Products and Mechanism-Based Bioassays
… were prepared semisynthetically from the natural product, tested for their bioactivity, and their structure-activity dependence was observed. Bioassay guided-fractionation of an extract of a <i>Tuemoya</i> sp. green alga, using an assay for inhibitors of the enzyme Tie2 kinase, afforded a …
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Total synthesis of bioactive natural products: Darobactin A and nimbolide
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Isolation, Characterization, and Synthesis of Bioactive Natural Products from Rainforest Flora
… separation techniques, affording a number of bioactive compounds that were then characterized by spectral and degradative methods. A methanol extract of Cestrum latifolium Lam. yielded the known compound parissaponin Pb. Hydrolysis afforded its aglycone, the known spirostanol diosgenin. GCMS …
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The development of dearomative functionalizations and their use in the total synthesis of bioactive natural products
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Neue chirale Triazoliumsalze in der Carben-katalysierten intramolekularen gekreuzten Benzoin-Reaktion
… are structural motifs of many bioactive natural products. Thus, synthetic concepts for the synthesis of (S)-eucomol and (S)-lacinilen C methylether have been followed. Furthermore, an efficient proline-catalyzed asymmetric intramolecular 5-enolexo aldol reaction for the …
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Synthesis of Deoxysugars through Manganese-promoted Redox Isomerization
Deoxysugars feature prominently in many bioactive natural products and pharmaceutical compounds. Many synthetic routes towards deoxysugars rely on protecting groups to achieve selective outcomes. Here we report a concise synthetic strategy to access a diverse set of 2- and 4-deoxysugars using a …
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Phosphate Tether-Mediated, One-Pot Metathesis Processes: Application in Small Molecule Synthesis
… a series of reactions towards the synthesis of bioactive molecules by exploiting several salient features inherent to organophosphates, including (i) orthogonal stability under acid conditions, (ii) possessing leaving group ability, (iii) multivalent activation of carbinol centers, (iv) …
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Investigation of the Discoipyrroles and Other Marine Bacteria Derived Natural Products
Natural products are a rich source of scientific innovation. These chemical compounds are canonically celebrated as biomedical tools or synthetic chemistry feats. Discovery of new chemical compounds has benefited from the study of natural product biosynthesis, or the methods by which they are …
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Synthesis of Sulfonyl Fluorides and the Total Synthesis of the Rhodocorane Natural Products
… reactivity are the key to the synthesis of many bioactive and structurally challenging molecules, synthetic methodologies to install and understand these reactive moieties is always of interest to organic chemists. However, there is a fine line between too reactive and not reactive enough. Our …
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Isolation and Structure Elucidation of Antiproliferative Natural Products from Madagascar
As part of an ongoing search for bioactive natural products from the endemic rainforests and surrounding ocean in Madagascar, a total of four extracts were comprehensively studied and were found to contain novel and/or bioactive compounds. The following dissertation discusses the isolation, …
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Isolation, Synthesis and Structure-Activity Relationship Study of Anticancer and Antimalarial Agents from Natural Products
… Research (IHVR) has focused on the search for bioactive natural products from tropical forests in both Madagascar and South Africa. As a part of this research, a total of four antiproliferative extracts were studied, leading to the isolation of fourteen novel compounds with antiproliferative …
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Asymmetric Synthesis of 1,3-Amino Alcohols and Tropinone Derivatives From Enantiopure Sulfinimines
… pyrrolidine and tropane, are widespread as natural product alkaloids and serve as templates for many bioactive drugs and drug candidates. The intent of this research is to the develop asymmetric syntheses of piperidine-containing syn and anti 1,3-amino alcohols as well as tropinone and …
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A novel photocatalytic strategy for complex aliphatic amine synthesis and the total synthesis of alkaloids (−) FR901483 and (+)-TAN1251C
… furnishes complex aliphatic tertiary amine products. Selective generation of an $\alpha$-amino radical species is achieved via photocatalytic single electron reduction of in situ generated all-alkyl iminium ions. Under optimized reaction conditions, the photocatalytic …
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Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products
… and a continuing search for antiproliferative natural products from the Madagascar rainforest, and a collaborative research project established between Virginia Tech and the Institute for Hepatitis and Virus Research (IHVR) focusing on searching for bioactive natural products from tropical …
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Understanding and manipulating alkaloid biosynthesis
… of metabolic pathways that produces hundreds of bioactive natural products, has not been fully elucidated in any organism. Here we examine the biosynthesis of secologanin, which contributes the monoterpene moiety to all MIAs. Specifically, we excavate C. roseus transcriptomic datasets to identify …
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TEMPLATE DIRECTED C-H INSERTION REACTIONS FOR STEREOCONTROLLED SYNTHESIS OF HETEROCYCLES
… analogues are abundant in a large variety of bioactive natural products and continue to play crucial roles in modern day chemotherapy. The bioactivities of these heterocycles are highly dependent on the stereochemistry of the substituents and therefore the development of elegant new …
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