Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Bioactive molecules"”.
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Nanostructures for protection and vehiculation of bioactive molecules
… proteins and nucleic acids, are essential biomolecules for the structure and function of living matter. Most lipids are fats and waxes, but many others have unique structural features due to their amphiphilic character. The choice of polar lipid based systems to build nanostructured …
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Opto-Electronic Modulation of Quantum Dots by Cells and Bioactive Molecules
… a paucity of work on how biological systems and bioactive molecules might be used to alter the opto-electronic properties of QDs.|Here, we show that these properties can be altered by bioactive molecules and biological macromolecules following controlled changes in cellular activities. Using …
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Supramolecular derivatisation of bioactive molecules via co-crystallization and cyclodextrin inclusion complexation
The objective of this study was to modify the physicochemical properties of two common drugs via supramolecular derivatization. Sulfasalazine is a powerful anti-inflammatory drug and fluconazole has a strong antibacterial and antifungal activity. The common feature is their very low solubility in …
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… pathophysiological processes through the use of molecules that become bioactive upon light stimulation. Initially applied mainly to biological investigations, optopharmacology is now increasingly recognized for its great potential in the clinical and medical fields. Among the various …
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NOVEL SUSTAINABLE STRATEGIES FOR THE SYNTHESIS OF ACTIVE PHARMACEUTICAL INGREDIENTS (APIS) AND BIOACTIVE MOLECULES THROUGH THE EXPLOITATION OF ISOLATED ENZYMES AS BIOCATALYSTS
… greener and more efficient synthesis of complex molecules. Biocatalyzed reactions can be performed by exploiting either purified isolated enzymes or lyophilized crude cell lysates. The wide availability of commercial synthetic genes suggests that, at least theoretically, any enzyme with a known …
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Design, synthesis, and evaluation of bioactive molecules; Chiral polyvinylpyrrolidones supported Cu/Au nanoclusters catalyzed cyclization of 5-substituted nona-1,8-dien-5-ols
Small molecules are of great importance in drug discovery currently. The first three chapters discussed the design, synthesis and bio-evaluation of three different classes of small molecules and exploration of their biological targets. Triacsin C analogs were designed as long chain fatty acyl-CoA …
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Application of nanotechnologies for the therapeutic use of natural compounds
Natural compounds represent a valuable source of bioactive molecules with vast pharmacological potential; however, despite their therapeutic potential, the clinical application of natural extracts is often influenced by physicochemical and pharmacokinetic limitations, such as poor water solubility, …
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Imaging of Heterogeneous Langmuir -Blodgett Monolayer with Compressive Sensing Sum Frequency Generation Microscopy and Brewster Angle Microscopy
… interactions between phosphatidylcholines and bioactive molecules is the ability to chemically study surface heterogeneity. Langmuir Blodgett (LB) monolayers are widely used as standard models for cell membranes.
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Light-triggered release of bioactive compounds from HA/PLL multilayer films for stimulation of cells
… cells and tissues by controlled delivery of molecules is essential in the field of biomedicine. The layer-by-layer (LbL) technology for the fabrication of polymer multilayer films is widely implemented as a powerful tool to assemble tailor-made materials for controlled drug delivery. The LbL …
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Structure-based approaches applied to the study of pharmaceutical relevant targets
… speed up the detection and the optimization of bioactive molecules. The present study is focused on the application of structure-based approaches to the study of pharmaceutical relevant targets. The introduction provides a quick overview on the fundamentals of computational chemistry and …
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Modulation of cell morphology and function using synthetic biodegradable polymers
… for controlled and sustained delivery of bioactive molecules. Transforming growth factor-beta1 (TGF-beta1) was incorporated into microparticles of, blends of PLGA and poly(ethylene glycol) (PEG) as a model growth factor and released in vitro in buffer solutions simulating body fluids for …
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Manganese-catalyzed intermolecular benzylic C–H amination
… install nitrogen into C—H bonds of complex molecules are significant due to their ability to immediately change the chemical and biological properties of a given molecule. While selective intramolecular C—H amination reactions are known, intermolecular C—H amination reactions with high …
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Identification of potential antibiofilm hit compounds from two African natural product database against multi-drug resistant staphylococcus aureus: an in silico study
… of natural compounds makes them a reservoir of bioactive molecules for drug discovery. This study seeks to identify effective potential antibiofilm compounds from a query dataset compiled from two African natural product databases (SANCDb and AfroDb). A database of known antibiofilm compounds …
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Photochemical harpoons: covalent labels for multi-protein complexes
… the biomolecular interaction partners of small bioactive molecules is a fundamental problem in drug discovery and cell biology. This thesis describes the development of fluorescent chemical probes to identify the biomolecular targets of the known organophosphate toxin, phenyl saligenin phosphate …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… proteins, but also can process a number of bioactive molecules, and to perform key functions in tumor progression, and in other diseases. In this study, we report that TIS21 can decrease the expression at both mRNA and protein levels of MMPs in human breast cancer (MDA-MB-231) cells and …
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Direct ⍺-C–H Functionalisation of Cyclic Alkylamines
… to the late-stage modification of complex bioactive molecules, underscoring the potential of this methodology to expand drug-like chemical space.
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Copper-catalyzed enantioselective stereodivergent synthesis of amino alcohols
Different stereoisomers of bioactive molecules can have distinct activities in biological systems. For this reason, it is routine procedure in the drug discovery and development process to prepare the full matrix of possible stereoisomers of drug candidates for biological evaluation and to …
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Investigation of Cancer Stem Cells (CSCs)-derived exosomes and their influence on the tumor microenvironment
… microRNAs. In summary, CSC-derived exosomes are bioactive molecules mediating the interchange of informations and are able to stimulate target cells in order to develop tumor capacities. This function can be enhanced by the presence of CD133, which positively regulates the transport of bioactive …
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