Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Bioactive lipid mediators"”.
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ROLE OF 12/15 LIPOXYGENASE EXPRESSION IN LIPID METABOLISM, ATHEROSCLEROSIS AND INSULIN RESISTANCE
… fatty acids (PUFAs), forming a series of bioactive lipid mediators. Though lipid mediators produced by 12/15LO have the potential to affect lipid metabolism and atherosclerosis, the role of 12/15LO expression in these processes has not been elucidated.
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Studies on Bioactive Lipid Mediators Involved in Brain Function and Neurodegenerative Disorders. The effect of ¿-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation; changes in oxysterol profiles in blood of ALS patients and animal models of ALS.
Lipids are important for structural and physiological functions of neuronal cell membranes. They exhibit a range of biological effects many are bioactive lipid mediators derived from polyunsaturated fatty acids such as sphingolipids, fatty acid ethanolamides (FA-EA) and endocannabinoids (EC). These …
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The effect of eicosapentaenoic acid on brain and platelet produced bioactive lipid mediators. The effect of eicosapentaenoic acid, docosapentaenoic acid and other polyunsaturated fatty acids on the eicosanoids and endocannabinoids produced by rat brain and human platelets using electrospray ionisation tandem mass spectrometry-based analysis.
… acid (DHA) and arachidonic acid (AA) are bioactive PUFA ubiquitously expressed in neural tissues. EPA and AA can be converted by cyclooxygenase (COX) to prostanoids and by lipoxygenase (LOX) to hydroxy fatty acids. PUFA can also be converted to ethanolamides in the brain. These mediators …
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Mechanisms of inflammation resolution in a murine model of Lyme arthritis
… Our primary interest is the role of bioactive lipid mediators in mLA inflammation. Here we showed that 12/15-LO activity is required for efficient mLA resolution and that LXA4 may therapeutically ameliorate mLA by reducing edema and remodeling joint macrophage populations. We …
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FATTY ACIDS IN PHYSIOLOGY AND PATHOLOGY: FOCUS ON ALPHA-LINOLENIC ACID (ALA) AND PUFAS
… regulation, as well as serving as precursors to bioactive lipid mediators such as eicosanoids and prostaglandins. Following a general overview of fatty acid classification, structure, metabolism, and biochemistry, the thesis explores the relevance of ALA and LA in emerging clinical domains …