Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"BioMEMS"”.
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Surrogate-based optimization of a BioMEMs microfluidic weir
BioMEM microfluidic weirs enable biologists to study biological processes at the cell level. A novel substrate-affixed microfluidic array of weirs allows active sorting of cells via control electrodes. The ability of the weirs to retain cells hydrodynamically is vital to the functionality of the …
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Polyelectrolyte multilayers (PEM) in micro / nanofluidics for novel BioMEMS platforms
… device for patterning bacteria in BioMEMS. Nanofluidic channels offer new opportunities for advanced biomolecule manipulation and separation science because they provide unique capabilities such as ion-perm selectivity and nanometer-sized structures. In order to establish industrial …
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MICROFABRICATION OF TITANIUM DIBORIDE PATTERNED ON SILICON SUBSTRATES FOR MONO- AND CO-CULTURE OF ENDOTHELIAL AND MESENCHYMAL STEM CELLS
… their in vitro prolonged viability. Our designed BIOMEMS device evaluates the influence of substrate material properties such as mechanical, chemical and electrical using 2D sheet based configurations. The device has matrices of different geometries, to determine factors that affect cell growth …
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Surface Acoustic Wave-Actuated Cell Sorting and Enantiomer Separation
… by a biomedical micro-electro-mechanical system (BioMEMS) whose operating principle depends on surface acoustic wave (SAW)-manipulated fluid flow in a microchannel. The BioMEMS consists of a separation channel with three inflow channels for injection of the carrier fluid and the cells, two outflow …
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Software systems for a DNA sequencer
… capabilities to the forefront. We at the BioMEMS engineering group at the Whitehead Institute are designing and building a new sequencing machine that uses a 384 glass "chip" to dramatically increase sequencing rates. This thesis describes the design and implementation of two of the …
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An ultra-high throughput mutational spectrometer for human genetic diagnostics
… control. To manipulate DNA, we have utilized a bioMEMS design platform for interfacing to an array of separation channels that enables electrokinetic biomolecule loading, detection, and fraction collection in independent wells.
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Rapid Prototyping Of Microfluidic Packages
… need to evolve some standardization. In BioMEMS devices the packaging issue is concerned with delivering a sample to the device, conducting the sample to the sensor or sensors, and removing the sample. Conducting the sample to the sensor or sensors is usually done with microchannels …
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Microfluidic Selection and Applications of Aptamers
BioMEMS technology has the potential to increase the efficiency of conventional biological and medical protocols, by reducing their consumption of time and resources. Through more efficient surface-based chemical reactions and automation of tedious manual processes, orders of magnitude increases in …
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Identification of Cell Biomechanical Signatures Using Three Dimensional Isotropic Microstructures
… Integration of MEMS technology and biology (BioMEMS) enables precise control of the cellular microenvironments and offers high throughput systems. The focus of this research was to develop three dimensional (3-D) isotropic microstructures for comprehensive analysis on cell-substrate …
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Computational electrohydrodynamics for fabricating polymer microstructures
… the biomedical sector as microstructures used in BioMEMS. Further development of the process is required to ensure that the process can be controlled. The models presented here are initial investigations of this but further experimental work is required along with the expansion of the model into …
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Point-of-care microfluidic assays for measuring expression level of antigen on blood cells
Elevated expression of a membrane protein CD64 on neutrophils is linked with the onset of sepsis, a life-threatening syndrome that contributes to millions of deaths annually worldwide. The survival rate of septic patients falls rapidly every hour the appropriate medication is delayed. Therefore, …
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Physics and Applications of a PDMS Based Centrifugal Microfluidic System
The objective of this research work is to develop a centrifugal microfluidic system for general purposes based on microfabrication technologies including SU-8 photolithography, polydimethylsiloxane (PDMS) casting. The main contribution of this research is to integrate a flyball governor system into …
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Design, Fabrication, and Implementation of a Single-Cell Capture Chamber for a Microfluidic Impedance Sensor
A microfluidic device was created for single-cell capture and analysis using polydimethylsiloxane (PDMS) channels and a glass substrate to develop a microfluidic single-cell impedance sensor for cell diagnostics. The device was fabricated using photolithography to create a master mold which in turn …
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Two-Dimensional and High-Throughput Electrophoretic Separation of Proteins Using Polymeric Microchips
A major task in proteomics is to identify proteins from a biological sample using two-dimensional (2-D) separation prior to mass spectrometry of peptides generated via proteolytic digestion of the proteins. For 2-D separations, microfluidic devices are superior to bench top and capillary-based …
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Selective Isolation of Circulating Tumor Cells in Antibody-Functionalized Microsystems
Attachment of circulating tumor cells in microfluidic devices functionalized with proper antibodies was studied. Under static experimental conditions, microchambers were utilized to study the parameters such as cell suspension concentration, incubation time or ambient temperature that may affect …
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MEMS Piezoresistive Micro-Cantilever Arrays for Sensing Applications
… on two different technologies developed at the BioMEMS research unit of FBK (Fondazione Bruno Kessler - Center for Materials and Microsystems, Trento). The first process, based on wet-etching bulk micromachining techniques, has provided 10 Âμm-thick silicon microcantilevers while the second …