Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Bio-conjugation"”.
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New methods for synthesis and modification of peptides and proteins
… of tools for tailoring the properties of these biomolecules to specific applications. A number of bio-conjugation reactions allows fine-tuning of the biological activity, proteolytic stability, and immunogenicity of peptides and proteins, as well as equipping them with completely novel functions …
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Digital Profiling of Circulating Extracellular Vesicles at Single-Upconversion Nanoparticle Sensitivity and Resolution
… of single EVs, particularly from liquid biopsy sampling, will guide clinical decisions on the stages of tumour progression. However, the nanoscopic sizes (typically 40-200 nm) and the extremely small quantity of cargo materials demand the high detection sensitivity, stability, resolution …
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Targeting GRP78 in Cancer with Nucleic Acid Bioconjugates
<p>Nucleic acid bioconjugates have gained widespread use in medicinal chemistry research programs aimed at fighting human malignancies such as cancer, diabetes, genetic and infectious diseases. Their popularity stems from their ability to accelerate the drug development process by conjugating …
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Single-Molecule Characterization of Photophysical and Colloidal Properties of Biocompatible Quantum Dots
… as novel fluorescent labels for various biological applications. Their unique optical properties — tunable narrow emission spectrum, broad excitation spectrum, high photostability and long fluorescent lifetimes (on the order of tens of nanoseconds) — make them attractive probes in …
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Deoxyribozymes to hydrolyze DNA phosphodiester bonds
… the requirement of a site-specific and efficient bio-conjugation method to link the deoxyribozyme pool with the TALE protein. Four conjugation strategies were designed, based on disulfide exchange reaction, FBDP-tyrosine reaction, PTAD-tyrosine reaction, or N-terminal threonine oxidation. After …
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Development of Au-Pt Nanoflowers as Nanoenzyme for Highly Sensitive Immunoassay: Application to the Detection of Melioidosis Biomarker
… have become widely used for detecting biomarkers in clinical and research settings. Nanoparticles with enzyme-mimic properties, known as nanozymes, have garnered significant attention for their potential in revolutionizing immuno-sensing due to their tunable catalytic activity, …