Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Binding specificity and affinity"”.
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Engineering and targeting glycan receptor binding of influenza A virus hemagglutinin
… the host infection by influenza A virus is the binding of the viral surface glycoprotein hemagglutinin (HA) to the sialylated glycan receptors terminated by N-acetyineuraminic acid (Neu5Ac) expressed on the host cell surface. Glycans terminating in Neu5Ac that is a2-6 and a2-3 linked to the …
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Human adaptation of avian influenza viruses
… are strains belonging to H5N1, H7N7, H7N2 and H9N2 subtypes that continue to circulate in birds worldwide and have on occasions caused infections in humans. A key step in influenza human adaptation is the accumulation of substitutions/mutations in the viral coat glycoprotein, hemagglutinin …
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Glycan receptor binding determinants of Influenza A virus hemagglutinin
An understanding of the factors involved in the human adaptation of influenza A viruses is critical for various aspects of influenza preparedness, including the development of appropriate surveillance measures, preventive strategies and effective treatments. A key step in influenza human adaptation …
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Rational design, characterization and in vivo studies of antibody mimics against HER2
… is a cell surface receptor tyrosine kinase and plays a role in the signal pathways leading to cell proliferation and differentiation. Overexpression of HER2 is found in various cancers including breast, ovarian, gastric, colon, and non-small-cell lung cancers, which makes it an attractive …