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Showing 1 to 20 of 916 for “"Binding sites"”.
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Functional and developmental characterisation of matrix binding sites in decapentaplegic
… which has been shown to contain a heparin-binding site in BMP-2. Thus, a wildtype variant (D-MYC), a deletion variant (D-DEL), which lacked the whole basic part of the N-terminus and a duplication variant (D-DUP), which contained a second copy of the basic core moitiv, were generated. In …
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Studies of the metal-binding sites in macrocyclic quadridentate ligands
The preparations of quadridentate macrocyclic ligands with N4-, O2N2- and S2N2-donor-sets are described.
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Mapping Ligand Binding Sites in hERG1 Channel with Biomolecular Simulations
… approaches for mapping of potential drug binding sites in hERG1 and rapid assessment of drug blockade. In this thesis, first, we used free energy sampling methods to establish a connection between the cryo-EM structure of the hERG1 channel and its functionality. Furthermore, using the …
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Detection and analysis of binding sites and protein-ligand interactions
Detection and analysis of protein-ligand binding sites is an important area of research in drug discovery. The FTMap web server is an established computational method for detection of binding hot spots, or regions on the protein surface that contribute disproportionately to the ligand binding free …
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Investigating The Metal Binding Sites In Znta, A Zinc Transporting Atpase
… ions out of the cytoplasm. ZntA has two metal binding sites, one in the hydrophilic N-terminal domain and the other in the transmembrane region. The cysteine-rich N-terminal domain has ~110 amino acids and the conserved motifs -CCCDXXC- and -DCXXC-. The role of these motifs in metal-binding …
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Discovery of Alternative Artemisinin Binding Sites in Plasmodium falciparum ATPase-6
… of an infected Anopheles mosquito. Malaria parasites belong to the Plasmodium genus and can be caused by the falciparum, malariae, ovale, vivax, and knowlesi species. Artemisinin is an endoperoxide lactone extracted from qinghaosu (Artemisia annua L. or sweet wormwood). It and its derivatives …
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Preparation of arylphosphinic acid derivatives as building blocks for binding sites
<p>Several members of a new class of potential binding sites have been designed and prepared from a novel bis amino acid, bisphenylalanylphosphinic acid. The synthesis starts by making 4-iodophenylalanine, for which a greatly improved preparation has been developed. With this method, multi-gram …
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Binding sites in the nuclear envelope for cytoplasmic glucocorticoid receptor complex
… purified rat liver nuclei were found to contain binding sites for the partially purified cytoplasmic triamcinolone acetonide-receptor complex. The binding constants showed two saturable high affinity binding sites and the envelope bound the complex with a specific activity ten times higher than …
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Predicting enhancer regions and transcription factor binding sites in D. melanogaster
… and D. melanogaster genomes. The genome- wide binding locations of all known transcription factors as well as of other DNA- binding proteins are currently being mapped within the context of this project [8]. The large quantity of new data that is becoming available through the modENCODE project …
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Thermodynamics of λ-PCR Primer Design and Effective Ribosome Binding Sites
… reactions. Additionally, synthetic ribosome binding sites (RBS) were included in the primer designs to test heterologous protein expression of the cyan fluorescent reporter with different RBS strengths. These RBS sequences were designed with an online tool, the RBS Calculator. A chimeric …
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Integrating Epigenetic Priors For Improving Computational Identification of Transcription Factor Binding Sites
… in tissue-specific gene expression. Identifying binding sites is key in understanding the regulatory interactions of gene expression. Nave computational approaches uses solely DNA sequence data to construct models known as Position Weight Matrices. However, the various assumptions and the lack of …
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Lbpi: A Web Interface For The Identification of Allosteric Ligand Binding Sites
… of efficient tools for allosteric ligand binding site identification in potential drug targets is an important step for computational drug design. Ligand binding specificity analysis (LIBSA) is one of the protocols that utilize filtering algorithms to assess the propensity of a site on a …
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Lbpi: A Web Interface For The Identification of Allosteric Ligand Binding Sites
… of efficient tools for allosteric ligand binding site identification in potential drug targets is an important step for computational drug design. Ligand binding specificity analysis (LIBSA) is one of the protocols that utilizes filtering algorithms to assess the propensity of a site on a …
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A robust machine learning approach for the prediction of allosteric binding sites
Allosteric regulatory sites are highly prized targets in drug discovery. They remain difficult to detect by conventional methods, with the vast majority of known examples being found serendipitously. Herein, a rigorous, wholly-computational protocol is presented for the prediction of allosteric …
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Identifying potential binding sites of Nectin 4 for bespoke anti-cancer peptides
… design, size and excretion pathway. The precise binding sites of bicycle peptides to Nectin 4 are currently unknown. The initial aim of this project was to produce Nectin 4 constructs, conduct co-crystallisation with BDCs and perform x-ray crystallography studies, to elucidate the bicycle binding …
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The Mapping of Transcription Factor Binding Sites in the Turkey Prolactin Gene
… in vivo. The mapping of transcription factor binding sites in the tPRL 5'-flanking region is the first step toward the identification and isolation of factors that bind to and regulate transcription of the PRL gene.
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