Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 720 for “"Binding proteins"”.
-
Calling Cards For DNA-Binding Proteins
… I developed transposon "Calling Cards" for DNA-binding proteins. I endowed DNA binding proteins with the ability to direct the insertion of a transposon into the genome near to where they bind. The transposon becomes a "Calling Card" that marks the visit of a DNA-binding protein to the genome. I …
-
RNA-binding proteins in yeast mitochondria
… both of which have been identified as RNA-binding proteins without known RNA recognition motifs. Besides analysing their effects on mitochondrial translation and their organisation in protein complexes the work focused on the characterisation of the RNA-binding properties of recombinant …
-
Functional Evolution of Solute-Binding Proteins
Solute-binding proteins (SBPs) comprise an abundant and adaptable superfamily of extracytoplasmic solute receptors involved in nutrient uptake and chemotaxis, and constitute an important component of the nutrient-scavenging arsenal in bacteria. The SBP superfamily exemplifies the power of evolution …
-
Functional Evolution of Solute-Binding Proteins
Solute-binding proteins (SBPs) comprise an abundant and adaptable superfamily of extracytoplasmic solute receptors involved in nutrient uptake and chemotaxis, and constitute an important component of the nutrient-scavenging arsenal in bacteria. The SBP superfamily exemplifies the power of evolution …
-
The penicillin-binding proteins of Bacilli
A study of the penicillin-binding proteins (PBPs) in the membranes of various species of Bacilli by dodecylsulphate/polyacrylamide gel electrophoresis followed by detection of the PBPs by fluorography has shown the presence of 3-5 such proteins depending on the species. Labelling of growing cells …
-
Directed Evolution of Glycan-Binding Proteins
Glycan-binding proteins (GBPs) are commonly used reagents for the study of glycans. They do not require specialized equipment or time-consuming experimental methods, making them widely used tools for basic research and clinical applications. Existing glycan recognition reagents,antibodies and …
-
Small gtp-binding proteins in insulin secretion
… GSIS involves interplay between small G-proteins and their regulatory factors. Herein, I tested the hypothesis that Arf nucleotide binding site opener [ARNO], a guanine nucleotide exchange factor [GEF] for the small G-protein Arf6, mediates the activation of Arf6, and that ARNO/Arf6 …
-
Investigation of m6A-regulated RNA-binding proteins
… processes are mediated by a group of m6A RNA-binding proteins known as ‘readers’ that bind modified RNA - directly or indirectly - and recruit other protein complexes to alter RNA fate. Canonical m6A readers include the YTH family of proteins which directly interact with the modification in …
-
RNA binding proteins in neurotoxic protein clearance
… of damaged cellular components, misfolded proteins, and aggregates leads to the accumulation of neurotoxic proteins, and an increase in cellular stressors such as reactive oxygen species – eventually causing neuronal cell death. In the case of PD, neuronal inclusions are composed primarily …
-
Investigations on extra- and intracellular retinol-binding proteins
… and a ROH transport protein, the retinol-binding protein 4 (RBP4), in insulin resistance and type 2 diabetes. However, there is still considerable scientific debate about this relation. With the increasing amount of studies investigating the relation of ROH in obesity and type 2 diabetes, …
-
Understanding regulation of mRNA by RNA binding proteins
Posttranscriptional regulation of mRNA by RNA-binding proteins plays key roles in regulating the transcriptome over the course of development, between tissues and in disease states. The specific interactions between mRNA and protein are controlled by the proteins' inherent affinities for different …
-
Analysis of DNA-binding Proteins in Yeast Saccharomyces Cerevisiae
… involving the regulated interactions of multiple proteins with promoter and enhancer elements. A variety of approaches are currently used to study these interactions in vivo, in vitro as well as in silico. With the genome sequences of many organisms now readily available, a plethora of DNA …
-
Mechanical Manipulation of Eukaryotic Chromatin by DNA-Binding Proteins
… the dynamic interplay of Sox2 and H1 DNA binding activity. Both families constitute large classes of chromatin and DNA binding proteins that have been historically thought to be antagonistic regulators of each other, but the underlying mechanism is not well understood. Using …
-
Structural Studies of Two Sequence-General DNA -Binding Proteins
… than dsDNA-protein interactions. Gene V proteins from the filamentous phages are excellent systems for studying the interactions between protein and ssDNA. Some high resolution crystal structures were determined already. The abundant biophysical and biochemical data also afford us a rich …
-
Regulation of the spindle checkpoint by Mad2 binding proteins
… to the mitotic spindle. Spindle checkpoint proteins localize to unattached or maloriented kinetochores in mitosis and generate a signal that prevents dissolution of sister chromatid cohesion. Checkpoint signaling requires binding of Mad2 to the checkpoint protein Madl and Cdc20, a subunit of …
-
Biochemical and functional characterization of human RNA binding proteins
RNA not only shuttles information between DNA and proteins but also carries out many other essential cellular functions. Nearly all steps of an RNA's life cycle are controlled by approximately one thousand RNA binding proteins (RBPs) that direct RNA splicing, cleavage and polyadenylation, …
-
Designing Novel DNA-Binding Proteins with Generative Deep Learning
… protein backbones specifically tailored for DNA binding remains a challenging task, requiring the exploration of novel computational approaches. This thesis presents a novel framework for gen- erating protein backbones that exhibit affinity for DNA molecules. The proposed methodology leverages …
-
RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… we observed significantly increased poly-A-Binding protein (PABP) expression localizing to discrete punctate structures in both vascular smooth muscle (VSMC) and endothelial cells (EC) of the aortic arch of Ldlr-/- mice, as compared to WT controls. EIF2α phosphorylation, requisite for SG …
Page 1 of 36