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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Binding ligands"”.
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Identification and investigation of RNA-binding ligands
… chosen for their potential to act as RNA binding ligands. From the initial screen, I identified several promising lead compounds. I proceeded to perform a structure-activity relationship (SAR) study on one of the lead molecules, NSC657704. Based on the results of the SAR, I designed a set …
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Expression & Purification of Recombinant Plasmodium falciparum Erythrocyte-binding Ligands
… by Region II of the P. falciparum erythrocyte binding ligands. Although invasion does not seem dependent upon a singular ligand, their individual contributions to the invasion process are yet to be explained. In this study, Region II of P. falciparum binding ligands BAEBL and JESEBL were …
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Synthesis and biophysical evaluation of thiazole orange derivatives as DNA binding ligands
… - G-quadruplex, which is known to inhibit the binding of telomerase to telomeric regions in cancer cells and thus regulate unrestricted cancer cell growth. Hence, G-quadruplex DNA has recently become a promising target in oncology. The formation of G-quadruplex structures is greatly facilitated …
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Determination of Iron and Iron-Binding Ligands In Seawater With Flow Injection Analysis and Voltammetry
… organic ligand, and concentrations of total Fe-binding ligands ranged from 0.98 nM to 3.07 nM, with conditional stability constants ( ) ranging from 11.5 to 13.1. During the fall cruise, the highest concentrations of ligands were observed within 1 km to iceberg, presumably due to enhanced …
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Organic Copper Binding Ligands and Thiol Compounds Produced by Bacteria and in the Elizabeth River, Virginia
… work focusing on copper and organic copper binding ligands in laboratory cultures and the Elizabeth River, Virginia. Laboratory cultures of the marine bacterium <em>Vibrio parahaemolyticus </em>were used to demonstrate the influence of elevated copper concentrations on copper-complexing …
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Probing the roles of metal binding ligands in cupredoxins: incorporating nonproteinogenic amino acids into azurin and CuA Azurin
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-05-13T19:03:20Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Clark_Kevin.pdf: 14900477 bytes, checksum: 901cc6f1c2f90be4a62e58094e6f0b6d (MD5)
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Probing the Roles of Metal Binding Ligands in Cupredoxins: Incorporating Nonproteinogenic Amino Acids Into Azurin and Copper a Azurin
… in new insights into the role of the metal ligands and has shaped future metalloprotein engineering efforts.
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Microfluidics for Biomolecular Studies
… device. The sensor identified strongly binding ligands in a combinatorial screen of antibodies.
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SERS-active peptide nanoparticles for investigating protein allostery and bionanoassembly
… an allosteric assay for identifying novel binding ligands. SERS (Surface enhanced Raman scattering) - active nanoparticles, functionalized with a p53 peptide mimic, peptide 12.1, display biologically specific aggregation following addition of MDM2. The extent of nanoparticle assembly is …
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Rationalising the effect of guanine-based Ricin inhibitors using computer simulations
… inhibitors is the complete understanding of the binding pocket and the mode/nature of binding ligands to the protein. In this thesis computational methods were used to rationalise the effect of selected ricin inhibitors.
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Molecular determination of marine iron ligands by mass spectrometry
Marine microbes produce a wide variety of metal binding organic ligands that regulate the solubility and availability of biologically important metals such as iron, copper, cobalt, and zinc. In marine environments where the availability of iron limits microbial growth and carbon fixation rates, the …
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Method Development And Applications To Screening And Characterization Of Rrna-Targeting Small Molecules
… ring aminoglycoside analogues was tested for binding to a model RNA representing the A site using electrospray ionization mass spectrometry (ESI-MS). Several of the synthetic analogues with low molecular weights were found to bind to the RNA with affinities comparable to the parental …
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Molecular determination of marine iron ligands by mass spectrometry
Marine microbes produce a wide variety of metal binding organic ligands that regulate the solubility and availability of biologically important metals such as iron, copper, cobalt, and zinc. In marine environments where the availability of iron limits microbial growth and carbon fixation rates, the …
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I The synthesis and coordination chemistry of novel 1,1,1-tris(aminomethyl)ethane (TAME) derived ligands and their use as size selective fluorescent zinc(II) sensors II The synthesis of strongly and weakly binding ligands with nitrogen, oxygen, and sulfur-donor groups to be used as receptors in fluorescent ratiometric indicators for transition metal ions
… project was to synthesize strongly and weakly binding metal ion receptors to be copolymerized into the polyNIPA network. Fluorescent groups were also copolymerized into this network which acted as luminescent reporters upon analyte recognition. Depending on the charge of the bound …
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GLYCOSAMINOGLYCAN COATED GOLD NANOPARTICLES FOR TARGETED BREAST CANCER THERAPY
… and chondroitin sulfate A (CSA), are known as binding ligands of CD44 receptor and were used as non-toxic targeting ligands in targeted cancer therapy. Gold nanoparticles have been demonstrated to be highly useful for enhancing the delivery efficacy of a wide range of compounds. In this study, …
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Molecular actions of estrogen agonists and antagonists and their interaction with the human estrogen receptor
… the consequences of this interaction on the DNA binding and transactivating ability of the receptor. The functional role of cysteines in the hormone binding domain (HBD) of the receptor was examined by in vitro mutagenesis, followed by analysis of the hormone binding, covalent labeling and …
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Investigation of zinc metalloneurochemistry with fluorescent sensors based on fluorescein platforms
… physiological conditions corresponding to the binding of the Zn2+ cation to the sensor, which inhibits a photo-induced electron transfer (PET) quenching pathway. The X-ray crystal structure of a 2:1 Zn2/ZP1 complex has been solved. It is the first structurally characterized example of a complex …
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Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function
… HS PGs, are pivotal for the uptake of diverse HS binding ligands including polyamines and macromolecular antibody complexes. Finally, using a newly developed method for the isolation of endocytic vesicles, it is demonstrated that both classes of cell surface HS PGs, syndecans and glypicans, are …
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Computer-Aided Drug Design of G-quadruplex Structures: Harnessing Polarization for Rational Drug Design
… structural selectivity in current GQ-targeting ligands has limited their clinical success. This dissertation focuses on improving the rational design of GQ-binding ligands by advancing computational methods that better capture the structural and electrostatic properties of GQs. Central to this …
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