Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"Bilirubin"”.
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DNA Damage Induction by Bilirubin Induced Oxidative Stress and Activation of DNA Repair Pathways by Bilirubin
“Kernicterus” due to hyperbilirubinemia is one of main cause of irreversible brain damage in low and middle income countries. Deaths due to “kernicterus” are ranked within the top 3 causes of neonatal death in African countries. Neonates experiencing permanent or temporary absence or reduced …
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Correlation between transcutaneous bilirubin and total serum bilirubin levels among preterm neonates at Groote Schuur Hospital
Includes abstract. Includes bibliographical references.
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Bilirubin Nanoparticle As An Anti-Inflammatory Therapy For Graft Versus Host Disease
… biggest challenge in finding a therapy for GvHD. Bilirubin is a tetrapyrrole pigment, found in the blood, with natural anti-oxidative and anti-inflammatory properties. Using mouse models of various inflammatory diseases, studies by our collaborating investigators have shown that, water-soluble …
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Correlation Between Serum Bilirubin Level and Coronary Microvascular Integrity in Diabetic Patients
BACKGROUND AND OBJECTIVE: Bilirubin is a potent physiological antioxidants, it has been suggested that it may have a protective role in suppressing atherosclerosis and coronary artery disease. There has not been comparative studies for the relation of bilirubin level and coronary microvascular …
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Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level
Blood bilirubin level would be elevated when one's liver is unable to remove bilirubin sufficiently from the blood. The conventional methods used for monitoring and measuring the bilirubin level are time consuming, tedious and invasive in nature. This study aims to investigate the feasibility of …
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Development of a System Model for Non-Invasive Quantification of Bilirubin in Jaundice Patients
… between the production and elimination of bilirubin. Excess bilirubin in the blood stream diffuses into the surrounding tissue leading to a yellowing of the skin. An optical system integrated with a signal processing system is used as a platform to noninvasively quantify bilirubin …
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Neonatal Hyperbilirubinemia: <i>in vivo</i> Characterization of Mechanisms of Bilirubin Neurotoxicity and Pharmacological Treatments
Neonatal jaundice or hyperbilirubinemia is the result of alterations in the bilirubin metabolism. Prolonged and uncontrolled high levels of unconjugated bilirubin lead to bilirubin-induced neurological dysfunction and, if untreated, eventually death by kernicterus. Severe hyperbilirubinemia results …
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The incorporation of glycine-2-C14 into urinary uric acid and serum bilirubin in normal and porphyric subjects
The porphyrias are a group of disorders characterized by the excessive excretion of haem precursors in urine and stool. in the past two decades, isotopic studies led to impressive progress in our understanding of both normal and disordered porphyrin metabolism but despite these advanaces, many …
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Korrelation des Polymorphismus der Uridindiphosphat-Glukuronyltransferase Isoform 1A1 mit der Glukuronidierung von Bilirubin und Paracetamol und der klinischen Diagnose des Gilbert Syndroms
… von 0,35 vor. Es wurde gezeigt, daß die Höhe der Bilirubinspiegel und die Diagnose "Gilbert Syndrom" nach definierten klinisch-chemischen Kriterien gut mit dem Genotyp korreliert. Dabei lagen die mittleren Bilirubinwerte der Frauen deutlich unter denen der Männer. Die Festlegung neuer …
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ΣΥΜΒΟΛΗ ΣΤΗΝ ΠΡΟΛΗΨΗ ΤΟΥ ΠΥΡΗΝΙΚΟΥ ΙΚΤΕΡΟΥ. ΑΞΙΑ ΤΗΣ ΜΕΘΟΔΟΥ ΤΗΣ SEPHADEX G25 ΧΡΩΜΑΤΟΓΡΑΦΙΑΣ ΓΙΑ ΤΗΝ ΑΠΩΤΕΡΗ ΕΞΕΛΙΞΗ ΙΚΤΕΡΙΚΩΝ ΝΕΟΓΝΩΝ
… JAUNDICED NEWBORNS WITH NON ALBUMIN BOUND BILIRUBIN WHICH ARE PRONE TO MANIFEST LATER SIGNS OF BILIRUBIN ENCEPHALOPATHY. WE TESTED 78 BABIES (72%) OF 108 BABIES WITH JAUNDICE WITHOUT ANY OTHER MAJOR PERINATAL PROBLEMS. FROM THE FOLLOWED UP BABIES 55 HAD SEPHADEX (-) 16 HAD SEPHADEX SLIGHTLY …
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Weight, Temperature, and Transcutaneous Bilirubin of the Term Neonate at Discharge: A Comparative Study Between a Traditional Nursery and Rooming-in Model of Care
… change, body temperature, and transcutaneous bilirubin from a traditional nursery and a rooming-in model of care.</p> <p><strong>Design</strong>: A retrospective, descriptive, comparative design was used, comparing two groups for differences between outcomes.</p> <p><strong>Methods</strong>: A …
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Studies on the degradation of haemoglobin
… structure which is common to both haem and bilirubin. Prior to this, in vivo experiments on dogs performed by Mann, Sheard, Bollman and Blades showed that haemoglobin, injected into the arterial blood of the spleen or bone-marrow, produced a rise in the bilirubin content of the venous blood. …
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Biliverdin reductase in cardiovascular inflammation
… and catalyses the reduction of biliverdin to bilirubin. For over thirty years, BVR was regarded as rather a trivial enzyme whose only known function was to aid heme disposal. Over the last decade however, it has become increasingly clear that BVR is pleiotropic in function and for example, …
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Role of the Haem Oxygenase Pathway in Protection against Vascular Dysfunction
… rapidly converted to another potent antioxidant, bilirubin, by the cytosolic enzyme biliverdin reductase. Of the three known isozymes, the inducible isoform (HO-1) has been proposed to act as an effective system to counteract oxidant-mediated cell injury since it is extremely sensitive to …
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Incidence, aetiology and short term outcomes of extreme hyperbilirubinaemia, in term infants born in the West Metro area of Cape Town, South Africa between 2019 and 2020
Introduction: Extreme levels of bilirubin in the newborn is a major cause of lifelong neurodevelopmental impairment, which places a financial burden on healthcare resources and caregivers. Objective: To determine the incidence, aetiology and short term outcomes of extreme hyperbilirubinaemia in …
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Exploring acceptability and feasibility of a wearable device to facilitate home phototherapy treatment for newborn jaundice in rural Scotland: an interpretive description study.
… skin colour yellow due to the build-up of bilirubin. Internationally, jaundice continues to result in newborn infants' hospital admission, forcing separation of family units at the pivotal point for breastfeeding initiation and bonding. The aim of this research was to explore - with …
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Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters
… early rejection. Serial measurement of biliary bilirubin levels showed an early and significant decrease a few days prior to rejection, and were a more sensitive marker of graft function than serum bilirubin levels.
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Purification of uridine diphosphate glucuronyltransferase
… was monitored for three different substrates, bilirubin, 4-nitrophenol (PNP) and 7-hydroxy-4-methylcoumarin (HMC). For this last substrate, HMC, a new continuous fluorometric assay was developed. The purification fold and activity recovery, respectively, towards each substrate was as follows: …
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Assessment of serum cobalt binding with diseases of domestic cats
… at room temperature. Addition of conjugated bilirubin to serum was tested up to a total bilirubin concentration of 8.9 mg/dL (icteric index of 2+) and failed to have a clinically significant effect on the percent cobalt binding; however, severely hemolytic (≥4+) samples and even mildly …
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Novel Serum Biomarkers For Lung Cancer Early Diagnosis and Clinical Outcome
… then validated the most significant metabolite bilirubin as a risk marker for lung cancer incidence and mortality in a large prospective cohort comprised of 425,660 participants. In this cohort, the inverse association was only seen in male smokers. For every 0.1 mg/dL decrease of bilirubin, the …
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