Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Bile ducts"”.
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Morphology of the main bile ducts, with special reference to their musculature
… tr atise on the torm and structure of' th main bile ducta. Numerous oontributiona on different as ecta of the subject re constantly being added to the literature. ading theae articles, which re widely-scattered throughout the literature, indicates the neceasity tor integration and clarification …
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The role of the mechanical microenvironment in regulation of cholangiocyte specification and tubulogenesis
… I then employed this system to study bile duct specification and morphogenesis in vitro using well-established differentiation protocols (Hannan et al. 2013b; Sampaziotis et al. 2017). Through carefully controlling the ECM, I observed that high densities of collagen type I serve as an …
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Predicting Progression of Metabolic Dysfunction-associated Steatotic Liver Disease
… and malignant neoplasm of liver and intrahepatic bile ducts. We explore the possibility of using different machine learning techniques, including logistic regression, XGBoost, random forest, and decision trees to predict the likelihood of progression. We use data from Massachusetts General Brigham …
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Identifizierung und Charakterisierung von Pkhd1, dem Maus-Ortholog des humanen ARPKD-Gens, sowie Erstellung und Analyse einer Pkhdl mutierten Maus
… The murine Pkhd1 and its translation products have very similar properties to its human orthologue. Mouse Pkhd1 extends over approximately 500 kb of genomic DNA and includes a minimum of 68 exons. The longest ORF encodes the 4059-amino acid protein polyductin, predicted to have multiple …
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SODIUM/IODIDE SYMPORTER-NIS Abundant and Important in Gastric Mucosa
… including man, basolaterally in salivary gland ducts and apicolaterally in rat bile ducts. Weak NIS immunoreactivity was found basolaterally also in duodenal mucosal surface cells. Findings in gastric mucosa and salivary glands were confirmed by in situ hybridisation. Gastric iodide transport …
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Understanding regional diversity in the human biliary tree through transcriptomic profiling of primary tissues and in vitro derived organoids
… ductular tissues responsible for the drainage of bile produced by the liver and pancreatic secretions from the pancreas. The biliary tree is affected by a diversity of life- threatening diseases collectively called cholangiopathies. Cholangiopathies show regionalization, with some diseases such as …
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An investigation of the Ciliary Protein PKHD1 in Cyst development in liver disease: clues to the pathogenesis of Biliary Atresia
… that it localises specifically to intrahepatic bile ducts. Absence of fibrocystin staining in end-stage liver tissue reflects ongoing damage to the intrahepatic biliary tree, rather than a phenomenon specific to biliary atresia. Studies utilising the Pkhd1 \(^{del2/del2}\) mouse model of ARPKD …
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The differentiation of extrahepatic biliary atresia from the neonatal hepatitis syndrome
… severe cholestasis with patent extrahepatic bile ducts or poor uptake of the agent, and is therefore not diagnostic. This study has examined the quantitative measurement of the hepatic uptake of p-butyl IDA and Sn colloid, and an estimation of liver shape, in a group of patients with complete …
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Detektion von Sequenzvarianten mittels DHPLC : Etablierung als automatisiertes Verfahren zur direkten Mutationsanalyse bei autosomal-rezessiver polyzystischer Nierenerkrankung
… is associated with cystic malformation of the bile ducts and congenital fibrosis of the liver. The clinical spectrum ranges from intrauterine manifestation with prenatal demise to survival into adulthood. The very severe course of disease and the statistic risk of 25% for any newborn in …
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Study of the Phenotypic Characteristics and Genetic Risk Factors of Primary Sclerosing Cholangitis
… stricturing of the intrahepatic and extrahepatic bile ducts, often leading to biliary cirrhosis, with an increased risk of colorectal and hepato-biliary malignancy. It is commonly associated with inflammatory bowel disease (IBD). Specific medical therapy is ineffective and for patients who develop …
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Observations on myxozoans (Myzozoa: Myxosporea) and the spatial and temporal variation in parasite assemblages of the nosestripe klipfish, Muraenoclinus dorsalis Bleeke, 1860 (Perciformes: Clinidae)
… sp. 1 were found in the gall bladder and bile ducts, Kudoa sp. in skeletal muscle, and a Myxobolus sp. on the eyes. Spores of Ortholinea sp. were also detected in gall bladder squashes, but the actual location of infection is unknown. The endoparasite community composition and structure, …
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The Immunogenicity of Cholangiocyte Cellular Therapies
… for the transport and modification of bile. Cholangiocyte disorders, known as cholangiopathies, are a diverse group of life-threatening conditions characterised by cholestasis, ductopenia and eventual liver failure. There are currently no curative treatments for cholangiopathies aside …
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Fração prevenível da atividade física e câncer: revisão sistemática da literatura
… protective effect in cancer of prostate and bile ducts. For colorectal cancer the results diverged.
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Investigating the role of primary cilia loss in intrahepatic cholangiocarcinoma
… which protrude from the epithelial cells lining bile ducts (cholangiocytes), where they serve as sensors of bile composition, flow and osmolality. PC malformation has been reported in cholangiocarcinoma (CCA), a neoplasia that originates from these biliary epithelial cells. Despite changes in …
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Studies on protozoan parasites of small mammals
… microgametocytes in theepithelial cells of the bile ducts was investigated. Theultrastructure of the sexual and asexual stages were studied.In Trypanosoma (Megatrypanum) talpae, some preliminary aspects ofits reproduction in the mammalian host and the development inhaemogamasid mites was …
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Αποφρακτικός ίκτερος από ρήξη πρωτοπαθών νεοπλασμάτων του ήπατος εντός των χοληφόρων οδών
… and also to the abstruction of the intrahepatic bile ducts. On the contrary, the early appearance of obstructive jaundice as a result of obstruction in to the biliary tract by masses produced from the fusion of carcinoma caused by rupture of malignant primary liver tumores constitute rare …
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Determining the Oncological and Immunological Effects of Histotripsy for Tumor Ablation
… sparing nearby critical structures, such as bile ducts and blood vessels. Learning the safety dose-margins from the excised tissues, we performed an in vivo study using mice bearing patient-derived xenograft cholangiocarcinoma tumors. With this model, we were able to demonstrate our ability …
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An investigation of insulin-like growth factor binding protein-5 (IGFBP-5) as a biomarker for the detection of early liver disease
… cholangiocarcinoma, a type of cancer of the bile ducts in the liver. This project aims to determine whether IGFBP-5 could be used as a biomarker for detecting liver damage and fibrosis. Several models of liver disease were developed to determine if IGFBP-5 could potentially be a suitable …
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Development of Therapies to Treat Polycystic Kidney Disease
… filled cysts in the kidney tubules and liver bile ducts. There are two forms of PKD, autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD). The focus of the studies in this thesis has been on ADPKD. The disease progresses slowly and the …
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