Global ETD Search
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Showing 1 to 4 of 4 for “"Bile acid signaling"”.
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
Bile acids are synthesized from cholesterol in hepatocytes and secreted into bile. After a meal, bile acids are released from the gallbladder into the small intestine to facilitate the digestion and absorption of dietary fats and lipid soluble vitamins. Most bile acids in the intestine are …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
Bile acids, the end-product of cholesterol catabolism, are important for absorption and solubilization of lipids in the intestine because of their detergent properties. In addition to their roles as detergents, previous studies have revealed that bile acids function as signaling molecules in …
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Uncovering the role of bile acid signaling in facilitating sex differences during hepatocarcinogenesis and liver metabolism
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Identifying a role for the scaffolding protein IQGAP1 in liver health and disease
… impaired PPARα activation and hyperactive mTORC1 signaling. Furthermore, in chapter 4 I show that IQGAP1 is upregulated at a transcriptional level by bile acid signaling and its deletion results in increased toxin-induced liver injury and bile acid accumulation. E-cadherin, which is important for …