Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Bile acid metabolism"”.
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Role of TGR5 in Bile Acid Metabolism
TGR5 is a G protein-coupled bile acid receptor present in various tissues in the body. Its agonism increases energy expenditure and lowers blood glucose. Thus, it is an attractive drug target for treating human metabolic disease. However, TGR5 is highly expressed in the gallbladder, where its …
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Gut microbiota-mediated bile acid metabolism: implications for oral drug absorption
… has been primarily focussed on effects on drug metabolism, with minimal consideration to the absorption process (as reviewed in Chapter I). Thus, this thesis investigates a potential mechanism, ‘microbial bile acid metabolism’, by which the intricate interplay between the host and gut bacteria …
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Characterization of enzymatic pathways involved in cortisol and bile acid metabolism by the gut microbiota
… alter the physicochemical properties of bile acids with implications for increased/decreased toxicity for gut bacteria and the host. We located a gene-cluster in Eggerthella CAG:298 predicted to encode three HSDHs (CDD59473, CDD59474, CDD59475), synthesized the genes for heterologous …
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The Effects of Carbadox, a Synthetic Antimicrobial Agent, on Bile Acid Metabolism in The Domestic Pig
In order to study the bile acids of the young pig as they go through enterohepatic circulation without altering bile flow from the gall bladder, a surgical technique was developed to place indwelling catheters into the hepatic portal vein (HP) which allowed multiple sampling of the blood and did …
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Nutritional Regulation of Cholesterol 7alpha Hydroxylase (Cyp7a1) Expression
… into the changes in cholesterol, lipid, and bile acid metabolism in diabetes and obesity.
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Účinek agonistů nukleárních receptorů (FXR, CAR, aj.) na játra a hepatocyty za různých stavů
… important regulator of lipid, carbohydrate,and bile acid metabolism,and its activationmayinfluence metabolic andcellular processesrelevant toMASLD.FXR agonists are therefore being investigated as a potential therapeutic option for MASLD; however, their direct effects on hepatic mitochondrial …
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Einfluss einer ABCC6-Defizienz auf die Remodellierung der extrazellulären Matrix in in vitro und ex vivo Gewebemodellen
… of cholesterol in gallbladders and of cholic acid in serum indicated a shifted metabolite profile in bile acid metabolism and disruption of enterohepatic circulation in the Abcc6-/- mouse model.<br /> Remodeling of the ECM in PXE fibroblasts in two- and three-dimensional culture proved to be …
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Defining gut mediated metabolism for health and disease
… that human produced and microbially modified bile acids could act as an indicator of health. In chapter 3 we verified disruptions to bile acid metabolism in a porcine model of metabolic syndrome towards cardiovascular disease, induced by diet. In chapter 4 we applied dietary means to address …
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Antibiotic resistance in the gut microbiota
… on infant gut microbiota, the immune system and bile acid metabolism. We also sequenced the microbiota of the human vermiform appendix, highlighting its complexity. Finally, this thesis demonstrated the strain specific nature of 2 different probiotic CLA-producing Bifidobacterium breve on the …
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THE BIOTRANSFORMATION OF BILE ACIDS BY A COMMON MEMBER OF THE BISON GUT MICROBIOME
Bacterial biotransformation of bile acids (BAs) is increasingly recognized to play an important role in the health and disease of the host. Bile acid-modifying bacteria participate in the production of a large number of secondary BAs (2 BAs) with known and yet to be discovered activities. In the …
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The Impact of Vitamin D on the Epidemiology, Pathogenesis, and Treatment of Esophageal Adenocarcinoma
… incidence of esophageal adenocarcinoma. Refluxed acid and bile create an inflammatory milieu that in part may be mediated by 1,25(OH)2D by interacting with cyclooxygenase pathways, mitigating DNA damage, playing a role in bile acid metabolism, and influencing the immune cell population. …
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Machine learning and data analytics for liver disease modeling
… cholestatic liver disease characterized by bile duct inflammation, hepatic fibrosis, and a markedly increased risk of malignancy. Despite its severity, the underlying pathophysiology of PSC remains incompletely understood, and effective medical therapies remain lacking. This dissertation …
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The effects of bile acid sequestrants on the microbiome in the diagnosis and management of bile acid diarrhoea and post-operative Crohn’s disease
Bile acid diarrhoea is a poorly understood gastroenterological condition despite it affecting an estimated 1% of the general population. It can present concomitantly in other conditions such as post-cholecystectomy and Crohn’s disease, where it is found in over 90% of patients following a terminal …
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ENZYMOLOGY AND MOLECULAR BIOLOGY OF BILE ACID 7alpha- AND 7beta- DEHYDROXYLATION BY THE INTESTINAL BACTERIA CLOSTRIDIUM SCINDENS AND CLOSTRIDIUM HYLEMONAE
… microbiome, "the second human genome project". Bile acids, endogenously produced by the host liver, represent both a strong selective pressure for potential colonizers, aswell as substrates for microbial metabolism. Indeed, microbes have evolved enzymes to deconjugate bile salts, epimerize bile …
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Characterization of ARV1-Mediated Sterol Transport in Yeast and Mammalian Systems
… in intracellular cholesterol homeostasis and bile acid metabolism. 𝘈𝘙𝘝1-mediated decreases in 𝘈𝘙𝘝1 expression 𝘪𝘯 𝘷𝘪𝘷𝘰 occurred primarily in the liver and adipose. ARV1 ASO-treated animals did not exhibit UPR activation but were hypercholesterolemic and had increased levels of hepatic and …
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Effects of diet and loss of ovarian hormone production on adiposity, inflammation, cecal integrity, and gut microbial communities of rodent models
… objective of aim 2 was to determine the energy metabolism, lipid accumulation, and inflammation in adipose and liver tissues of OVX female C57BL/6J mice in response to a high-fat diet (HFD). Forty 10-wk-old female C57BL/6J mice were fed either a high-fat diet (HFD; 60% kcal from fat) or a …