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Showing 1 to 20 of 90 for “"Bile Acids"”.
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Liquid Crystal-Based Biosensors for the Detection of Bile Acids
Bile acids are physiologically important metabolites, which are synthesized in liver as the end products of cholesterol metabolism and then secreted into intestine. They are amphiphilic molecules which play a critical role in the digestion and absorption of fats and fat-soluble vitamins through …
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Bile Acids and Nuclear Receptors: Their Roles in Nutrition and Cancer
The bile acid receptor, also known as farnesoid X receptor (FXR), is essential for feedback regulation of bile acid synthesis. Bile acids are required for the proper absorption of dietary lipids, including fat-soluble vitamins; however, some bacterial metabolites of bile acids have been shown to …
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THE BIOTRANSFORMATION OF BILE ACIDS BY A COMMON MEMBER OF THE BISON GUT MICROBIOME
Bacterial biotransformation of bile acids (BAs) is increasingly recognized to play an important role in the health and disease of the host. Bile acid-modifying bacteria participate in the production of a large number of secondary BAs (2 BAs) with known and yet to be discovered activities. In the …
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Mechanisms into the development of fatty liver disease: role of bile acids, Betaine and MHY908
… remains elusive, though it is known free fatty acids such as palmitate promote liver injury. Therefore, there is a pressing need to find a potent therapeutic approach for NAFLD. Firstly, this study aimed to investigate the lipotoxicity and mitochondrial dysfunction attributable to palmitic acid. …
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Studies of Sulfur Reduction of Taurine and Taurine-Conjugated Bile Acids by Bile acid 7α-Dehydroxylating Bacteria
Bile acids are C24 steroids that are derived in the liver from cholesterol and secreted into the intestinal lumen to aid in emulsification of dietary lipids and lipid-soluble vitamins. The indigenous intestinal microflora modify bile acids, producing up to 20 unique bile acid metabolites. The …
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Chemical investigations into the physiology of bile acid skeletons
Bile acids are a class of surfactants that facilitate the digestion of dietary lipids and fat soluble vitamins in the intestines of vertebrates. Since they are the end products of cholesterol metabolism, bile acids biosynthesis is the major pathway to remove excess of cholesterol, which is another …
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ΚΙΝΗΤΙΚΗ ΜΕΛΕΤΗ ΚΑΙ ΑΝΑΛΥΤΙΚΕΣ ΕΦΑΡΜΟΓΕΣ ΕΝΖΥΜΙΚΩΝ ΣΥΣΤΗΜΑΤΩΝ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΧΟΛΙΚΩΝ ΟΞΕΩΝ ΣΕ ΒΙΟΛΟΓΙΚΑ ΥΓΡΑ
… KINETIC STUDY OF ENZYMATIC SYSTEMS USING BILE ACIDS AS SUBSTRATES AND ITS APPLICATION FOR THE DETERMINATION OF BILE ACIDS ARE BASED ON THE SPECIFIC OXIDATION OF THEIR HYDROXYL GROUPS BY NICOTINAMIDE ADENINE DINUCLEOTIDE (B-NAD+) OR BY B-NADP+ IN THE PRESENCE OF HYDROXYSTEROID …
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COMMUNITY STRUCTURES OF GUT MICROBIOME UNDER DIFFERENT DIETS IN ANGUS BEEF CATTLE
… the production of VFA and the composition of bile acids in beef cattle. We used rectum microbiota as a baseline and examined the microbiome in rumen and jejunum by16S-seq, together with quantifications of VFAs, lactate, and bile acids under grass-feeding and grain-feeding. We found that …
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The Role of OSTα-OSTβ and Bile Acid Transport in Intestinal Disorders Aand Metabolic Disease
Over the past 60 years, the study of bile acids has evolved from an esoteric source of fascination for chemists to becoming a field of enormous potential and discovery. Among their important physiological properties, bile acids function as critical detergents to solubilize biliary and dietary …
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Adding Upstream Sequence and a Downstream Reporter to the Bile Acid Inducible Promoter of <I>CLOSTRIDIUM scindens</I> VPI 12708
Bile acids in the small intestines of animals serve to breakdown fats and fatsoluble vitamins. Most of the bile acids are reabsorbed into the enterohepatic circulation, but approximately five percent of these bile acids pass into the large intestine. These bile acids are swiftly deconjugated by the …
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Part I: Synthesis of functionalized bile acids towards the construction of steroidal macrocycles. Part II: Evaluation and expansion of a modular card game for teaching organic chemistry
In Part I, the synthesis of chenodeoxychoic acid (CDCA) derivatives towards the construction of unique chemical architectures are reported. Building on previously described methods, CDCA based macrocycles with inner cavities have been synthesized and characterized. Attempts toward oxa-Michael …
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ENZYMOLOGY AND MOLECULAR BIOLOGY OF BILE ACID 7alpha- AND 7beta- DEHYDROXYLATION BY THE INTESTINAL BACTERIA CLOSTRIDIUM SCINDENS AND CLOSTRIDIUM HYLEMONAE
… microbiome, "the second human genome project". Bile acids, endogenously produced by the host liver, represent both a strong selective pressure for potential colonizers, aswell as substrates for microbial metabolism. Indeed, microbes have evolved enzymes to deconjugate bile salts, epimerize bile …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
… functions of SHP, maintaining cholesterol and bile acid levels by negative feedback regulation of hepatic conversion of cholesterol to bile acids is well established. Cholesterol is essential in many biological activities in mammalian cells. Conversion of hepatic cholesterol into bile acids is …
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
Bile acids are synthesized from cholesterol in hepatocytes and secreted into bile. After a meal, bile acids are released from the gallbladder into the small intestine to facilitate the digestion and absorption of dietary fats and lipid soluble vitamins. Most bile acids in the intestine are …
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Understanding the molecular mechanism through which aspirated bile triggers chronic Pseudomonas aeruginosa infections in respiratory disease
… and is associated with the presence of bile acids in the lungs of CF patients, a consequence of micro-aspiration of refluxed gastric contents. This thesis aimed to investigate the impact that bile exerts on the global lung microbiota and the key CF associated pathogen P. aeruginosa. The …
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
… should greatly advance our understanding of how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 signaling pathways, and SHP …
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Delineating the Steps of BAX Pore Activation
… and pore formation. Oxysterols and bile acids are physiological derivatives of cholesterol. Further employment of our vesicle leakage regime revealed that 25-hydroxycholesterol at low micromolar concentrations accelerates BAX pore formation, suggesting a compensatory mechanism for …
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The Role of OSTalpha/beta in Bile Acid and Lipid Metabolism
Bile acids are synthesized from cholesterol in the liver. Fecal bile acid excretion accounts for nearly half of daily cholesterol disposal. It has been known for many years that ileal resection or blocking intestinal apical absorption of bile acids induces hepatic bile acid synthesis. However, …
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The Effects of Carbadox, a Synthetic Antimicrobial Agent, on Bile Acid Metabolism in The Domestic Pig
In order to study the bile acids of the young pig as they go through enterohepatic circulation without altering bile flow from the gall bladder, a surgical technique was developed to place indwelling catheters into the hepatic portal vein (HP) which allowed multiple sampling of the blood and did …
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Discovering the biological and clinical implications of modulating glucocorticoid action using metabolomic profiling of human plasma samples
… action.Results: Branched chain amino acids, bile acids and their conjugates, and free fattyacids were the main metabolite groups that were significantly altered by at leasttwo of the three interventions. Compared to placebo, bile acids and theirconjugates were significantly (p < 0.05) …
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