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Showing 1 to 20 of 378 for “"Bile"”.
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Fibrinolysis by bile
A protease has been found in the bile of 11 mammalian species investigated. The protease, given the tentative name of cholelysin, has been studied intensively in Abattoir ox bile. It makes up less than 10% of the ox bile protein, and is a potent fibrinolysin, as well as being active against the …
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Calcium-binding system in bile
… of the cholesterol-solubilising system in bile. The cascade of data on this aspect of stone formation is contrasted with the lack of information on either the solubilising system for, or solubility properties of, the calcium salts in bile. The work described here aims to fill part of this …
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Studies of Sulfur Reduction of Taurine and Taurine-Conjugated Bile Acids by Bile acid 7α-Dehydroxylating Bacteria
Bile acids are C24 steroids that are derived in the liver from cholesterol and secreted into the intestinal lumen to aid in emulsification of dietary lipids and lipid-soluble vitamins. The indigenous intestinal microflora modify bile acids, producing up to 20 unique bile acid metabolites. The …
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Role of TGR5 in Bile Acid Metabolism
TGR5 is a G protein-coupled bile acid receptor present in various tissues in the body. Its agonism increases energy expenditure and lowers blood glucose. Thus, it is an attractive drug target for treating human metabolic disease. However, TGR5 is highly expressed in the gallbladder, where its …
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Physical properties and purification of bile pigments
… processes for the purification of the commercial bile pigments, to separate the impurities present in these products and examine them by spectroscopic means; and to prepare pure bilirubin for clinical use."
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Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects
… 40% of these patients have idiopathic bile acid malabsorption (BAM) – a condition with unknown aetiology. The 75SeHCAT test, which correlates inversely with faecal excretion and hepatic synthesis of bile acids, is used to diagnose BAM. The aims of the thesis were to study different …
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Chemical investigations into the physiology of bile acid skeletons
Bile acids are a class of surfactants that facilitate the digestion of dietary lipids and fat soluble vitamins in the intestines of vertebrates. Since they are the end products of cholesterol metabolism, bile acids biosynthesis is the major pathway to remove excess of cholesterol, which is another …
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The Effect of Bile Duct Cannulation on Plasma Lipoproteins
Made available in DSpace on 2014-12-05T19:06:52Z (GMT). No. of bitstreams: 1 6305083.pdf: 2927865 bytes, checksum: 74ee027b19a0c250c2c6905879f3f97d (MD5) Previous issue date: 1963
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The effects of bile acid sequestrants on the microbiome in the diagnosis and management of bile acid diarrhoea and post-operative Crohn’s disease
Bile acid diarrhoea is a poorly understood gastroenterological condition despite it affecting an estimated 1% of the general population. It can present concomitantly in other conditions such as post-cholecystectomy and Crohn’s disease, where it is found in over 90% of patients following a terminal …
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Changes in gall bladder bile throughout development in Rana catesbeiana
… weight; the relative surfactant activity of the bile; the change in major bile pigments. The most rapid and profound morphological and physiological transitions occur during the period of metamorphic climax. Because no information relative to change in anurans is available during this period, …
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Liquid Crystal-Based Biosensors for the Detection of Bile Acids
Bile acids are physiologically important metabolites, which are synthesized in liver as the end products of cholesterol metabolism and then secreted into intestine. They are amphiphilic molecules which play a critical role in the digestion and absorption of fats and fat-soluble vitamins through …
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Bile salt-stimulated human milk lipase characterisation and kinetic studies
… Chapter Three describes the purification of bile salt-stimulated human milk lipase (BSSL) from whole human milk. A detailed study of the activity of the purified protein has been conducted against both lipid and ester substrates in order to monitor the progress of the purification. A further …
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Surgical Strategy of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus
… for hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) have not been well assessed. This study intended to research the surgical strategy of HCC patients with BDTT. Methods: From February 1994 to December 2012, 877 HCC patients underwent hepatic resection in Ajou …
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Bile acid modulation of macrophage phenotype in colorectal cancer risk
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Role of Src phosphorylation of FXR in bile acid regulation
Bile acids are physiological detergents which aid in the absorption of dietary lipids and lipid soluble vitamins but also function as fed state signaling molecules. Elevated bile acid levels in the liver can lead to cholestatic injury, primary biliary cirrhosis, fibrosis, and liver cancer; …
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Nuclear Hormone Receptor-Mediated Changes of Cholesterol, Triglyceride, and Bile Acid Physiology in Response to Alterations in Cholesterol Absorption and Bile Acid Pool Size in Mice
… and physiological changes that occur with bile acid pool size restoration in mice that have a bile acid deficiency. This project highlighted the importance of bile acids in cholesterol absorption, the function of the bile acid-responsive nuclear hormone receptor farnesoid X receptor, and …
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Characterizing induced gene expression in Shigella flexneri following bile salt exposure
… Shigella utilizes host physiology, specifically bile salts as signals for invasion and virulence gene expression. This study aimed to build upon previous research analyzing the bile salts transcriptional profile of Shigella flexneri 2457T, in which an induction of the uncharacterized gene was …
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The Role of OSTalpha/beta in Bile Acid and Lipid Metabolism
Bile acids are synthesized from cholesterol in the liver. Fecal bile acid excretion accounts for nearly half of daily cholesterol disposal. It has been known for many years that ileal resection or blocking intestinal apical absorption of bile acids induces hepatic bile acid synthesis. However, …
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Study of the baiG Gene in Bile Acid 7α-Dehydroxylating Bacteria
Recently, intestinal bile acid 7α-dehydroxylating bacteria have been implicated in cholesterol gallstone disease. Eubacterium sp. strain V.P.I. 12708, a bile acid 7α-dehydroxylating bacteria, contains multiple bile acid inducible (bai) genes which are located on a large bai operon. Genes of this …
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