Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Biguanide"”.
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Analysis Of The Effects Of Metformin Administered Alone Or In Combined Treatments In Colorectal Cancer
… reversed after drug removal. When I combined the biguanide with the chemotherapy drugs commonly used to treat CRC I observed different responses in the cell lines analysed that reflected their genetic background and their different sensitivities to both the biguanide and chemotherapy. I found that …
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Development and validation of a cell based model of insulin resistance and investigation into the intracellular molecular defects induced by diabetes and obesity
… between the class of insulin sensitiser known as biguanides, and DNA repair mechanisms, as an initial characterisation of molecular links between diabetes and cancer. I established that inhibiting the DNA repair enzyme ATM reduces the phosphorylation of the biguanide target, AMPK in response to …
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Developing novel therapeutic agents for Acanthamoeba infection and investigating the process of encystment
… medical treatments involving polyhexamethylene biguanide or chlorhexidine despite the in vitro sensitivity of Acanthamoeba to these drugs. There is an urgent need for new therapeutic agents to eradicate the AK infection. This study focuses on the mechanism by which Acanthamoeba may distinguish …
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Novel cationic polymers for use at biological interfaces
… agents, in particular polyhexamethylene biguanide, has revealed that the essential components for the design of a novel polymeric antibacterial are a balance between hydrophilicity and hydrophobicity coupled with sites of cationicity. The effect of cation incorporation on the physical …
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An in-vitro study investigating current and novel antimicrobial agents as potential topical treatments for cutaneous infections caused by bacteria, fungi and Leishmania
… and EC50 assays. Results Polyhexamethylene biguanide (PHMB) is a widely used antiseptic and treatment agent. MIC/MBC and time-kill assays revealed no significant difference in activity between PHMB, polyamidopropyl biguanide (PAPB), and polyhexamethylene guanide (PHMG) (p > 0.05) for both …
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Mechanism of Metformin Action in Dermal Fibroblasts
… Alternatives to insulin therapy include biguanide drugs such as metformin. Metformin downregulates gluconeogenesis, and reduces blood glucose levels by activating glucose transport via GLUT4 in muscle cells. Importantly metformin has been shown to decrease mitochondrial respiratory …
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PREPARATION OF NANO- AND MOLECULAR COMPOUNDS FOR ANTITUMORAL APPLICATIONS TRIGGERED BY LIGHT
… of a luminescent molecule containing a terminal biguanide group to study how this moiety interacts with tumoral cells and can be related to the activity of the anti-diabetic drug metformin in inhibiting the proliferation of various types of tumors. Moreover, for three of these projects, a …
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Antibacterial and Laundering Properties of Ams and Phmb as Finishing Agents for Healthcare Workers Uniforms
… AEGIS Microbeshield, (AMS) and polyhexamethylene biguanide (PHMB) or Reputexâ · before laundering and after 5, 10, and 25 laundering cycles. The independent variables were the treatments (i.e., AMS, PHMB, no treatment) and the laundering cycles (i.e., 0, 5, 10, 25). The dependent variables were …
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Establishing an ex vivo model of acanthamoeba keratitis and investigating the phenotypic similarities between the protozoan acanthamoeba and human macrophages
… efficacy of doxycycline and polyhexamethylene biguanide (PHMB) in stopping the disease progression and the results demonstrated the ability of PHMB to inactivate Acanthamoeba trophozoites with minimal toxicity to the corneal epithelium. Doxycycline was not found to have any major antimicrobial …
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Metformin as a potential therapy for malignant astrocytoma
… alternative option. Metformin is from the biguanide family of drugs and is the most common medication used in the treatment of type 2 diabetes. Clinical studies have reported that, in type 2 diabetic patients, metformin might reduce cancer incidence and severity. Currently, metformin is …
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Nanocellulose-based materials for sustainable soil remediation and water purification
… metals from water. The grafted polyhexamethylene biguanide (PHMB) endows the biomimetic aerogel with exceptional bactericidal activity. The incorporated sericin protein brings abundant surface functional groups for heavy metal complexation. Moreover, this study provides in-depth insights into the …