Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Bicyclic peptides"”.
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Organometallic Palladium Reagents for Polypeptide Bioconjugation and Macrocyclization
Chapter 1: Bicyclic peptides have been developed to mimic good binders that structurally resemble antibody mimetics. The identity of the linker plays a critical role in enforcing the structure of the cyclic entity. Palladium-mediated arylation has enabled cysteine-specific modifications with a …
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Genetic selection of cyclic peptide G-quadruplex ligands
… This thesis commences the exploration of cyclic peptides as alternative chemical scaffolds for de novo G4 ligand generation. Widely used to generate protein binders as drug leads but relatively under-explored for nucleic acid targeting, cyclic peptides lie in the chemical space between small …
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Ligandability of protein-protein interactions and surfaces on Cullin RING E3 ubiquitin ligases
… extensive approach to probe the VBC surface with peptides. A first methodology involved the structure-based design aimed at targeting the Cul2 VBC interaction. Three peptides have been shown to bind at the Cul2 binding site on EloC, however, with very weak affinities that could not be optimised, …
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Peptide-mediated delivery of antisense oligonucleotides and chemotherapeutics across biological barriers
Many nucleic acids, peptides, and small molecules struggle to become clinically viable therapeutics as a result of poor delivery. Biological barriers such as the plasma membrane and the blood-brain barrier (BBB) contribute to this challenge as they can limit the passage of macromolecules. …