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Showing 1 to 20 of 169 for “"Bicyclic"”.
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Bicyclic Mixed Triple Systems.
… sufficient condition for the existence of a <em>bicyclic mixed triple system</em> based on the three possible partial orientations of the 3-cycle with twice as many arcs as edges. We also explore the existence of <em>rotational</em> and <em>reverse mixed triple systems</em>. Our principal proof …
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On the bicyclic acids of petroleum
… focused on the identification of the abundant bicyclic acids in petroleum and OSPW acid extracts, utilising the unparalleled chromatographic separation and mass spectrometric detection offered by GC×GC-MS. Analysis of fractionated NA as methyl esters, resulted in the first identification of …
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Flexible access to an array of optically-enriched conformationally-locked bicyclic morpholines and approaching bridged bicyclic piperazines
… into these synthetically challenging, strained bicyclic 6,5-systems. The aim was for the developed routes to be practically accessible, robust, and indeed flexible, to allow a diverse array of compounds to be obtained. Initially, work focused on the synthesis of the bridged morpholine scaffold, …
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Synthesis of Bicyclic and Tricyclic Analogues of Oxazolidinone
… and the Mitsunobu reaction, a series of fused bicyclic and tricyclic oxazolidinone-piperazine derivatives have been prepared. Using similar synthetic strategy and subsequent structural modification, the fused tricyclic piperazine analogues of ANB-22/40 have been successfully obtained as …
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Synthesis of the bicyclic core of pyrrolizidine alkaloids
… interested in developing a method to form the bicyclic alkaloid core that could be functionalized to generate many pyrrolizidine alkaloids. Specifically, our goal was to synthesize the pyrrolizidine B-ring by a novel McMurry cyclization strategy (Scheme 1). The synthesis of the McMurry reaction …
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Bridgehead Reactivity in Some Bicyclic and Tricyclic Systems
Made available in DSpace on 2014-12-10T23:01:52Z (GMT). No. of bitstreams: 1 7414549.pdf: 5862675 bytes, checksum: ee96cdc7c114dea1eab63fe68f33a7c1 (MD5) Previous issue date: 1974
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Bicyclic Heterocyclic Systems Derived from 1, 3, 4-Trisubstituted Pyridines
… pyridines and their conversion into bicyclic systems are reviewed. The work described in this thesis concerns the preparation of 1,3,4-trisubstituted pyridines, by both existing and novel routes, and the conversion of these precursors into bicyclic systems. Nucleophilic displacement …
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Plant Activation of Bicyclic Aromatic Amines, Benzidine and 4-Aminobiphenyl
Bicyclic aromatic amines, benzidine and 4-aminobiphenyl (4-ABP) have been known as human bladder carcinogens and used in industrial manufacturing. Using the plant cell/microbe coincubation assay, this study showed that benzidine and 4-ABP were activated by plant peroxidase into frameshift- and base …
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Syntheses and Reactions of Novel Bicyclic Aryldialkoxybrominane and Aryldialkoxyiodinane Oxide
The synthesis of 4-methyl-2,6-bis{1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl}aniline (2) in several steps from 4-methyl-2-{1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl}aniline (5) provides a necessary precursor for the incorporation of a stabilizing tridentate ligand in compounds of …
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Studies on Unsaturated Bicyclic Compounds With Nitrogen at the Bridgehead
Made available in DSpace on 2014-12-05T19:36:11Z (GMT). No. of bitstreams: 1 0013491.pdf: 4997510 bytes, checksum: c4995593e859900770991de96da8fa10 (MD5) Previous issue date: 1955
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Hydrogen bonded cavity and polymeric nanotubular assemblies from small bicyclic monomers /
… of supramolecular outcome of monomers containing bicyclic framework fused with isocytosine and/or ureidopyrimidinone motifs are discussed. The control over aggregation is attained by changing the size of the side chains and by attaching carbamide substituents at the isocytosine motif. Formation of …
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Synthesis of Partially Saturated Bicyclic Heteroaromatics: sp3-Enriched Scaffolds for Drug Discovery
… route for the synthesis of partially saturated bicyclic heteroaromatic scffolds (Figure i). The designed route takes advantage of the large chiral pool provided by amino acids, with each scaffold synthesised in just 4-6 steps from these readily available enantiopure starting materials. The mild …
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Chemistry of oxa- and aza-bicyclic(4.1.0)heptenes, total synthesis of (+)-pancratistatin
Vinyloxiranes 6a-b and vinylaziridines 7a-b were prepared efficiently from halocyclohexadiene-cis-diols 1. Reactions of 6 and 7 with a variety of organometallic reagents were investigated in order to determine the stereo- and regiochemistry of ring opening with carbon nucleophiles. The results …
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Application of Pd Catalyzed Alkylation: Synthesis of Bicyclic Furans, Isoxazolines and New Cyclopentane Amino acid Analogs
… in the field of palladium catalyzed synthesis of bicyclic furan analogs and provides a mechanistic explanation for these processes. Chapter 2 describes synthesis of new optically pure isoxazoline-2-oxide and furan analogs using Pd(0) catalyzed intramolecular cyclizations. Starting from a …
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Synthesis and Molecular Modeling Studies of Bicyclic Inhibitors of Dihydrofolate Reductase, Receptor Tyrosine Kinases and Tubulin
… developed for tgTS and hTS using a set of 85 bicyclic inhibitors and for RTKs using a set of 60 inhibitors reported by Gangjee et al. The resultant models could be used to explain the potency and/or selectivity differences for selected molecules for tgTS over hTS. Topomer CoMFA maps show …
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Conformational Study of the Mercuric Acetate Oxidation of Tertiary Aminoalchohols, Bicyclic Oxazolidines and Tetrahydro-1,3-Oxazines
Made available in DSpace on 2014-12-05T19:37:50Z (GMT). No. of bitstreams: 1 6200573.pdf: 3820404 bytes, checksum: 9ba6cdb27b89176ee53f8649e831f9de (MD5) Previous issue date: 1961
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