Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Biased agonism"”.
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Functionally selective receptor signaling and endocytosis by dopamine D1 receptor agonists
… Functionally selective agonists, also known as biased agonists, may fine-tune receptor signaling to improve therapeutic efficacy and/or reduce adverse effects. However, the mechanism-of-action for D1R biased agonists is not clearly defined and the function of Gs/olf and β-arrestins in D1R …
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Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling
… receptors have been implicated in this novel biased signaling pathway. Therefore, the present study aimed to investigate whether CB2 GPCRs are similarly involved in the proposed signaling paradigm to induce epithelial-mesenchymal transition (EMT) and a metastatic phenotype. Synthetic CB2 …