Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Bexarotene"”.
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Synthesis and Characterization of Bexarotene Derivatives with Potential Biological Activity // Получаване и охарактеризиране на бексаротенови производни с потенциална биологична активност
… derivatives of the synthetic retinoid bexarotene. The continued and intensive study of the role of retinoids in the complex of differentiation, cell proliferation, and cellular growth processes determines the major potential for the using of retinoids (natural and synthetic) in the …
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Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry
… the synthesis of sila-venlafaxine, disila-bexarotene, disila-AG-045572 (disila-CMPD1), a series of silicon-based allosteric modulators of muscarinic receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, (R)-sila-venlafaxine …
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Growth and Toxicity of Amyloid β Polymorphs
… of a potential Alzheimer’s drug candidate, bexarotene, on Aβ fibrillization using powerful techniques. Bulk kinetics studies suggested that bexarotene interferes with the primary nucleation step. Cryo-electron microscopy revealed that bexarotene enforces a distinct molecular structure …
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An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity
… thesis focuses on the immunological effects of bexarotene. This retinoid X receptor agonist is currently being tested in a phase II clinical trial for its ability to promote remyelination [“CCMR One” trial]. Here, we focused on the ability of bexarotene to modulate the human Th17/iTreg axis in …
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Design and development of novel tools for the screening and identification of inhibitors of HER receptor family and NFR2 for ovarian cancer therapy
… inhibition using retinoic acid (RA) and bexarotene and genetic inhibition using small interfering RNA (siRNA), did the opposite. Further, tBHQ caused transcriptional induction of HER1 and HER4 with different levels of expression, while siRNA-mediated knockdown of NRF2 prevented this and …
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Promoting and measuring remyelination and neuroprotection in clinical trials of people with multiple sclerosis
… factors. In this PhD I show that bexarotene, a non-selective agonist of the RXR receptor, promotes remyelination in people with relapsing remitting multiple sclerosis. Converging evidence from electrophysiology and neuroimaging in a phase II clinical trial (CCMR One) demonstrate …
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Development & testing of ultrasound enhanced prodrug microbubble drug delivery system
… novel microbubble formulation using a prodrug of Bexarotene to make the exterior layer of the microbubble. This started with development and engineering of productions schemes for stable microbubbles. Physical characterization was done to confirm production and was followed by initial in vitro …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
… in aged macrophages. The FDA-approved agonists bexarotene and pioglitazone, when used in concentrations achievable in human subjects, caused a reversion of the gene expression profiles in MS patient monocytes to a more youthful profile and enhanced myelin debris phagocytosis by patient cells. …
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Visual Outcome Measures of Remyelination and Neuroprotection in Multiple Sclerosis
… Phase IIa randomised, controlled trial assessing bexarotene as a remyelinating drug. These particular blood biomarkers may be better suited for longer-duration trials. When correlated to VEP, only NfL was suggestive of a potential remyelinating-induced neuroprotective effect as driven by …
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Retinoid X Receptor as a Mediator of Post Stroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Macrophages
… mice for transcriptomic analysis. RXR agonist bexarotene (BEX; 5 mg/kg) or vehicle were intraperitoneally (i.p.) injected daily for three days prior to harvest (n=3/group). We found that compared to young adults, MG from the aged brains expressed higher levels of pro-inflammatory genes and …