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Showing 1 to 16 of 16 for “"Betamethasone"”.
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Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations
… concerning the stability of the drug substances betamethasone 17-valerate and fusidic acid hemihydrate in topical pharmaceutical formulations. In particular, the work concentrates on formulation factors affecting the intra-molecular isomerisation of betamethasone 17-valerate to 21-valerate in a …
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Interaction of ACTH and Estradiol in the Regulation of Growth, Differentiation, and Steroidogenic Maturation of the Baboon Fetal Adrenal Gland
… modulates ACTH actions. Administration of betamethasone (3mg/day) to baboon mothers on days 60-99 of gestation and to the fetus (0.6 mg/, n = 4) or to the fetus (0.6mg) and mother (6 mg/ml; n = 4) every other day between days 150-164 of gestation (term = 184 days) decreased (P …
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Topical Steroids, an alternative to circumcision for treatment of Phimosis at the University Teaching Hospital,Lusaka
… management by a topical steroid namely betamethasone cream of 0.1 %. Of these 125 patients, 85 (68.0%) received topical steroid therapy as primary treatment and they were termed" new cases", while 40 (32.0%) were "recurrent" phimosis some weeks after dilatation before the commencement of …
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The metabolism of cortisol in the human feto-placental unit
… fetuses, after treatment of betamethasone to the mother (12 mg/day for one or two days). The mean value of cortisol in samples from fetuses delivered up to 24 hours after treatment was 2.6 ± 2.2 µg/100 ml (n = 4) and the mean value of cortisone was 2.2 ± 2.2 µg/100 ml (n = …
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Long-term impacts of antenatal corticosteroid exposure and preterm birth
… syndrome in the group randomised to antenatal betamethasone. We followed up the adult offspring of participants in this trial using a health questionnaire and routinely collected data. Of 1,218 infants born to 1,115 women, 424 participants were included at mean age 49.3 years (46% of …
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Studies on the Formulation of Topical Corticosteroids
The stabilities of betamethasone-17-valerate and hydrocortisone-17-butyrate have been investigated. It has been shown that the 17-esters undergo acyl migration to the 21-isomers. These 21-isomers hydrolyse to the free alcohols which further degrade to other products. In order to elucidate the …
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NEUROINFLAMMATION AND SEX-DEPENDENT SIGNALING WITHIN THE DORSAL MEDULLA IN A MODEL OF FETAL PROGRAMMING: EFFECTS OF ANGIOTENSIN-(1-7) SUPPLEMENTATION
Administration of glucocorticoids (GCs) such as betamethasone (BM) for women in jeopardy of preterm labor between 24 and 34 weeks gestation is a highly successful therapeutic intervention resulting in decreasing infant mortality. The immediate effects of BM therapy are beneficial to the offspring, …
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Alterations in the Brain Renin-Angiotensin System in a Model of Fetal Programming
Antenatal betamethasone (BM) is an approved therapy for women threatening early preterm labor between 24 and 34 weeks gestation. The immediate effects of BM therapy are of benefit to the offspring, as fetal steroid exposure decreases infant mortality by accelerating lung and gastrointestinal tract …
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The effects of topical calcipotriol treatment on immune responses to vaccination
… topical immunosuppressant, the corticosteroid betamethasone-17-valerate (BMV). Functionally, calcipotriol and BMV treatment both result in the suppression of CD8⁺ T cell priming in response to subcutaneous vaccination, despite the topical co-administration of the potent Th1 inducing TLR9 …
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Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo
… including; drug choice (Dexamethasone, Dex, or Betamethasone, Beta), and drug formulation. There is increasing animal and human data that suggest exposure to high doses of synthetic glucocorticoids may have a detrimental effect on the fetal cardiovascular system. The chicken embryo model was …
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Determination of illegal and toxic ingredients in face creams
… Other steroids identified included Cortisone, Betamethasone Dipropionate (BD), Betamethasone (BM), and Fluocinolone, found in 12%, 12%, 4%, and 4% of the samples, respectively. Hydroquinone (HQ) was present in 16% of the samples, with concentrations ranging from 0.096% to 4.301%, particularly …
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Analytics of endocrine disrupting chemicals in environmental matrices
… staal verdacht was voor dexamethasone (Dxm) of betamethasone (Btm), vloeistofstofchromatografie gekoppeld aan massaspectrometrie (LC-ESI-MS-MS) ingezet ter bevestiging. Dit onderzoek toonde aan dat de combinatie van GC- en LC-MS-MS de detectie van steroïdhormonen in lage ng.l-1 concentraties in …