Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 112 for “"Beta-cell"”.
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Evaluation of radiotracers for beta cell imaging
Contains fulltext : 169275.pdf (Publisher’s version ) (Open Access)
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Mitochondrial Involvement in Pancreatic Beta Cell Glucolipotoxicity
… fatty acid (NEFA) levels can cause pancreatic β-cell failure. The molecular mechanisms of this β-cell glucolipotoxicity are yet to be established conclusively. In this thesis by exploring mitochondrial energy metabolism in INS-1E insulinoma cells and isolated pancreatic islets, a role of …
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ADP regulation of insulin secretion and beta-cell apoptosis
… were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the …
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Beta Cell Heterogeneity in the Acute Interferon Alpha Response
… destruction of the insulin-producing β-cells in the pancreatic islet. This autoimmunity is hypothesized to result from a combination of genetic and environmental factors, with early childhood viral infection being a leading hypothesis for the latter. In response to viral infections, the …
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The Role of Sox17 in Normal and Pathological Beta Cell
… which are also known regulators of postnatal β cell function. Our data shows that Sox17 is expressed in all islet cells. Thus, we hypothesize that Sox17 is a key modulator of β cell homeostasis.</p><p>In the course of this study, we discovered a novel role for Sox17 in regulating insulin …
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Role of PARK2Gene in Maintenance of Pancreatic Beta Cell Functions
… between the PARK2 gene and pancreatic β-cell dysfunction-related T2D. In order to prove this finding experimentally, I first investigated whether the PARK2 gene is expressed in the pancreatic tissues. Gene expression profiling of the Park2 gene in rats showed its predominant expression in …
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Exploring Beta Cell NADPH production using Organelle-targeted Apollo-NADP+ Sensors
A major function of beta cells is the production and secretion of insulin to maintain glucose homeostasis. Loss of this function is directly linked to progression of diabetes. The loss of beta cell function is exacerbated by cellular senescence associated with natural aging. Senescence impacts …
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Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
… METABOLIC DYSFUNCTION OF THE PANCREATIC BETA-CELL</p> <p> by</p> <p>ABIY MUSSA MOHAMMED</p> <p>August 2013</p> <p>Advisor: Dr. Anjaneyulu Kowluru</p> <p>Major: Pharmaceutical Sciences</p> <p>Degree: Doctor of Philosophy</p> <p>Type I diabetes is characterized by an absolute insulin …
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Novel Roles of Gastrin and Cholecystokinin in Islet Beta Cell Proliferation
… 2 diabetes share a common theme: an insufficient beta cell mass to maintain glucose homeostasis. In Type 1 diabetes this deficiency arises from autoimmune destruction of the beta cells. In the latter stages of Type 2 diabetes, there is a precipitous drop in beta cell mass, resulting from the …
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New Roles of the Transcription Factor NKX6.1 in Beta Cell Biology
Pancreatic islet beta cells play a critical role in the maintenance of metabolic fuel homeostasis. Type 1 diabetes results from autoimmune destruction of the beta cells, whereas type 2 diabetes involves loss of beta cell function, particularly glucose-stimulated insulin secretion (GSIS), and a …
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Lipid metabolism in the pancreatic beta-cell. Implications for insulin secretion.
… the role of lipid metabolism with regard to beta-cell function and insulin secretion. Lipids are known to play a crucial functional role in the pancreatic beta-cell, where they are essential for adequate hormone release, but may also exert a long-term toxic effect, leading to beta-cell …
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Spinophilin Signaling: Impacts on Body Weight, Obesity, and Beta-Cell Function
… caused by dysfunction of the insulin-producing beta cells of the pancreas. However, mechanisms that promote obesity and the mechanisms by which obesity leads to beta cell dysfunction are not fully known. Spinophilin is a filamentous (F)-actin binding, protein scaffolding, and protein phosphatase …
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Molecular Adaptation of Pancreatic Beta-Cell Function During Endoplasmic Reticulum Stress
Pancreatic beta-cells may balance glucose-stimulated insulin synthesis and secretion with the proteasome activity to regulate protein concentrations in the endoplasmic reticulum (ER). During this process, reactive oxygen species (ROS) may originate as byproducts from the oxidative protein folding …
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Mechanism of genistein in the regulation of pancreatic beta-cell proliferation
… derived primarily from legumes, on pancreatic β-cell proliferation and the related molecular mechanisms. Diabetes mellitus is a major and growing public health problem worldwide. Both in type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by …
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THE VASCULAR RESPONSE WITHIN THE ISLET DURING BETA CELL DEVELOPMENT AND REGENERATION
… capillary bed, to develop into the appropriate cell type. The neonatal rat pancreas undergoes a developmental β cell turnover that involves the apoptosis of immature β cells and their replacement with adult β cells. To further elucidate this mechanism and the potential role of the vascular …
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Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function
… of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. The exocytotic process is crucial for beta cell function and its dysregulation leads to impaired insulin secretion. Therefore, understanding the central mechanisms …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… and free fatty acids (FFAs) induces pancreatic beta cell dysfunction and death, which may contribute to the development of type 2 diabetes. A deficiency of insulin through loss of beta cell mass, and subsequent impaired compensation against insulin resistance is believed to be a pathogenic cause …
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… nor does it change glucose uptake into primary beta cells. VitD does however increase glucose-stimulated calcium uptake, suggesting that VitD affects transcription of genes involved in calcium flux into the beta cell. To identify molecular mechanisms linking VDR activity to increased insulin …
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Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function
… different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). When activated, these receptors are able to fine-tune islet hormone secretion and regulate overall β-cell function. Estrogen and serotonin are circulating factors that bind to GPCRs. First, we …
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Stress-inducible Mig6 promotes pancreatic beta cell destruction in the pathogenesis of diabetes
Pancreatic insulin-secreting beta cell failure is central to the development of diabetes. Therapeutic applications targeted at understanding and manipulating beta cell destruction mechanisms should enhance the preservation of functional beta cell mass and prevent diabetes. To this end, we have …
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