Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Beta-adrenoceptor"”.
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Beta-adrenoceptor blockade and stimulation in obstructive lung disease
Contains fulltext : mmubn000001_029174244.pdf (Publisher’s version ) (Open Access)
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Soft [beta]-adrenoceptor agonists for topical use in psoriasis
… levels. This thesis describes a series of β-adrenoceptor agonists for topical delivery based upon the soft-drug approach. Soft drugs are defined as biologically active, therapeutically useful chemical compounds (drugs) characterised by a predictable and controllable In vivo destruction …
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The electrophysiological and molecular effects of chronic beta-adrenoceptor antagonist therapy on human atrium
The chronic treatment of patients with a β-adrenoceptor antagonist is associated with prolongation of the atrial cell action potential duration (APD), potentially contributing to the ability of these drugs to prevent atrial fibrillation (AF). The mechanisms underlying this APD prolongation are not …
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Arrhythmogenic potential of alpha-adrenoceptor stimulation in the rat heart
A recent proposal is that the alpha₁-adrenoceptor may mediate the arrhythmogenic effect of catecholamines during acute myocardial ischaernia. The purpose of this thesis was to explore the role of alpha₁ and alpha₂-adrenoceptor stimulation on vulnerability to ventricular fibrillation in the …
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The linking of angiogenesis to contractile performance and substrate metabolism in the hypertrophied and failing heart
… ventricular capillarity (e.g. hypertension and beta-adrenoceptor stimulation). In contrast to previous reports, capillary growth within the ventricle was very limited in animals exposed to a chronic increase in energy demand (e.g. cold environments) and those subjected to extended periods of …
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Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias
… O₂ and substrate deprivation. 3 . To explore beta-adrenoceptor mediated ventricular automaticity. 4 . To evaluate possible new anti-arrhythmic drugs, carminomycin and ketanserin.
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Adrenergic regulation of splenic functions in neonatal pigs
… of the splenic nerve. Pretreating the NP with beta-adrenoceptor blocker, propranolol (1 mg/kg), had no significant effect on these responses. In contrast, these responses were abolished with the addition of alpha-adrenoceptor blocker, phentolamine (1 mg/kg). Splenic O₂ metabolism did not change …
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Vectorcardiographic evaluation of ventricular repolarization in healthy individuals and LQTS mutation carriers
… and VR, while similar increase in HR by β-adrenoceptor stimulation or vagal withdrawal had different effects on VR and resulted in changes that could increase arrhythmia risk. 2. At supine rest there was a modest but significant difference in QTcB but otherwise no difference in VR measures …