Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Beta-Sheets"”.
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A Novel Statistical Potential for Protein Beta-Sheets Prediction
… prediction problems, a fundamental problem is Beta-sheets structure prediction. Though more than 85% of experimentally solved proteins contain Beta-sheet structures, limited methods have been found to rapidly and accurately predict the folded conformations. In this study, we proposed a novel …
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Design and synthesis of constrained dipeptide units for use as β-sheet promoters
The study of factors promoting beta-sheet formation has recently gained interest due to the suspected involvement of beta-sheets in brain degenerative diseases such as Alzheimer's disease (AD), Creutzfeldt-Jacob disease (CJD) and bovine spongiform encephalopathy. Understanding beta-sheet formation …
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A Fragile Native State Structure: An Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Variant Exhibits Slow Interconversion Kinetics Between two Different Folds
… with several other bHLH-PAS proteins via the beta-sheet surfaces of its two PAS domains. The beta-sheets of PAS domains are involved in many intermolecular interactions with other proteins and natural cofactors in order to detect environmental changes in sensor PAS proteins. As part of a study …
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Structural studies of amyloid fibrils using solid-state NMR
… accurate distance measurement across parallel [beta]-sheets in amyloid fibrils has been developed. This method combines the a double quantum filtered version of the dipolar recoupling sequence DRAWS with the simulation and data fitting program SPINEVOLUTION to provide a simple and effective way …
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Prediction of parallel in-register amyloidogenic beta-structures In highly beta-rich protein sequences by pairwise propensity analysis
… are clinically and biologically important beta-structures, whose supersecondary structures are difficult to determine by standard experimental or computational means. In addition, significant conformational heterogeneity is known or suspected to exist in many amyloid fibrils. Recent work …
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Sequence-structure correlations in the MaSp1 protein of N. clavipes dragline silk
… the formation of a robust cross-linking the [beta]-sheet crystal. Confirming earlier experimental and computational work, a structural analysis reveals that poly-alanine regions in silk predominantly form distinct and orderly [beta]-sheet crystal domains while disorderly regions are formed by …
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OspC in the pathogenesis of Borrelia burgdorferi
… alpha-helical with 5 alpha helices and 2 beta sheets interconnected by 6 loops, and an N- and C-terminus. Not much is known as to how the OspC structure relates to the function of the lipoprotein and/or possible regulation. The up-and down-regulation of OspC is achieved by the rpoS …
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Structural and mechanical properties of intermediate filaments under extreme conditions and disease
… mechanism of a transition from alpha-helices to beta-sheets with subsequent intermolecular sliding under mechanical force, which has been inferred previously from experimental results. This nanoscale mechanism results in a characteristic nonlinear force-extension curve, which leads to a …
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Application of Functional Amyloids in Morphological Control and in Self-assembled Composites
… are self-assembled protein materials containing beta-sheets. While most studies focus on amyloids as the pathogen in neurodegenerative disease, there are instances of "functional" amyloids used to preserve life. Functional amyloids serve as an inspiration in materials design. In this study, it is …
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Computer Simulation of Biological Systems
… to form temporary secondary structures like beta-sheets or alpha-helices.
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Assay Development for Tau-directed Therapeutics
… as well as the number and positioning of the beta-sheets. In vitro induced tau filaments commonly used to screen therapeutics have also been observed to have structures which are not similar to those found in diseases. We hypothesize that screening therapeutics against tau aggregates with …
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Self-assembled Peptide Hydrogels for Therapeutic H2S Delivery
… APAs formed nanofibers, which were stabilized by beta-sheets and aromatic stacking. The self-assembled structures were affected by the substituents on the aromatic rings of SATOs, leading to the formation of twisted nanofibers. After the addition of cysteine, H2S was released from the APAs with …
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Model membrane interactions with ions and peptides at the air/water interface
… with two different peptides B18 and Amyloid beta (1-40) peptide were investigated. B18 is a synthetic peptide that binds to lipid membranes that leads to the membrane fusion. It was demonstrated that it adopts different structures in the aqueous solutions and in the membrane interior. It is …
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Computational Development for Secondary Structure Detection From Three-Dimensional Images of Cryo-Electron Microscopy
… elements (SSEs) such as alpha-helices and beta-sheets can still be detected. The accuracy of SSE detection from the volumetric protein density images is critical for <em>ab initio</em> backbone structure derivation in cryo-EM. So far it is challenging to detect the SSEs automatically and …
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Phase Phenomena of Proteins in Living Matter
… monomer to pentamer, with extended inter-domain beta sheets appearing first, then multi-sheet `intramolecular amyloid' structures, and finally novel motifs containing alpha helices. Finally, in developing principles of protein behavior \emph{in vivo}, we discuss the implications and connection to …
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Characterization of a single TRAM domain RNA-binding protein from the Antarctic methanogen Methanococcoides burtonii
… at -2 degrees. Ctr3 and Csps both form a beta-barrel shape with anti-parallel beta-sheets that form a nucleic acid binding surface. The broad representation of single TRAM domain proteins within Archaea compared to their apparent absence in Bacteria, and scarcity of Csps in Archaea but …
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Incorporation of Cα,α-Disubstituted Amino Acids into Model Peptide Systems: Conformational Analysis and Possible Applications as Therapeutic Agents
… and stability. Peptides that autonomously form β-sheets are ideal models to study principles of protein folding and design. Gellman and coworkers first introduced an automonously folded β-hairpin (H-Arg-Tyr-Val-Glu-Val-Yyy-Xxx-Orn-Lys-Ile-Leu-Gln-NH2) that remained monomeric up to ~1 mM. Circular …