Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Beta-Peptide"”.
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A renewed vision for Amyloid beta and tau in Alzheimer s disease pathophysiology
… involved in AD pathogenesis, i.e. Amyloid-beta peptide and tau protein, on hippocampal synaptic plasticity and memory in animal models. After reviewing the pathophysiological models that have been developed so far, our general purpose was to study novel aspects of Amyloid-beta peptide and …
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X-ray Spectroscopic Studies of Model Compounds With Relevance to Nickel Superoxide Dismutase, Nitrile Hydratase and Copper Related Neurodegenerative Disorders
… of oxidation of the Cys residues. A metallopeptide mimic was synthesized and then sequentially oxygenated to its active form, a sulfinate (SO<sub>2</sub>) and a sulfenic acid (SOH). Over or under oxidation result in no activity of the metellopeptide mimic. The Aβ (amyloid-β) …
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Targeted magnetic nanoparticles for remote manipulation of protein aggregation
… magnetic hyperthermia treatment to the amyloid beta (A[beta]) peptide, which unnaturally folds and self-assembles forming amyloid fibrils and insoluble plaques characteristic of amyloidgenic diseases such as Alzheimer's disease. We demonstrate remote disaggregation of A[beta] aggregates using …
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Influence of Kaempferol on Noncanonical DNA Structures and Protein Aggregation
… as delay the formation of b-sheet in amyloid-beta peptide (Ab) further eluding to the potential of KMP as a possible natural therapeutic drug.</p>
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Investigating the process of fibril formation of the Iowa mutant of the Alzheimer's peptide
… this study is to determine how the length of the beta-amyloid peptide, the specific region of the peptide, and a single point mutation affect the behavior of Alzheimer’s beta-amyloid. The beta-amyloid peptide, which is a 40 residue peptide that has been implicated as a potential cause of …
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Mechanisms of Brain Region-Specific Amyloid-beta Deposition
… plaques principally comprised of the amyloid-β: Aβ) peptide. Using mouse models of cerebral Aβ deposition, we examined molecular, cellular and systems-level mechanisms that regulate brain region-specific Aβ accumulation and aggregation. Parallel studies using in vivo …
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Alzheimer's disease and dementia with Lewy bodies: Special focus on the role of serpins
… plaques, mainly composed of aggregated amyloid-beta peptide (Abeta1-42), but also serpins, and neurofibrillary tangles of hyperphosphorylated tau protein. Pathological hallmarks of DLB include aggregates of alpha-synuclein (Lewy bodies), however, co-existing AD pathology is also frequently …
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Observations on cerebral amyloid angiopathy and microvascular pathology in Alzheimer's disease and vascular dementia
… the interrelationship between the amyloid beta (A-beta) peptide species deposited is affected by the presence of cerebrovascular disease, which is associated with a relative increase in deposition of the more fibrillogenic and toxic variant of the Ab peptide, and more severe degeneration of …
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
… aggregation and accumulation of the amyloid beta peptide in the brain is hypothesized to be an initial necessary event in the pathogenesis of Alzheimer's disease (AD). Since the level of monomeric soluble amyloid beta as well as amyloid beta-binding molecules determine the onset and amount of …
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Order, disorder, and protein aggregation
… of amyloid fibril elongation in the Amyloid-[beta] (A[beta]) peptide of Alzheimer's disease. I compute the free energy surface associated with the fibril elongation reaction, and find that elongation of both A[beta]40 and A[beta]42 experimental fibril structures occurs on a downhill free …
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Dynamic Measurement Of Soluble Human Aβ In A Combined Microdialysis-Experimental Traumatic Brain Injury Mouse Model
The amyloid-β peptide: Aβ) plays a central pathophysiological role in Alzheimer's disease, but little is known about its dynamics in the brain's extracellular space. A recent microdialysis-based study in human patients with severe brain injuries found that extracellular Aβ dynamics …
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Purification and characterization of A[beta] and probing the interactions between myricetin and A[beta] using various spectroscopic methods
… occurring protein fragment, the amyloid [beta]-peptide (A[beta]). Soluble oligomers of A[beta] are now considered to be the primary neurotoxic agent. Naturally occurring flavonoid compounds have been reported to inhibit/reverse A[beta] aggregation and reduce the A[beta]-induced …
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An interdisciplinary approach to studying mechanistic, structural and toxic features of protein aggregates associated with neurodegenerative disorders.
… species of the 42-residue form of the A$\beta$ peptide (A$\beta$42) are responsible for the membrane disruption. The methodology can be applied to the study of other proteins such as $\alpha$-synuclein and tau, and the ability of antibodies and chaperones to counteract the aggregate …
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Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model
… aggresomes. Lastly, I studied a yeast model of A[beta] 1-42 toxicity. Accumulation of the amyloid beta peptide is thought to be causal in both sporadic and familial Alzheimer's disease. In collaboration with Kent Matlack I developed a yeast model that expressed A[beta] 1-42 in a manner …
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The Role of Apolipoprotein E Concentration and Isoform in Amyloid-beta Metabolism In Vivo
… one of which is the accumulation of the amyloid-β: Aβ) peptide into extracellular amyloid plaques. Several autosomal dominant mutations have been shown to cause familial forms of early-onset Alzheimer's disease, but factors that modulate the risk and onset for the more common sporadic, …
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Model membrane interactions with ions and peptides at the air/water interface
The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated biochemical processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. …
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EXPLORING THE EFFECTS OF PHYSIOLOGICAL ENVIRONMENT ON AMYLOID AGGREGATION
… have focused on different fragments of Amyloid-beta peptide and Huntingtin protein and explored common interaction schemes in the presence of phospholipid membranes, solvated glucose molecules and added trailing sequences. Phospholipid membranes, composed of a heterogeneous distribution of lipid …
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The Role and Immunogenicity of CBFA2T3-GLIS2 in Pediatric Acute Megakaryoblastic Leukemia
… which uses heterodimers consisting of alpha and beta peptide chains to recognize polypeptide fragments presented by HLA molecules on the tumor cells. An advantage of this approach is the ability to recognize intracellular tumor specific and tumor associated antigen fragments in addition to …
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Berechnung des Circulardichroismus von beta-Oligopeptiden und Oligonucleotiden mit dem klassischen 'Dipole Interaction Model' und der quantenmechanischen Matrixmethode
… this thesis the CD-spectra are calculated from beta-peptides and polynucleotides according to the classical 'Dipole Interaction Model' of Applequist and the quantum mechanical 'matrix method'.As beta-peptides a hexa- and a hepta-peptide are examined. The calculations which are done at first …
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Quantitative Proteomics Analysis of Differentially Expressed Proteins in Aβ(17-42) Treated Synaptosomes
… have an extensive deposition of Aβ(17-42) peptide, which could contribute to their increased rate of developing Alzheimer's disease (AD). Since AD cannot be properly diagnosed until autopsy, development of a novel Down syndrome model using Aβ(17-42) could be beneficial in determining …
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