Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Beta-Lactam Resistance"”.
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Structural characterization of superbug proteins involved in regulating beta-lactam resistance
The widespread use of β-lactams has undermined their effectiveness as chemotherapeutic agents by fueling the evolution and dissemination of multiple resistance mechanisms, including: (1) production of hydrolytic β-lactamase enzymes that inactivate β-lactams, (2) expression of PBPs with …
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Multivariate Methods for the Study of Beta-lactam Resistance in Streptococci
… efforts to conduct large-scale surveillance of resistance in circulating bacterial populations. While these datasets have provided a rich source of information to study drug resistance, they have also highlighted its complex, multivariate nature, involving correlations both within and between …
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The determination and characterisation of beta lactam resistance in clinical isolates of Acinetobacter baumannII
Bibliography leaves 122-136.
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Mechanisms of Regulation and Resistance for Plasmid-Encoded ampC Beta-Lactamase Genes
BETA-lactam antibiotics are the largest class of antimicrobial drugs and the most frequently prescribed world wide. As the use of these agents increased so did the evolution of bacterial BETA-lactam resistance. BETA-lactamases are collectively the most commonly identified BETA-lactam resistance …
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Antibiotic Resistance Genes in Marquette County Michigan's Wastewater
… resistant bacteria survive and pass antibiotic resistance genes (ARGs) to their progeny cells. Few ARG studies have utilized wastewater influent samples as a method of surveillance in rural communities in the United States. This study investigated ARGs in Michigan’s Upper Peninsula. Two samples …
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Molecular methods for the detection of TEM- and SHV-related beta lactamase genes in members of the Enterobacteriaceae
Bacterial resistance to antibiotics is a common and important clinical problem. Beta lactam resistance in Gram negative bacilli is mediated predominantly by beta lactamases, enzymes able to hydrolyse the beta lactam ring. The commonest plasmid mediated beta lactamases in the Enterobacteriaceae are …
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Molecular Mechanisms of Antimicrobial Resistance In Multi-Drug Resistant Enterococci
<p>Antibiotic resistance is a major global public health threat. Enterococci are recalcitrant, nosocomial pathogens that can be intrinsically resistant to valuable antibiotics, like beta-lactams, or evolve resistance to all existing antimicrobials. The LiaFSR system regulates resistance to cell …
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Overexpression, purification and ligand interaction studies of intact membrane sensory kinases from enterococci: towards agonist and antagonist screening
… particularly important in controlling antibiotic resistances in enterococci. Enterococci are amongst the most significant agents of nosocomial infections in the UK. The present study involved an investigation of two membrane sensor kinases known to be involved in antibiotic resistance in …
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Beyond MICS: Determining the Role of Porin Production and β-Lactamase Expression in Resistance and Cellular Physiology of Klebsiella pneumoniae
Background: K. pneumoniae is capable of resistance to β-lactam antibiotics through expression of β-lactamases and downregulation of outer membrane porins. However, the extent to which these mechanisms interplay in a resistant phenotype is not well understood. β-lactamase expression has long been …
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Nasopharyngeal colonization dynamics with Streptococcus pneumoniae and associated antimicrobial resistance in a South African birth cohort
… study longitudinally investigated antimicrobial resistance amongst pneumococci colonizing the nasopharynx of South African infants immunized with the 13- valent pneumococcal conjugate vaccine (PCV13). Furthermore, the study explored strainlevel pneumococcal colonization patterns and associated …
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A computational approach to understanding maternal influences on the development of ruminant neonates
… induced a transient reduction in both alpha and beta microbial diversity and decreased the relative abundance of specific bacterial taxa, including Salmonella and Clostridiales, during the nursing period. Although the microbial community exhibited resilience and largely recovered by day 56, core …