Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Beta-Arrestin2"”.
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G-Protein gekoppelte Rezeptoren für Parathormon : molekulare Determinanten der intrazellulären Signalwegankopplung
… Untersuchungen der Membrantranslokation von beta Arrestin2 mit einer anschließenden Internalisierung des Rezeptors zeigten, dass sowohl der P2R als auch die hiervon abgeleiteten Hybridrezeptoren selektiv durch Stimulation mit TIP39, nicht jedoch nach einer Stimulation mit PTH, eine …
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Targeting troubled translation : investigating novel therapeutic targets in mouse models of fragile X and 16p1 1.2 deletion syndrome
… we show that manipulation of two novel targets, [beta]-arrestin2 and glycogen synthase kinase 3[alpha] (GSK3[alpha]) are able to independently modulate translation downstream of mGlu₅ Avoiding dose-limiting consequences and unwanted side effects of globally targeting mGlu₅ signaling, …
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Targeting Opioid Receptor Signal Transduction to Produce Sustained Analgesia
… MOPs, delta opioid receptors (DOPs) and β-arrestin2 (BAR2) are all necessary components of the signalling complex in nociceptive neurones for morphine analgesic tolerance; c-Src (a tyrosine kinase), thought to couple to MOP receptors through BAR2 has<br/>also been implicated.<br/><br/>To …
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Phosphorylation Bar Codes Induce Distinct Conformations and Functionalities of beta-Arrestin
… G-protein into independent Galpha and Gbeta;gamma signaling subunits. Following their activation, 7TMRs are phosphorylated by G-protein coupled receptor kinases (GRKs) and subsequently recruit beta-arrestins. beta-arrestins are multifunctional adaptor proteins which not only desensitize …