Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Beta cell dysfunction"”.
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The non-canonical NF-kappaB pathway as a novel player in beta cell dysfunction in diabetes
Loss of pancreatic β cell mass and function is a feature of both type-1 and type-2 diabetes. The non-canonical NF-κB pathway has recently garnered attention at being involved in the development of peripheral insulin resistance (liver, muscle) in diabetes. Whether pancreatic β cell non-canonical …
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Islet Dysfunction In Diabetes
… resulting from gradual failure of pancreatic beta cells to synthesize and secrete sufficient insulin to meet the metabolic demands and the inability of tissues [muscle, adipose and liver] to efficiently utilize the secreted insulin leading to an overall increase in blood glucose levels …
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Hemoglobin A1C and the Diagnosis of Diabetes and Prediabetes in Children and Adolescents
… addition to comparing the relationship of A1C to beta cell dysfunction and insulin sensitivity. A retrospective review of 902 patient electronic medical records in an urban endocrinology clinic was conducted. Based on FPG and 2-hr glucose during the OGTT, patients were classified based on the ADA …
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Insulin based analogs HLVEALYLV and LVEALYLV to inhibit the formation of amyloid fibrils in beta cells
… in the islets of Langerhans of pancreatic beta cells. Aggregation of hIAPP fibrils is believed to be toxic to beta cells and responsible for beta cell dysfunction and death associated with type 2 diabetes. Insulin has been found to act against the actions of hIAPP. The internal sequence of …
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Epigallocatechin Gallate in the Regulation of Insulin Secretion
… (T1D) and Type 2 diabetes (T2D), inadequate beta-cell mass and beta-cell dysfunction lead to impaired insulin secretion, and ultimately worsen glycemic control. Green tea has drawn wide attention due to its possible health-promoting properties, including enhancement of beta-cell function. We …
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Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
Type 2 diabetes is hallmarked by insufficient beta-cell insulin secretion and inappropriate alpha-cell glucagon secretion concomitant to peripheral insulin resistance. However, the mechanisms underlying dysregulation of pancreatic beta- and alpha-cells in type 2 diabetes require further …
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The Effects of Chronic Stress and Exercise on Mouse Pancreatic Islet of Langerhans Morphology and Muscle Atrophy Gene Expression
… insulin sensitivity and the insulin producing beta cells of the pancreas. Exercise could serve as a possible countermeasure to the damaging effects of chronic stress due to its proven ability to increase insulin sensitivity at the level of the muscle and improve or maintain beta cell function …
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Lipid metabolism in the pancreatic beta-cell. Implications for insulin secretion.
… the role of lipid metabolism with regard to beta-cell function and insulin secretion. Lipids are known to play a crucial functional role in the pancreatic beta-cell, where they are essential for adequate hormone release, but may also exert a long-term toxic effect, leading to beta-cell …
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The use of human pluripotent stem cells to model HNF1B-associated diabetes
… in multisystem disease including diabetes due to beta-cell dysfunction and pancreatic hypoplasia. However, the mechanisms that underlie development of diabetes in HNF1B mutation carriers are still not fully understood due to lack of an appropriate model system. Human induced pluripotent stem cells …
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
Prolonged exposure of pancreatic beta cells to excessive levels of glucose and fatty acids is postulated to contribute to beta cell dysfunction and beta cell death in type 2 diabetes. Nicotinamide, via its major metabolite NAD+, is involved in a wide range of biological processes, including the …
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The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function
… understood. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting that Rap1 may promote several processes associated with metastasis. Recent studies in another biological system have demonstrated that the Rap activator proteins, Epac, are important regulators of …
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Spinophilin Signaling: Impacts on Body Weight, Obesity, and Beta-Cell Function
… Diabetes (T2D). Obesity-induced T2D is caused by dysfunction of the insulin-producing beta cells of the pancreas. However, mechanisms that promote obesity and the mechanisms by which obesity leads to beta cell dysfunction are not fully known. Spinophilin is a filamentous (F)-actin binding, protein …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… and free fatty acids (FFAs) induces pancreatic beta cell dysfunction and death, which may contribute to the development of type 2 diabetes. A deficiency of insulin through loss of beta cell mass, and subsequent impaired compensation against insulin resistance is believed to be a pathogenic cause …
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Role of Transient Receptor Potential (TRP) Channels in Nociception
… function of TRPV4 and TRPV1 in the DRG neuronal cell bodies as well as their central terminals and determined the modulation by protein kinase C (PKC). Both TRPV4 and TRPV1 are expressed in DRG and laminae I and II of the spinal dorsal horn (DH). Ca<super>2+</super> fluorescence imaging and …
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A multi-ancestry genetic analysis of type 2 diabetes
… cases, is characterised by pancreatic islet beta cell dysfunction and reduced insulin response in insulin-sensitive tissues, and is associated with a myriad of risk factors, including diet, obesity, activity measures, and genetics. Over the past century, there have been extensive research …
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Manganese-enhanced magnetic resonance imaging in cardiometabolic disorders
… diseases. Dysregulated myocardial and pancreatic beta-cell calcium handling may be a key mediator and driver of these disorders. Manganese is a calcium analogue which has paramagnetic properties. Cellular uptake of manganese by voltage gated L-type calcium channels causes T1 shortening and …