Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Beta adrenergic receptor"”.
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Sex differences in the cardiac beta-adrenergic receptor contractile response
… difference is not present following menopause. &beta-adrenergic receptors are pharmaceutical targets in the treatment of cardiovascular disease, and sex differences in &beta-adrenergic responsiveness have been demonstrated. However, limited studies have addressed the mechanism(s) underlying these …
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Compound 49b: A Novel Beta-Adrenergic Receptor Agonist in the Treatment of Diabetic Retinopathy
… We have previously shown that a non-specific beta-adrenergic receptor agonist, isoproterenol, was effective in preventing functional and morphological changes associated with diabetic retinopathy in the rat. Isoproterenol also produced left ventricle remodeling suggesting it entered the …
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Myocardial Contractility in Fetal Sheep Exposed to Long-term Hypoxia at High Altitude : Activator Calcium and Beta-adrenergic Receptor Function
… dihydropyridine (DHPR), ryanodine (RyR), and β-adrenergic receptor densities, and measured basal and stimulated intracellular cAMP levels. In hypoxic fetuses, left ventricular wet weight was unchanged, but right ventricular weight was ~20% lower than controls. Curves describing the …
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In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma
… ligand binding and functional activity of the beta-2 adrenergic receptor. These studies were prompted by previous reports that the postulated beta-2 adrenergic receptor abnormality in allergic asthma could be induced, induced by autoantibodies. I established and optimised beta-2 adrenergic …
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Effects of Pasteurella haemolytica on Pulmonary Vascular Adrenergic Mechanisms
… by disruption of the pulmonary vascular adrenergic system. However, only a limited amount of research has addressed the adrenergic system and its relationship to the etiology and pathophysiology of this disease. In an attempt to further investigate the contributions of the vascular …
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A Study of the Action of Prostaglandin F2a on the Guinea-Pig Isolated Trachea
… was placed on considerations of the possible beta-adrenergic blocking activities of this essential fatty-acid derivative. | Experiments were performed using a 20 ml tissue bath and a modified phosphate-Tyrode solution. Measurements were made by an isotonic myograph and displayed on a …
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CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation
… the effect of acute psychological stress and \(\beta\)-adrenergic receptor (\(\beta\)AR) stimulation on the mobilization of CD8+ T lymphocytes (CD8TLs) and progenitor cell (PC) populations. Chapter 2 demonstrated that CD8TL stress- and \(\beta\)AR- sensitivity increases in parallel with greater …
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Sympathetic Innervation of the Rat Adrenal Cortex and Its Effects on the Compensatory Adrenal Cortical Growth Response to Unilateral Adrenalectomy (Catecholamine, Endocrine, Splanchnic Nerve, Cell Proliferation)
… growth was observed in animals treated with the (beta)-blockers propranolol (10 or 25 mg/kg) and Sotalol (25 or 50 mg/kg), although vehicle-injected animals failed to show the response. These results suggested that (beta)-adrenergic receptor blockade released a stress-related inhibition of the …
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AB affects apoE transcriptionally through the activation of B-AR, cAMP and AP-2
… of Alzheimer’s disease (AD) are amyloid beta protein (Aβ) and apolipoprotein E (apoE). We and others have reported that Aβ elevates apoE protein levels in astrocytes, which in turn could alter lipid trafficking and cell function. The mechanism for the Aβ-induced increase in apoE levels is …
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Forebrain Noradrenergic Alterations and Anxiety After Myocardial Infarction
… to test the hypothesis that alterations in noradrenergic transmission in the forebrain contribute to the development of anxiety disorders and arrhythmia susceptibility after MI. Using a rat coronary artery ligation model of MI, we first assessed MI-induced changes in cytochrome oxidase …
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Altered Autonomic Nervous System Function in Chickens Divergently Selected for Body Weight
… following injection of atropine, a muscarinic receptor blocker, and LWS birds had a greater decrease in BP and HR to propranolol, a beta- adrenergic receptor blocker than the HWS birds. These results suggested that HWS chickens have higher parasympathetic tone, whereas LWS chickens have a …
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Effects of ractopamine hydrochloride on nutrient digestibility, environmental N excretion, regulation of skeletal muscle growth, and beta-receptor subtypes in finishing beef steers
Beta-adrenergic agonists such as ractopamine hydrochloride (Actogain, Zoetis, Parsippany, NJ) are growth-promoting technologies that when fed at the end of the finishing period in cattle act as repartitioning agents, redirecting energy toward protein accretion and away from lipid deposition. …
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Effects of Neuropeptide Y on Adipocyte Metabolism
… We found that NPY potentiated isoproterenol (P-adrenergic agonist) stimulated lipolysis. This potentiation occurred upstream of adenylyl cyclase, since NPY did not enhance forskolin (direct activator of adenylyl cyclase) stimulated lipolysis. The potentiation was mediated by increased …
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PREDICTION OF HUMAN SYSTEMIC, BIOLOGICALLY RELEVANT PHARMACOKINETIC (PK) PROPERTIES BASED ON QUANTITATIVE STRUCTURE PHARMACOKINETIC RELATIONSHIPS (QSPKR) AND INTERSPECIES PHARMACOKINETIC ALLOMETRIC SCALING (PK-AS)
… classes of drugs, namely opioids, β-adrenergic receptor ligands (β-ARL) and β-lactam antibiotics (β-LAs) using pertinent human and animal systemic PK properties (fu,, CLtot, Vdss, fe) and their biologically relevant unbound counterparts from the published literature, followed by an …
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Effect of Nedd4 Haploinsufficiency on Insulin Sensitivity, Adiposity and Neuronal Behaviors
… induced lipolysis through stimulation of β-adrenergic signaling as evidenced by enhanced β2 adrenergic receptor (β2-AR) cell surface levels; 2) repressed expression of a key adipogenic regulator, peroxisome proliferator-activated receptor gamma (PPARγ) in Nedd4- haploinsufficient mice in the …