Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Beta Lactamase"”.
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In vitro-Untersuchungen zum Sekretionsmechanismus der beta-Lactamase in Escherichia coli
… es Ausnahmen. In dieser Arbeit wurde mit der beta-Lactamase ein sekretorisches Protein untersucht, das nicht auf SecB als exportspezifisches Chaperon angewiesen ist und somit keinem dieser Transportwege eindeutig zugewiesen werden kann. Zu Beginn dieser Arbeit war der Transportmechanismus der …
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Transposon Tn5 mutagenesis in Pseudomonas aeruginosa: a study of Beta-lactamase expression
… the chromosomally-encoded, inducible class C B-lactamase gene of P. aeruginosa. Transposon mutagenesis was considered an effective method for the identification and subsequent cloning of such regulatory genes. To facilitate identification of Tn5 insertions in P. aeruginosa a transposon …
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Mechanisms of Regulation and Resistance for Plasmid-Encoded ampC Beta-Lactamase Genes
BETA-lactam antibiotics are the largest class of antimicrobial drugs and the most frequently prescribed world wide. As the use of these agents increased so did the evolution of bacterial BETA-lactam resistance. BETA-lactamases are collectively the most commonly identified BETA-lactam resistance …
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Antimicrobial Resistance Mediated By Synthesis of Richmond and Sykes Type I Beta-Lactamase
A number of beta-lactam antibiotics that are relatively resistant to hydrolysis by beta-lactamases have been developed. These new compounds have expanded antibacterial activity but also have posed several challenging clinical problems including therapeutic failures and relapses of infections. …
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Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae: Epidemiology, Risk Factors, and Duration of Carriage
In human medicine, the most important family of bacteria is Enterobacteriaceae, which includes genera and species that cause well-defined diseases and also nosocomial infections. These bacteria can give rise to numerous infections such as septicaemia and urinary tract infections. It is important to …
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Discovery and optimization of inhibitors and probes that target New Delhi metallo-[beta]-lactamase
… of β-lactam hydrolyzing enzymes, known as β-lactamases, threatens their clinical efficacy. β-lactamases typically have a conserved serine in their active site that serves as a nucleophile in hydrolysis of the β-lactam substrate. Codrugs in the form of covalent inhibitors that target this …
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Studies on the mode of action and beta-lactamase inhibitory properties of novel oxapenem compounds
… oxapenem compounds were evaluated for their ß-lactamase inhibitory and antibacterial properties. Two (AM-112 and AM-113) displayed intrinsic antibacterial activity with MICs of between 2 to 16µg/ml and 0.5-2µg/ml against Escherichia coli and methicillin-sensitive and -resistant Staphylococcus …
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Genetic and molecular characterization of origins of replication from beta-lactamase-producing plasmids of Neisseria gonorrhoeae.
… and organization existing amongst the gonococcal beta-lactamase-producing plasmids. The second major aspect of this work deals with investigations into the genetic and molecular characterization of the multiple origins of replication of the gonococcal beta-lactamase-producing plasmids. The …
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Mechanisms Involved in the Expression of the AmpC Beta-lactamase Gene blaCMY-2 in Escherichia coli
… that express plasmid-encoded AmpC β-lactamases can be resistant to third generation cephalosporins and β-lactam/β-lactamase inhibitor combinations. Infections by these bacteria are associated with increased patient morbidity and mortality. Little is known about how plasmid-encoded …
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Molecular methods for the detection of TEM- and SHV-related beta lactamase genes in members of the Enterobacteriaceae
… is a common and important clinical problem. Beta lactam resistance in Gram negative bacilli is mediated predominantly by beta lactamases, enzymes able to hydrolyse the beta lactam ring. The commonest plasmid mediated beta lactamases in the Enterobacteriaceae are those related to either TEM-1 …
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Epidemiology of extended spectrum beta-lactamase and carbapenemase-producing bacteria in stool from apparently healthy children, South Africa
Background: The prevalence of extended-spectrum beta-lactamase (ESBL) - and carbapenemase-producing Enterobacteriaceae in healthy humans in the community is largely unknown. We aimed to determine the prevalence and genetic characteristics of ESBL- and carbapenemase-producing Enterobacteriaceae in …
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Occurrence of extended –spectrum beta-lactamase-producing enterobacteriaceae and bacterial loads in dust from poultry farms in Lusaka-Zambia.
… is detrimental when inhaled. Extended Spectrum beta lactamases are a universal public health alarm which are frequently identified in humans and animals including poultry. Poultry dust is a possible source of drug resistant microorganisms including Extended spectrum beta lactamases which confer …
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Occurrence of extended –spectrum beta-lactamase-producing enterobacteriaceae and bacterial loads in dust from poultry farms in Lusaka-Zambia.
… is detrimental when inhaled. Extended Spectrum beta lactamases are a universal public health alarm which are frequently identified in humans and animals including poultry. Poultry dust is a possible source of drug resistant microorganisms including Extended spectrum beta lactamases which confer …
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Colonisation with extended spectrum beta-lactamase producing and carbapenem-resistant enterobacterales in children admitted to a paediatric referral hospital in South Africa
… describing colonisation with extended spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and carbapenem-resistant Enterobacterales (CRE) among children in subSaharan Africa. Colonisation often precedes infection and multi-drug-resistant Enterobacterales are important causes of invasive …
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A study on the detection of extended spectrum beta lactamase producers and class I intergrons in e. coli isolates from urinary tract infected patients at UTH.
Escherichia coli that produce extended spectrum beta lactamase (ESBL) enzymes pose a global challenge in the management of urinary tract infections (UTIs) caused by these organisms. Beta lactamases are the primary cause of resistance to beta lactam antibiotics. These enzymes confer multi drug …
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Detection of extended spectrum beta lactamase producing enterobacterales from diseased chickens and estimation of antimicrobial usage from antibiotics importation and sales data in Lusaka district, Zambia.
… the different types of extended-spectrum -lactamase (ESBL) producing Gram negative bacteria (GNB) causing diseases in chickens in Lusaka and to asses possible association between antibiotic resistance and antibiotic consumption. A cross-sectional study was conducted in Lusaka, which …
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A study on the detection of extended spectrum beta lactamase producers and class I intergrons in e. coli isolates from urinary tract infected patients at UTH.
Escherichia coli that produce extended spectrum beta lactamase (ESBL) enzymes pose a global challenge in the management of urinary tract infections (UTIs) caused by these organisms. Beta lactamases are the primary cause of resistance to beta lactam antibiotics. These enzymes confer multi drug …
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Detection of extended spectrum beta lactamase producing enterobacterales from diseased chickens and estimation of antimicrobial usage from antibiotics importation and sales data in Lusaka district, Zambia.
… the different types of extended-spectrum -lactamase (ESBL) producing Gram negative bacteria (GNB) causing diseases in chickens in Lusaka and to asses possible association between antibiotic resistance and antibiotic consumption. A cross-sectional study was conducted in Lusaka, which …
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Interactions between Streptococcus pneumoniae and Moraxella catarrhalis in polymicrobial communities affect antimicrobial resistance and survival in vivo
… Prior studies in the lab have shown that beta-lactamase production and quorum sensing play important roles in polymicrobial biofilms with S. pneumoniae and H. influenzae, and M. catarrhalis and H. influenzae, respectively. In these studies, the importance of both beta-lactamase and …
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Mechanisms of resistance to β-lactam antibiotics in Streptomycetes
… of penicillin G is not directly related to β-lactamase production in the panel of isolates examined. There was no correlation between the MICs of penicillin G and the growth rate in these isolates. Likewise, there was no association between the position of beta-lactamase producing and …
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