Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Benzyl Aspartate"”.
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
… family of EAAT3 preferring inhibitors, L-β-benzyl aspartate (L-β-BA) and L-β-BA derivatives. L-β-BA and derivatives were initially synthesized in an approximate 2:1 ratio of diasteromers (threo:erythro), using base promoted enolate addition. Kinetic analysis of 3H-D-aspartate …
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
… family of EAAT3 preferring inhibitors, L-β-benzyl aspartate (L-β-BA) and L-β-BA derivatives. L-β-BA and derivatives were initially synthesized in an approximate 2:1 ratio of diasteromers (threo:erythro), using base promoted enolate addition. Kinetic analysis of 3H-D-aspartate …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… glycine (L-CCG-IV) and L-B-threo-benzyloxy-aspartate (L-B-TBOA). This model predicts distinct regions that might influence the potency and selectivity of EAAT2 ligands, including: 1) a highly conserved positioning of the two carboxylate and the amino groups, 2) a nearby region that …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… glycine (L-CCG-IV) and L-B-threo-benzyloxy-aspartate (L-B-TBOA). This model predicts distinct regions that might influence the potency and selectivity of EAAT2 ligands, including: 1) a highly conserved positioning of the two carboxylate and the amino groups, 2) a nearby region that …