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Showing 1 to 10 of 10 for “"Benzopyran"”.
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Studies in Benzopyran chemistry
6-Bromo-, 7-bromo-, 8-bromo- and 6,8-dibromo- 2,2-dimethylchromenes have been synthesised. The 6-bromoand 8-bromo-derivatives were prepared by Claisen rearrangement of aryl propargyl ethers, derived from phenols and 3-chloro-3-methylbut-1-yne. 7-Bromo- and 6,8-dibromo-2,2-dimethylchromenes were …
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Studies in Furobenzopyran Chemistry
… Whilst C-2 lithiation of 2-(4-oxo-4H[1]benzopyran-3-yl)-1,3-dioxane with n-BuLi does occur, the reaction is complex and leads, ultimately, to a benzofuranone derivative. The structure and relative stereochemistry of this compound, which possesses two 1,4-disposed stereogenic centres, was …
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Chemiluminescence From the Thermal Decomposition of 1,4-Diphenyl-1,4-Dioxa-2-Benzopyran-3-One. Direct and Indirect Luminescence Involving an Ortho-Xylylene Peroxide
1,4-Dipheny1-1,4-dioxa-2-benzopyran-3-one (37), an endoperoxide similar in structure to the endoperoxide proposed as an intermediate in the chemiluminescent reaction of luminol, is prepared by the addition of singlet oxygen to 1,4-diphenyl-2-benzopyran-3-one. This endoperoxide yields …
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Design and synthesis of novel biologically active flavones and isoflavones
… by immediate esterification to furnish the benzopyran core with a boronic ester at 3-position. Subsequent Suzuki-Miyaura coupling reaction allowed for the attachment of various aromatic systems, giving access to 4-arylisoflavenes which were readily converted to cis 4-arylisoflavans by …
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Biomolecular effects and bioclinical applications of PARPs inhibitors
… PD98059 (2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one) on PARP-1 expression in unstimulated and in CM-stimulated GP8.3 cells was analyzed by RT-PCR. PARP-1 expression and phospho-ERK activation were significantly reduced by treatment of GP8.3 cells with PJ-34 or PD98059. By LSM, we …
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Metal catalyzed generation of reactive benzomethane intermediates for the synthesis of benzopyrans, tetrahydroquinolines and chiral aryl methanes
Benzopyrans and tetrahydroquinolines are motifs commonly found in natural products and pharmaceuticals. Each of these privileged scaffolds have a common benzomethane moiety. Iron (III) salts generate benzomethane intermediates from o-hydroxybenzyl alcohols or o-aminobenzyl alcohols under mild …
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Method Development Towards Catalytic Transformations of Reactive Intermediates
… was accomplished when synthesis of chromans and benzopyran derivatives were found. Later efforts focused on an aldol approach towards o-QMs, which are rarely employed.Chapter three examined a Lewis acid catalyzed synthesis of unsymmetrical ethers from direct functionalization of benzyl alcohols. …
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AB INITIO and DFT computational study of Myristinin A and A structurally- related molecule
… ihydroxy-3-(9tetradecenoyl)phenyl]-3,4-dihydro-2H-benzopyran-7-ol, here denoted as DBPO). The two compounds pertain to the class of acylphloroglucinols. They were firstly isolated from Horsfieldia amygdaline, and they exhibit a variety of biological activities, including potent anti-inflammatory …
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Contributions to benzothiopyran chemistry
… 6H, 1 2H-[ 1 ]Benzothiopyrano[3,4-b][ 1]benzopyran- 12-ones have been synthesised by 2-fluorobenzoylation of 3-pyrrolidino-2H-[ 1]benzothiopyTan and intramolecular cyclisation of the resulting diketones. Selective reduction of the a43-unsaturated carbonyl function has been achieved, …