Global ETD Search
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Showing 1 to 18 of 18 for “"Benzofuran"”.
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The Chemiluminescence of Benzofuran-2(3H)-Ones
… and the chemiluminescent reactions of certainbenzofuran-2(3~)-ones. The main aims were to find practicableroutes for the preparation of benzofuran-2(3H)-ones, to definethe conditions required for chemiluminescence, to elucidate thenature of the products from the chemiluminescent reactions, …
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Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands
… thc) provided a molecular framework from which a benzofuran scaffold was hypothesized to provide opportunities to include most of the pharmacophoric elements of 10a-oh thc. Target molecules were designed to maximally explore the chemical space of this new scaffold to elucidate a structure activity …
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Synthesis, characterization and activity evaluation of phosphate-modified hydroprocessing catalysts for benzofuran hydrodeoxygenation
Includes bibliographical references (pages 171-177).
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Studies in the synthesis and impurity profiling of pharmacologically active benzodifurans
Substituted 2,3-dihydrobenzofuran derivatives as well as their benzofuran and benzodifuranyl analogues are versatile heterocycles that are increasing in prominence as key building blocks in organic chemistry. In particular, benzodifuran-containing structures are gaining significant interest in …
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Designing Allosteric Inhibitors of Thrombin
… showed that sulfation at the 5-position of the benzofuran scaffold was essential for targeting thrombin. Michaelis-Menten kinetic studies indicated a non-competitive, allosteric mechanism of inhibition. Site-directed mutagenesis, competitive binding and molecular modeling studies led to the …
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The synthesis and benzannulation reactions of (trialkylsilyl)vinylketenes
… efficient access to ortho-benzoquinones and benzofuran, benzoxepine, and benzoxocine ring systems are described. Additionally, unsuccessful attempts to prepare TAS-vinylketenes by the rearrangement of siloxy alkynes and by cross-metathesis are discussed.
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A study of the thermal degradation of model compounds of amine-cured epoxide resins
… compounds may be used as a synthetic route to benzofuran has been investigated.
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Enhancing the Performance of Pt(II)-Based Oxygen Sensing Probes by Expanding the Scope of N,C-Chelate and Ancillary Ligands.
… have greater sensitivities compared to the benzofuran-pyridyl and pyridyl-indole chelates. By further altering the backbone with the attachment of dimesityl boron, an enhancement in the oxygen sensitivity was observed, establishing borylation as a sensible strategy to improve an OSPs …
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ALPHA4BETA2 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS: FROM SUBTYPE SELECTIVE TO STOICHIOMETRIC ISOPHORM SELECTIVE PARTIAL AGONISM.
… of the naked and hydroxy/methoxy decorated benzofuran-based compound in order to study the implications of the flexibility reduction, abolishment of cycle stereogenic and of the one of the two oxygen in comparison with previously tested benzodioxane derivatives. Subsequently, the most …
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Insektizide Rocaglamid-Derivate und Verwandte Verbindungen aus Aglaia-Arten (Meliaceae)
… befinden sich sechs bisher nicht beschriebene Benzofurane (Rocaglamide), zwei Benzopyrane (je ein Aglain und ein Aglaforbesin), zwei Benzoxepine (Forbagline) sowie ein Zimtsäure-Putrescin-Bisamid. Die Strukturaufklärung erfolgte vor allem durch NMR-Spektroskopie (darunter 2D-Experimente wie …
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Synthetic, Sulfated, Lignin-Based Anticoagulants
… Our search identified a sulfated benzofuran trimer (a mimic of β-5 type linkage found in lignins) as a potent inhibitor of factor XIa. Surprisingly, this inhibitor did not compete with heparin. A plausible binding site in the A3 domain of factor XIa was proposed by using molecular …
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Design, synthesis, and biological evaluation of sigma receptors (σRS) ligands as potential pharmacotherapy for cancer and drug addiction
… ligands, we have synthesized a novel series of benzofuran-based ligands, and more analogs of the highly selective sigma-1, CM304.
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Gas-Phase Formation of Environmentally Persistent Free Radicals from Thermal Degradation of Catechol, Hydroquinone, Phenols and Tobacco
… the formation of naphthalene, indenol, indene, benzofuran-2-methyl, indenone, fluorene, and acenaphthylene, thus giving additional evidence of the formation of both labile and potentially persistent free radicals.
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Synthesis and anticancer evaluation of novel, functionalised bisindolylmaleimides and indolocarbazoles
… panel of compounds. Initially, 5,6-substituted benzofuran components were incorporated into the BIM and ICZ frame to generate a panel of 55 novel benzofuranylindolylmaleimides (BfIMs) and benzofuranopyrrolocarbazoles (BPCs). Significant anticancer activity was reported for the BfIM series in the …
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Chemical Studies of some Fungi
… It has been found that the yields of benzobisbenzofuranquinonoid (1) derivatives are greater when after initial nucleophilic attack on the ketoenoid system by the oxygen atom of the phenoxide ion, the carbon atom ortho to the vinyl-aryl ether linkage is activated towards further nucleophilic …
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Radical cyclization approach to a chemoenzymatic synthesis of morphine
… stereochemistry was proven by conversion to the benzofuran derivative [figure 7] which was found identical to that obtained from [figure 2]. See: Figure 9 ⟶ Figure 10 ⟶ Figure 11a, 11b The new diol [figure 9] was transformed to the protected derivative [figure 10]. The radical cyclization of …
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Investigations of benzothienopyrans and related compounds
… 9-(9Hfluorene), 1 '-indane, 3'-(2,3-dihydrobenzofuran), and 3'-(2,3-dihydrobenzo-[b]thiophene) units has been accomplished and their oxidative ring expansion by organoiodine(Ill) reagents e.g. PhI(OH)OTs has been investigated. The indane derivative afforded 1 2H-benzo[a]xanthen- 12-one and …